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HTLV-I infection and immune disorders : A role of HTLV-I tax gene for mesenchymal cell transformation.

Research Project

Project/Area Number 02454225
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionRheumatology Division, Institute of Medical Science, St Marianna University (1991-1992)
Tokyo Women's Medical University (1990)

Principal Investigator

NISHIOKA Kusuki  St. Marianna Univ.:Professor of Medicine, 医学部, 教授 (60049070)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Kazuhiko  Univ. of Tokyo :MD, 医学部, 講師 (80191394)
北島 勲  東京女子医科大学, 医学部, 助手 (50214797)
佐藤 和人  東京女子医科大学, 医学部, 講師 (40187175)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1992: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1991: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1990: ¥3,600,000 (Direct Cost: ¥3,600,000)
KeywordsHTLV-I associated arthropathy / synovial hyperplasia / proto oncogene / colony formation / genomic transfer / loss of contact inhibition / retrovirus / rheumatoid arthritis / 滑膜病変 / ATL / HTLVーI / HAAP / polymerase chain reaction / P40X / tax遺伝子 / HTLVーI遺伝子導入マウス
Research Abstract

The etiological factor(s) of rheumatoid arthritis (RA) have been well unknown.
The salient features is invasive synovial proliferation lead to bone erosion.
We have revealed the relationship of the HTLV-I infection to chronic arthropathy through out the study of clinical and molecular biological analysis and established the following results.
1) The patient with arthropathy in HTLV-I infection was proposed as one of the subsets of RA.
2) The presence and the expression of proviral HTLV-I genome in synovial cell derived from HAAP patient were clarified.
3) HTLV-I tax expression causes synovial transformation and hyperplasia in either human synovial or transgenic mice. Therefore, we demonstrate that HTLV-I tax gene is the first exogeneous retroviral gene which causes resembling rheumatoid arthritis.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] N.MIYASAKA,M.HIGAKI,K.SATO,J.HASHIMOTO,A.TANIGUCHI,H.KOHSAKA,K.TAMAMOTO,K.SHICHIKAWA,K.NISHIOKA: "Production of Interleukin-1 β-like Factor with Synovial Cell Growth Promoting Activity from Adult T-cell Leukemia Cells" Journal Autoimmunity. 4. 223-236 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.SATO,I.MARUYAMA,Y.MARUYAMA,I.KITAJIMA,Y.NAKAJIMA,Y.NAKAJIMA,M.HIGAKI,M.OSAME,K.NISHIOKA: "Arthritis in Patients Infected with Human T Lymphotropic Virus Type-1.Clinical and Immunopathologic Features." Arthritis & Rheumatism. 34(6). 715-721 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.IWAKURA,M.TOSU,E.YOSHIDA,M.TANIGUCHI,K.SATO,I.KITAJIMA,K.NISHIOKA,K.YAMAMOTO,T.TAKEDA,M.HATANAKA,H.YAMAMOTO,T.SEKIGUCHI: "Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-I" Science. 253. 1026-1029 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.KITAJIMA,K.YAMAMOTO,K.SATO,Y.NAKAJIMA,T.NAKAJIMA,I.MARUYAMA,M.OSAME,K.NISHIOKA: "Detection of Human T Cell Lymphotropic Virus Type-1 Proviral DNA and Its Gene Expression in Synovial Cells in Chronic Inflammatory Arthropathy" The Journal of Clinical Investigation. 88(4). 1315-1322 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.YAMAMOTO,H.SAKODA,T.KATO,M.OKUBO,M.DOHI,Y.MIZUSHIMA,K.ITO,K.NISHIOKA: "Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arhtritis revealed by a novel clonality analysis." International Immunology. 4(11). 1219-1223 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.NAKAJIMA,H.AONO,T.HASUNUMA,K.TAMAMOTO,I.MARUYAMA,T.NOSAKA,M.HATANAKA,K.NISHIOKA: "Overgrowth of Human Synovial Cells Driven by HTLV-I tax gene." Journal of Clinical Investigation. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] N.MIYASAKA, M.HIGAKI, K.SATO, J.HASHIMOTO, A.TANIGUCHI, H.KOHSAKA, K.TAMAMOTO, K.SHICHIKAWA, K.NISHIOKA: "Production of Interleukin-1 beta-like Factor with Synovial Cell Growth Promoting Activity from Adult T-cell Leukemia Cells" The Journal of Autoimmunity. 4. 223-236 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.SATO, I.MARUYAMA, Y.MARUYAMA, I.KITAJIMA, Y.NAKAJIMA, M.HIGAKI, K.YAMAMOTO, N.MIYASAKA, M.OSAME, K.NISHIOKA: "Arthritis in Patients Infected with Human T Lymphotropic Virus Type-1.Clinical and Immunopathologic Features." Arthritis & Rheumatism. 34(6). 715-721 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.IWAKURA, M.TOSU, E.YOSHIDA, M.TANIGUCHI, K.SATO, I.KITAJIMA, K.NISHIOKA, K.YAMAMOTO, T.TAKEDA, M.HATANAKA, H.YAMAMOTO, T.SEKIGUCHI: "Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-I" Science. 253. 1026-1029 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.KITAJIMA, K.YAMAMOTO, K.SATO, Y.NAKAJIMA, T.NAKAJIMA, I.MARUYAMA, M.OSAME, K.NISHIOKA: "Detection of Human T Cell Lymphotropic Virus Type-1 Proviral DNA and Its Gene Expression in Synovial Cells in Chronic Inflammatory Arthropathy" The Journal of Clinical Investigation. 88(4). 1315-1322 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.YAMAMOTO, H.SAKODA, T.NAKAJIMA, T.KATO, M.OKUBO, M.DOHI, Y.MIZUSHIMA, K.ITO, K.NISHIOKA: "Accumulation of multiple T cell clonotypes in thr synovial lesions of patients with rheumatoid arthtritis revealed by a novel clonality analysis." International Immunology. 4(11). 1219-1223 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.NAKAJIMA, H.AONO, T.HASUNUMA, K.TAMAMOTO, I.MARUYAMA, T.NOSAKA, M.HATANAKA, K.NISHIOKA: "Overgrowth of Human Synovial Cells Driven by HTLV-I tax gene." The Journal of Clinical Investigation. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] N.MIYASAKA,M.HIGAKI,K.SATO,J,HASHIMOTO,A.TANIGUCHI,H,KOHSAKA,K.TAMAMOTO,K.SHICHIKAWA,K.NISHIOKA: "Production of Interleukin-1 β-like Factor with Synovial Cell Growth Promoting Activity from Adult T-cell Leukemia Cells" Journal of Autoimmunity. 4. 223-236 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.SATO,I.MARUYAMA,Y.MARUYAMA,I.KITAJIMA,Y.NAKAJIMA,M.HIGAKI,K.YAMAMOTO,N.MIYASAKA,M.OSAME,K.NISHIOKA: "Arthritis in Patients Infected with Human T Lymphotropic Virus Type-1.Clinical and Immunopathologic Features." Arthritis & Rheumatism. 34(6). 715-721 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.IWAKURA,M.TOSU,E.YOSHIDA,M.TANIGUCHI,K.SATO,I.KITAJIMA,K.NISHIOKA,K.YAMAMOTO,T.TAKEDA,M.HATANAKA,H.TAMAMOTO,T.SEKIGUCHI: "Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-I" Science. 253. 1026-1029 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] I.KITAJIMA,K.YAMAMOTO,K.SATO,Y.NAKAJIMA,T.NAKAJIMA,I.MARUYAMA,M.OSAME,K.NISHIOKA: "Detection of Human T Cell Lymphotropic Virus Type-1 Proviral DNA and Its Gene Expression in Synovial Cells in Chronic Inflammatory Arthropathy" The Journal of Clinical Investigation. 88(4). 1315-1322 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.YAMAMOTO,H.SAKODA,T.NAKAJIMA,T.KATO,M.OKUBO,M.DOHI,Y.MIZUSHIMA,K.ITO,K.NISHIOKA: "Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arhtritis revealed by a novel clonality analysis." International Immunology. 4(11). 1219-1223 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.NAKAJIMA,H.AONO,T.HASUNUMA,K.TAMAMOTO,I.MARUYAMA,T.NOSAKA,M.HATANAKA,K.NISHIOKA: "Overgrowth of Human Synovial Cells Driven by HTLV-I tax gene." Journal of Clinical Investigation. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] MIYASAKA N.;NISHIOKA K.et al: "Production of Interleukin-1 β-like Factor with Synovid Cell Growth Promoting Activity from Adult T-cell Leukenia Cells" Journal of Autoimmunity. 4. 1223-236 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] SATO K.;NISHIOKA K.et al: "Arthritis in Patients Infeted with Human Lymphotropic Virus Typ-1" Arthritis & Rheumatism. 34-6. 715-721 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西岡 久壽樹: "ウイルス感染と関節炎ーC型レトロウイルスによる滑膜増殖機構ー" リウマチ. 31ー4. 420-429 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] IWAKURA Y.;NISHIOKA K.et al: "Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-1" Science. 1026-1029 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西岡 久壽樹: "ウイルス感染と関節炎ーc型レトロウイルスによる滑膜増殖機構ー" リウマチ. 589-591 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] KITAJIMA I.;NISHIOKA K.et al: "Detection of Human T Cell Lymphotropic Virus Type-1 Proriral DNA and Its Gene Expression in Synovial Cells in Chronic Inflammatory Arthropathy" The Journal of Clinical Investigation. 1315-1322 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 佐藤 和人,西岡 久寿樹他: "HTLVー1 Associated Arthropathy(HAAP)" 臨床免疫. 23ー2. 250-258 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西岡 久寿樹: "病因の進歩に基づく新しい治療方針の現状と開発" 日本臨床. 50ー3. 629-638 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西岡 久寿樹: "HTLVーI炎症性結合織疾患" Medical Immunology. 18. 157-163 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 北島 勲,佐藤 和人,山本 一彦,西岡 久寿樹: "HTLVーI型関節炎" 感染炎症免疫. 19. 338-345 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐藤 和人,北島 勲,西岡 久寿樹他: "HTLVーI感染と滑膜炎" 炎症. 10. 133-136 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sato K,Kitajima I,Nishioka K,: "Arthritis in human Tーlymphotropic virus typeー1 (HTLVー1) carriers:Clinical and immunopathological features." Arthritis and Rheumatism. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kitajima I,Yamamoto K,Sato K,Nishioka K,: "Defection of HTLVー1 proviral DNA and the gene expression in synovial cells with chronic inflammatory arthropathy." J.Clin.Invest. (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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