| Project/Area Number |
02454249
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Okinaka Memorial Institute for Medical Research |
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Principal Investigator |
TAKAGI Akio Okinaka Memorial Institute for Medical Research, CHIEF Researcher, 主任研究員 (20010142)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Tomoji 財団法人冲中記念成人病研究所, 研究員
KOJIMA Susumu 財団法人冲中記念成人病研究所, 研究員 (10183336)
IDA Masayoshi 財団法人冲中記念成人病研究所, 研究員
紫芝 良昌 冲中記念成人病研究所, 主担研究員 (00072596)
荒木 誠 冲中記念成人病研究所, 研究員
黒岩 義之 冲中記念成人病研究所, 研究員 (40135249)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | mdx mouse / myoblast / implantation / dystrophin / 拒絶反応 / 筋移植 / 筋ジストロフィ- |
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| Research Abstract |
The experimental therapy was performed in the mdx dystrophic mouse by the application of myoblast transfer. Production of dystrophin was confirmed in the mdx muscle, suggesting the appearance of nuclear mosaicism in the host muscle fiber, However, dystrophin-positive fibers constituted less than 1% of injected muscle. This low incidence of positive fibers was attributed to the immunological rejection by the host muscle, methods to prevent the rejection were discussed.
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