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Myoblast transfer therapy in the hereditary myopathy

Research Project

Project/Area Number 02454249
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionOkinaka Memorial Institute for Medical Research

Principal Investigator

TAKAGI Akio  Okinaka Memorial Institute for Medical Research, CHIEF Researcher, 主任研究員 (20010142)

Co-Investigator(Kenkyū-buntansha) WATANABE Tomoji  財団法人冲中記念成人病研究所, 研究員
KOJIMA Susumu  財団法人冲中記念成人病研究所, 研究員 (10183336)
IDA Masayoshi  財団法人冲中記念成人病研究所, 研究員
紫芝 良昌  冲中記念成人病研究所, 主担研究員 (00072596)
荒木 誠  冲中記念成人病研究所, 研究員
黒岩 義之  冲中記念成人病研究所, 研究員 (40135249)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsmdx mouse / myoblast / implantation / dystrophin / 拒絶反応 / 筋移植 / 筋ジストロフィ-
Research Abstract

The experimental therapy was performed in the mdx dystrophic mouse by the application of myoblast transfer. Production of dystrophin was confirmed in the mdx muscle, suggesting the appearance of nuclear mosaicism in the host muscle fiber, However, dystrophin-positive fibers constituted less than 1% of injected muscle. This low incidence of positive fibers was attributed to the immunological rejection by the host muscle, methods to prevent the rejection were discussed.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Takagi,A: "Increased leakage of calcium ion from the sarcoplasmic reticubum of the mdx mouse" J.Neural Sci. 110. 160-164 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 高木 昭夫: "重症筋無力症" Medicina. 29. 2076-2079 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 高木 昭夫: "悪性高熱,悪性症候群におけるライアノジンレセプター異常" 麻酔と蘇生. 27S. 107-112 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takagi,A: "Muscle pathology in polymyalgia rbeumatica" Jap J.Med. 30. 516-523 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 高木 昭夫: "悪性症候群" 神経内科治療. 8. 597-600 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 高木 昭夫編著: 神経内科実践マニュアル,文光堂, 472 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takagi A: "Increased leakage of Ca ion from the SR of the mdx mouse" J. Neurol Sci. 110. 160-164 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kojima S: "Muscle pathology in polymyologic iheumatica" Jap J Mediune. 30. 516-523 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takagi,A: "Increased leakage of calcium ion from the sarcsplasmic reticulum of the mdx mouse." J Neural Sci. 110. 160-164 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 高木 昭夫: "重症筋無力症" Medicina. 29. 2076-2079 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 高木 昭夫: "悪性高熱,悪性症候群におけるライアノジンレセプター異常" 麻酔と蘇生. 27S. 107-112 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takagi A: "Muscle pathology in polymyalgia rheumatica" Jap J Med. 30. 516-523 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 高木 昭夫: "悪性症候群" 神経内科治療. 8. 597-600 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 高木 昭夫 編著: "神経内科実践マニュアル" 文光堂, 472 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takagi,A.: "Increased leakage of calcium ion from the sarcoplasmic reticubem of mdx mouse" J.Neurol,Sci. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kojima,S.: "Muscle pathology in polymyolgia rheumatica" Japanese J.Medicine. 30. 516-523 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 高木 昭夫: "悪性症候群" 神経内科治療. 8. 597-600 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小島 進: "悪性高熱,悪性症候群におけるライアノジンレセプタ-異常" 麻酔と蘇生. 27別冊. 107-112 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 井田 雅祥ほか: "mdxマウスに筋芽細胞移植による組織学的な効果について" 虎の門病院研究報告店(1990年度).

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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