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Clinical usefulness of Gd-DTPA in MRI and its effect upon lymphocyte chromosomes.

Research Project

Project/Area Number 02454283
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionTokyo Medical & Dental University (TMDU)

Principal Investigator

SUZUKI Soji  TMDU, Faculty of Medicine Professor Dept. of Radiology, 医学部, 教授 (80013829)

Co-Investigator(Kenkyū-buntansha) YAMAZAKI Etsuo  TMDU, Faculty of Medicine Professor Dept. of Radiology Assistant, 医学部, 助手 (20220303)
YAMADA Ichiro  TMDU, Faculty of Medicine Professor Dept. of Radiology Assistant, 医学部, 助手 (90182518)
MATSUBARA Sho  TMDU, Faculty of Medicine Professor Dept. of Radiology Assistant Professor, 医学部, 助教授 (40014120)
田寺 修一  東京医科歯科大学, 医学部, 助手 (70217008)
吉田 哲雄  東京医科歯科大学, 医学部, 助手 (30134696)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1991: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1990: ¥3,100,000 (Direct Cost: ¥3,100,000)
KeywordsMRI / Magnetic field / Gd-DTPA (the contrast medium in MRI / SCE / GdーDTPA / 染色分体交換に対する影響
Research Abstract

CLINICAL RESULT :
Signal intensities in various imaging techniques in MRI were calculated and the most adequate selection of TR and TE in each technique was postulated. Based upon the postulation, a combination of MR angiography(the maximum intensity projection, 3-D FT)and an administration of GD-DTPA was tried in cases of brain tumor with success.
EXPERIMENTAL RESULT :
The effects of a magnetic field, radiofrequency, and GD-DTPA on the sister chromatid, , exchange(SCE)in peripheral lymphocytes were investigated. Two ml of whole blood in tubes was exposed to magnetic force(1.5 T)and/or radiofrequency waves(63. -86 MHz, 0.4 W/kg of SAR). GD-DTPA was added at 1.25, 12.5 or 125 mol/ml per 2 ml of whole blood to some samples. Slides were made for SCE investigation, after the blodd was exposed to various conditions and cultured for 69 hours.
The frequency of SCEs were counted and evaluated using Student's t test. As the concentration of GD-DTPA rose, the frequency of SCE increased. Magnetic force and radiofrequency also induced some SCE aberrations. However, at the level of concentration of GD-DTPA in the clinical use, the contrast medium in MRI did not effect SCE frequency.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 鈴木 宗治: "MRI用常用磁性造影剤(特にGdーDTPA)について" Innervision. 5(10). 41-47 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 山田 一郎: "GdーDTPAを用いたMR血管撮影" Innervision. 6(7). 65-67 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 山田 一郎: "脳神経系の造影MRI" Innervision. 6(11). 27-32 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鈴木 宗治: "MRIー最新の進歩" 臨床成人病. 21. 359-360 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鈴木 宗治: "MRI用造影剤の基礎(1)(2)(3)(4)" 臨床放射線. 36. 1075-1076,1173-1174,1599-1600,1701-1702 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 山田 一郎: "Moyamoya Disease:Its Piagnosis by Threeーdimentional Timeーofーflight MRA ngiography" Radiolgy(U.S.A),accepted on Feb.5,1992.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Suzuki, Soji: "Paramagnetic contrast medium for MRI (Gd-DTPA)" Innervision. 5(10). (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yamada, Ichiro: "MR Angiography using Gd-DTPA" Innervision. 6(7). (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Suzuki, Soji: "Basic aspects of MRI contrast media : (1), (2), (3) & (4)" Clinical Radioloy. 36(9), 36(10), 36(11), 36(12). 1075-1076, 1173-1174, 1599-1600, 1701-1702 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yamada, Ichiro: "Moyamoya Disease : Its Diagnosis by Three-Dimentional Time-of-Flight MR Abgiography" Radiology (RSNA).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Yamazaki, Etsuo: "Effects of Gd-DTPA and exposure to various conditions upon lymphocyte chromosomes" Investigative Radiology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鈴木 宗治: "MRI用常用磁性造影剤(特にGdーDTPA)について" Innervision. 5(10). 41-47 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 山田 一郎: "GdーDTPAを用いたMR血管撮影" Innervision. 6(7). 65-67 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 山田 一郎: "脳神経系の造影MRI" Innervision. 6(11). 27-32 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 鈴木 宗治: "MRIー最新の進歩" 臨床成人病. 21. 359-360 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 鈴木 宗治: "MRI用造影剤の基礎(1)(2)(3)(4)" 臨床放射線(夏). 36. (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 山田 一郎: "Moyamoya Disease:Its Piagnosis by Threeーdimentional Timeーofーflight MRA ngiography" Radiolgy(U.S.A),accepted on Feb.5,1992.

    • Related Report
      1991 Annual Research Report
  • [Publications] 鈴木 宗治: "MRI用常磁性造影剤(特にGdーDTPA)について" Innervision. 5巻10号. 41-47 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山崎 悦夫: "染色分体交換に及ぼす磁場、RF波およびGdーDTPAの影響" 日本医学放射線学会雑誌. 51. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 宗治: "MRIー最近の進歩(巻頭言)" 臨床成人病. 21巻3号. (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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