| Project/Area Number |
02454285
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
MORIRA Rikushi Shiga University of Medical Science Radiology, Professor, 医学部, 教授 (60026896)
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| Co-Investigator(Kenkyū-buntansha) |
OHNAKA Yasuo Shiga University of Medical Science Radiology, Research Associate, 医学部, 助手 (80213792)
YAMAMOTO Itsuo Shiga University of Medical Science Radiology, Associate Professor, 医学部, 助教授 (60115962)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1991: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1990: ¥6,600,000 (Direct Cost: ¥6,600,000)
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| Keywords | Osteoporosis / Fracture / Bone Mineral Density / DEXA / Ultrasound Velocity / DEXA / QCT / SPA / 脊椎骨圧迫骨折 |
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| Research Abstract |
Vertebral fracture threshold was determined by measuring lumbar bone mineral densities (BMD) using dual energy absorptiometry (DEX A). Lumbar bone mineral measurement is useful for predicting vertebral fractures in relatively young patients, and however, it is worthless for patients over age of 70. In older patients, peripheral bone measurement or whole body bone measurement has much advantage because of relatively free from degenerative skeletal changes, especially for monitoring effects of therapy.
Measurement of calcaneal bone by single X-ray absorptiometry (SXA is accurate and reproducible. Furthermore, density of calcaneal bone correlates well with femoral neck BMD and lumbar BMD. Thus, measurement-of calcaneal bone by SXA would be an alternative way to monitor bone in older people. Although BMD correlates well with an occurrence rate of fractures, a significant overlap was observed between fractured and non-fractured. Thus, another factors other than BMD should exist. For evaluating such factors, bone quality should be examined by other methods such as measurement of ultrasound velocity, by which some preliminary data show interesting results.
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