| Project/Area Number |
02454296
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | University of Tokyo |
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Principal Investigator |
SATO Osamu (1992) Tokyo Uni., Surgery, Director, 医学部(病), 助手 (40170724)
多田 祐輔 (1990-1991) 東京大学, 医学部(病), 助教授 (70010246)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Akira Tokyo Uni., Surgery, Associate, 医学部(病), 助手 (00233099)
SHINDO Shyunya Tokyo Uni., Surgery, Associate, 医学部(病), 助手 (50206322)
SHIRAKAWA Motoaki Tokyo Uni., Surgery, Associate, 医学部(病), 助手 (20211295)
EGAMI Jyun Tokyo Uni., Surgery, Associate, 医学部(病), 助手 (80232932)
古屋 隆俊 東京大学, 医学部(病), 助手
佐藤 紀 東京大学, 医学部(病), 助手 (40170724)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1992: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1991: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | endothelial cell seeding / prelined graft / hybrid-type vascular prosthesis / small caliber vascular prosthesis / endothelial cell / Endothelial Cell Seeding / Predined graft / Endothelial cell seeding / Prelined graft |
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| Research Abstract |
A small caliber vascular prosthesis remains unsatisfactory in regard with the long term patency rate. A hybrid vascular prosthesis has been investigated for achieving the better patency in the way of combining the living cells with a synthetic graft. We studied the endothelial cells (ECs) seeding to the ultrafine polyester fiber grafts and developed the filtration seeding method in order to utilize a large number of cells. The in vitro and in vivo study revealed that the ECs grew up around the grafts with time and maintain the continuous monolayer of the ECs three months after implantation. However, at the anastomotic sites, the ECs monolayer was formed on the thick subendothelial tissue which continued to the thick intima of the host artery. The ECs seeding only may not be enough to prevent the graft failure. The intimal hyperplasia may be the major target for achieving the better patency of the small caliber vascular prosthesis in the following research.
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