| Project/Area Number |
02454318
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
TAKAHASHI Toshio KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, 第一外科, 教授 (50079828)
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| Co-Investigator(Kenkyū-buntansha) |
HAGIWARA Akeo Hagiwara,Dept. of Surgery Assistant, 第一外科, 助手 (90198648)
YAMAGUCHI Toshiharu Yamaguchi,Dept. of Surgery Lecturer, 第一外科, 講師 (90111327)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1992: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1991: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1990: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | Missile Therapy / Monoclonal Antibody / Chimeric Antibody / Colon Cancer / HAMA / モノクロ-ナル抗体 / 抗癌剤 / 膵癌 / ポリエチレングリコ-ル / 癌化学療法 / ネオカルチノスタチン |
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| Research Abstract |
Monoclonal antibody-drug conjugate,A7-NCS,was applied for 80 patients with colorectal and pancreatic cancer, including metastasis of liver, lung and peritoneum. Fifty-four patients with colon cancer, fifteen patients with postoperative liver metastasis of colorectal cancer and one patient with advanced pancreatic cancer ware given A-NCS intra-arterially. Two patients with postoperative lung metastasis of colon cancer were injected intra-venously and one patient with postoperative peritoneal metastasis of colon cancer was given it intraperitoneally. Three patients with liver metastasis showed evidence of tumor reduction on CT scan and three claimed pain relief. Postoperative survival of the patients with distant metastasis exhibited slightly higher survival rate in the patients with A7-NCS, as compared with the patients without A7-NCS. There was no serious adverse effect in the patients given A7-NCS.Human anti-body(HAMA)was detected in all patients given the conjugate. Repeated injections of A7-NCS for several consecutive days following the first injection brought about the same A pattern as the first injection. Chimeric monoclonal antibody A7 and its conjugate chimeric A7-NCS were successfully produced.
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