| Project/Area Number |
02454335
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | NIIGATA UNIVERSITY |
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Principal Investigator |
TANAKA Ryuichi NIIGATA UNIVERSITY・BRAIN RES.INST., PROFESSOR, 脳研究所, 教授 (30018816)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Norio NIIGATA UNIVERSITY・BRAIN RES.INST., ASSISTANT PROFESSOR, 脳研究所, 助教授 (20150302)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥5,300,000 (Direct Cost: ¥5,300,000)
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| Keywords | Hypothalamus / Neuroimmunomodulation / Lymphocyte subset / Natural killer activity / Immunological memory / Flowcytometry / Rat / hypothalamus / immune response / rat / immunological memory / flow cytometry / lymphocyte subset / natural killer activity |
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| Research Abstract |
We have previously identified the suppression of the lymphocyte blastogenesis and the acceleration of the growth of the subcutaneous tumors by bilateral anterior hypothalamic lesions in rats. The present study was performed to clarify the changes in the lymphocyte subsets and the NK activity after making the lesions. The influence on the immunological memory was also studied. CD4 to CD8 ration of the peripheral blood lymphocytes and spleen cells. T cell receptor alpha beta positive cells of the thymocytes and NK activity of the spleen cells have decreased significantly. MHC antigen expressions on the RBL-1 cells intraperitoneally injected to the preimmunized rats were also suppressed. These results suggest that the anterior hypothalamus has some influences on the control of the cellularimmunological functions at the peripheral level, on the maturation of T cells at the level of thymus and on the antigen recognition by T cell receptors and MHC antigens.
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