• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Experimental Study for Pathophysiology of Cauda Equina and Nerve Root.

Research Project

Project/Area Number 02454340
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionAsahikawa Medical College

Principal Investigator

HARADA Yoshio  Asahikawa Medical College Orthopaedics assistant prof, 医学部, 助教授 (40001937)

Co-Investigator(Kenkyū-buntansha) KAMO Y  Asahikawa Medical College Orthopaedics instructor, 医学部, 助手 (50214565)
IWAHARA T  Asahikawa Medical College Orthopaedics instructor, 医学部, 助手 (80133817)
ATSUTA Y  Asahikawa Medical College Orthopaedics instructor, 医学部, 助手 (90167924)
TAKEMITSU Y  Asahikawa Medical College Orthopaedics prof., 医学部, 教授 (00038663)
平山 隆三  旭川医科大学, 医学部, 講師 (10110644)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1992: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1991: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1990: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsnerve root / ectopic firing / hypoxia / compression / neurophysiology / in vitro preparation / invitro標本 / 神経節 / 化学受容器 / 神経伝達物質 / 神経根性疼痛 / radicular pain / radicular compression / sensory fiber
Research Abstract

It has been recently suggested that the pain and dysesthesiadue to lumbar nerve root lesion is originated from not only mechanical compression but also chemical factors around the nerve root. In the present study, the nerve root with sensory ganglia was prepared from adult dog and was immersed in the bathing chamber filled with artificial cerebrospinal fluid (aCSF). And the analysis was made from a view point of ectopic firing. This experimental model revealed that the sensory ganglia is sensitive to weak mechanical compression and hypoxia. The nerve root was sensitive to substance P. chondroitin sulfate, degenerated discextract, etc. but not to bradykinin, prostaglandins. It was also shown that methyl B12, eperisone and some coriticosteroid has an inhibitory effect on the ectopic discharges. Chronic compression produced the degenerative changes of the nerve root and chemical sensitivity was also modulated. From these results, it was concluded that the model used was quite useful to understand the pathophysiology of the lumbar nerve root lesions.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] 原田 吉雄: "術中脊髄機能モニタリングのpitfall" 日本整形外科学会雑誌. 66. S189 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 熱田 裕司: "神経根症状の発現様式解明の関する実験的研究" 日本整形外科学会雑誌. 66. S1171 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岩原 敏人: "in vitroにおける脊髄誘発電位の実験的検討" 日本整形外科学会雑誌. 66. S1411 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Iwaharo: "Analysis of spinal cord evoked potential and locomotor function during acute spinal cord compression" Spine. 66. 1375-1380 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 菅原 修: "神経根に及ぼす機械的圧迫と低酸素負荷の影響" 北海道整形災害外科雑誌. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Atsuta: "Mucle relaxation:recent4therapeutic advances" Jun kimura,Taclaaki Manoed., 167 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Harada: "Pitfall of intraoperative spinal cord monitoring" Journal of Japanese Orthopaedic Association. 66. S189 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Atsuta: "Experimental research for pathophysiology of nerve root" Journal of Japanese Orthopaedic Association. 66. S1171 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Iwahara: "In vitro study of spinal cord evoked potentials" Journal of Japanese Orthopaedic Association. 66. S1411 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Iwahara: "Analysis of spinal cord evoked potential and locomotor function during acute spinal cord compression" Spine. 66. 1375-1380 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Sugawara: "The effect of mechanical compression and hypoxia on nerve root" Hokkaido Journal of Orthopaedic Traumat. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 原田 吉雄: "術中脊髄機能モニタリングのpitfall" 日本整形外科学会雑誌. 66. S189- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 熱田 裕司: "神経根症状の発現様式解明に関する実験的研究" 日本整形外科学会雑誌. 66. S1171- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岩原 敏人: "in vitro モデルにおける脊髄誘発電位の実験的検討" 日本整形外科学会雑誌. 66. S1411- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Iwahara: "Analysis of spinal cord evoked potential and locomotor function during acute spinal cord compression" Spine. 66. 1375-1380 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 菅原 修: "中経根に及ぼす機械的圧迫と低酸素負荷の影響" 北海道整形災害外科雑誌. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Atsuta: "Muscle relaxation:vecenttherapeutic advances" Jun Kimura,Tadaaki Maro ed., 167 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 原田 吉雄 他: "術中脊髄モニタリングにおけるpitfallsとその対策" 整形災害外科. 34. 39-44 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 加茂 裕樹 他: "Pedicular screwingによる合併症とその予防に関する考察" 別冊整形外科. 20. 249-254 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Atsuta,Y.他: "Control of locomotion in vitro:11.Chemical stimulation" Somatosens and Motor Res.8. 45-53 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 熱田 裕司 他: "in vitro脊髄後肢標本に於けるpainーspasm reflex" 日本整形外科学会雑誌. 65. S1382 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 熱田 裕司 他: "脊椎疾患関連領域における研究手法としての神経in vitroモデルの応用" 日本脊椎外科学会雑誌. 2. 253 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Iwahara,T.他: "Locomotion induced by spinal cord stimulation in the neonate rat in vitro." Somatosens and Motor Res.8. 281-287 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 原田 吉雄: "自動脊髄モニタリング(SAFE)の開発と臨床応用" 臨床脳波. 32. 648-653 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 原田 吉雄: "術中脊髄モニタリングにおけるPitfallsとその対策" 整形災害外科. 34(1). 39-44 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 原田 吉雄: "電気刺激による筋力強化" 総合リハビリテ-ション. 18. 767-772 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 魏 新栄: "伝導性脊髄誘発電位に関する実験的研究ー運動路系の関与についてー" 北海道整災誌. 33(2). 1-7 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 浜田 修: "術中脊髄モニタリングにおけるPitfallとその対策" 脊髄電気診断学. 12(1). 149-152 (1990)

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi