• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Myeloid cell cascade bearing onco-fetal membrane structure found in the involved epiphyseal bone marrow in patients with severe active rheumatoid arthritis

Research Project

Project/Area Number 02454345
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionOsaka University

Principal Investigator

OCHI Takahiro  MD,Osaka University Medical School Dept of Environmental Medicine, Professor, 医学部, 教授 (80112035)

Co-Investigator(Kenkyū-buntansha) KIMURA Tomoatu  MD,Osaka University Medical School Department of Orthopedics, Lecturer, 医学部, 講師 (80167379)
ONO Keiro  MD,Osaka University Medical School, Department of Orthopedics, Professor, 医学部, 教授 (70028330)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1990: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsrheumatoid arthritis / iliac bone marrow / epiphyseal bone marrow / myeloid cells / activated CD8(+) T cells / IL-6,-8 / 関節破壊 / 重症病型 / MY4抗原 / GMCSF / 特異な骨髄球系カスケ-ド / MY4(+) / 組織破壊活性 / ILー1
Research Abstract

Main purpose is to study the role of bone marrow in inducing or persisting poly-arthritis like rheumatoid arthritis. In experimental polyarthritis, pathological changes were seen primarily in bone marrow. Preceding the beginning of synovial proliferation, the cellular development and proliferation of bone marrow cells and the elevation of IL-1 and -6 could be observed in bone marrow. Thus, the role of bone marrow in inducing polyarthritis were impressed.
In the persistent severe inflammatory process of RA, some uncontrollable proliferation of a certain type of undifferentiated cells could be accompanied by destruction and disorganization of normal cells. We found an accumulation of abnormal myeloid lineage bearing aberrant carbohydrate membrane structures in the bone marrow of patients with severe active rheumatoid arthritis. Polymorphonuclear leukocytes, mature cells of myeloid lineage, accumulating in these lesions were found to contain unususally high levels of IL-1.
We further survey … More ed bone marrow of ilium as a systemic hemopoietic organ. In iliac bone marrow, numbers of each mononuclear cell fractions were highly significantly increased. The increase of activated (HLADR+) CD8 cells were significant. in iliac bone marrow of RA patients with both severe and mild natural course. The increase of myeloid cells in iliac bone marrow was significant in patients with severe destructive disease of RA. The abnormal myeloid cells primarily found in the epiphyseal bone marrow were found to accumulate much more in the iliac bone marrow of patients with severe destructive RA.
Cytokines were also surveyed in bone marrows. In the iliac bone marrow of RA patients, elevation of IL-6, and IL-8 were characteristically found. The elevation of these cytokines in peripheral blood were also found, but the levels were much less than those in the iliac bone marrow. Interestingly, the elevation of IL-6, -8 showed close relationships with exacerbation of synovitis in multiple joints.
Thus, in RA patients, iliac bone marrow could be a primarily important lesion, and could influence the peripheral blood and epiphyseal bone marrow. We are further surveying the roles of bone marrow in inducing RA. Less

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Hayashida,K.,Ochi,T,Ono K. et al: "Bone marrow changes in adjubant-induced and collagen-inducedarthritis" Arthritis and Rheumatism. Vol35. 241-245 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Fujimoto,M.,Hayashida,K.,Ochi,T. et al: "Fluctyation of interleukin-1 and -6 activity in bone marrow serroe serum in collagen-induced arthritis in rats" Biomedical Research. 13(4). 243-251 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kaisho,T.,Oritani,K.,Ochi,T. et al: "Human bone merrow stromal cell lines from myeloma and rheumatoidarthritis that can support murine PRE-B cell growth" The Journal of Immunology. Vol.149. 4088-4095 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yukioka,K.,Wakitani,S.,OCHI,T.et al: "Polyamine levels in synovial tissues and synovia fluids of patients with rheumatoid artheitis" The Journal of Rheumatology. 19:5. 689-692 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 越智 隆弘: "骨髄の研究" 平成3年度厚生省リウマチ調査研究事業研究報告書. 75-78 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 越智 隆弘: "RA患者骨髄中の骨髄球系細胞" 平成3年度厚生省リウマチ調査研究事業研究報告書. 79-82 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.FUJIMOTO, K.HAYASHIDA, T.OCHI, H.OWAKI, Y.SHIMAOKA, M.OKAMURA, K.ONO: "Fluctuation of interleukin-1 and -6 activity in bone marrow serum in collagen-induced arthritis in rats" Biomedical Research. 13(4). 243-25 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.HAYASHIDA, T.OCHI, M.FUJIMOTO, H.OWAKI, Y.SHIMAOKA, K.ONO, K.MATSUMOTO: "Bone marrow changes in adjuvant-induced and collagen-Induced atrhritis" Arthritis and Rheumatism. 35(2). 241-245 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.OWAKI, K.YUKAWA, T.OCHI, Y.SHIMAOKA, K.ONO: "Facs analysis of myeloid differentiation stages in epiphyseal bone marrow, adjacent to joints affected with rheumatoid arthritis" Scand J Rheumatol. 20. 91-97 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.YUKIOKA, S.WAKITANI, M.YUKIOKA, Y.FURUMITSU, K.SHICHIKAWA, T.OCHI, H.GOTO, I.MATSUI-YUASA, S.OTANI, Y.NISHIZAWA, H.MORII: "Polyamine levels in synovial tissues and synovial fluids of patients with rheumatoid arthritis" The Journal of Rheumatology. 19(5). 689-692 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.KAISHO, K.ORITANI, J.ISHIKAWA, M.TANABE, O.MURAOKA, T.OCHI, T.HIRANO: "Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-b cell growth" The Journal of Immunology. 149(12). 4088-4095 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hayashida,K.,Ochi,T Ono K, et al: "Bone marrow changes in adjubant-induced and collagen-induced arthritis" Arthritis and Rheumatism. Vol35. 241-245 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Fujimoto,M.,Hayashida,K.,Ochi,T.et al: "Fluctuation of interleukin-1 and-6 activity in bone marrow serum in collagen-induced arthritis in rats" Biomedical Research. 13(4). 243-251 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kaisho,T.,Oritani.K.,Ochi,T. et al: "human bone marrow stromal cell lines from myeloma and rheumatoidarthritis that can support murine PRE-B cell growth" The Journal of Immunology. Vol.149. 4088-4095 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yukioka,K.,Wakitani,S.,OCHI,T. et al: "Polyamine levels in synovial tissues and synovia fluids of patients with rheumatoid arthritis" The Journal of Rheumatology. 19:5. 689-692 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 越智 隆弘: "骨髄の研究" 平成3年度厚生省リウマチ調査研究事業研究報告書. 75-78 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 越智 隆弘: "RA患者骨髄中の骨髄球系細胞" 平成3年度厚生省リウマチ調査研究事業研究報告書. 79-82 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ochi T,Iwase R,Kimura T,et al.: "Effect of early synovectomy on the course of rheumatoid arthritis" Journal Rheumatology. 18. 1794-1798 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hayasida K,Fujimoto M,Ochi T,et al: "Bone marrow changes in adjuvandーinduced and collagenーinduced arthritis" Arthritis Rheumatism. 14. 48-55 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 越智 隆弘: "骨髄と慢性関節リウマチ" 感染、炎症、免疫. 22. 21-30 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 越智 隆弘,木村 友厚: "リウマチの治療:原因解明の研究" 治療. 73. 67-72 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 越智 隆弘: "慢性関節リウマチの原因は骨髄にもあるか" 医学のあゆみ. 160. 442-445 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 越智 隆弘,田辺 鎮雄,藤本 真弘,小野 啓郎: "同種胸腺移植によるマウス多発関節炎における発症と増悪の要因" 臨床免疫. 23. 1419-1427 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] S Wakitani,T Ochi,Y Shimaoka,K Ono: "ELEVATED LEVEL OF INTERLEUKINー1 IN POLYMORPHONUCLEAR CELLS ACCUMULATING IN BONE MARROW ADJACENT TO THE AFFETED JOINT IN PATIENTS WITH RA." The Journal of Rheumatology.

    • Related Report
      1990 Annual Research Report
  • [Publications] T Ochi,S Wakitani,Y Shimaoka,K Ono: "ELEVATED ACTIVITY OF INTERLEUKINー1 IN EPIPHYSEAL BONE MARROW ADJACENT TO AFFECTED JOINTS WITH RHEUMATOID ARTHRITIS" 54th ANNUAL MEETING AMERICAN COLLEGE OF RHEUMATOLOGY OCTOBER 27ーNOVEMBER 1,1990 SEATTLE,WASHINGTON.

    • Related Report
      1990 Annual Research Report
  • [Publications] 島岡 康則、越智 隆弘、岡村 まさ恵、小野 啓郎: "慢性関節リウマチ患者にみられる特異的骨髄球について" 第34回日本リウマチ学会総会 平成2年5月29・30・31.

    • Related Report
      1990 Annual Research Report
  • [Publications] 脇谷 滋之、越智 隆弘、島岡 康則、林田 賢治、木村 友厚、小野 啓郎: "ムチランス型慢性関節リウマチの罹患関節近傍骨髄中多型核白血球に認められたインタ-ロイキン1活性" 第34回 日本リウマチ学会総会 平成2年5月29・30・31.

    • Related Report
      1990 Annual Research Report
  • [Publications] 島岡 康則、越智 隆弘、小野 啓郎: "重症慢性関節リウマチ患者の組織破壊と関連する特異的骨髄球及びその維持因子" 第5回 日本整形外科学会基礎学術集会 平成2年10月3・4・5.

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi