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Motor Evoked Potentials induced with Transcranial Magnetic Brain Stimulation

Research Project

Project/Area Number 02454348
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKansai Medical University

Principal Investigator

KAMEYAMA Osamu  Kansai Med Univ, Dept. of Orthop. Surg, Associate professor, 医学部・整形外科, 助教授 (50148516)

Co-Investigator(Kenkyū-buntansha) MORI Yoshiki  Kansai Med Univ, Dept. of Orthop. Surg, Assistant professor, 医学部・整形外科, 講師 (30077755)
OGAWA Ryokei  Kansai Med Univ, Dept. of Orthop. Surg, Professor, 医学部・整形外科, 教授 (90077610)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1992: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1991: ¥600,000 (Direct Cost: ¥600,000)
Keywordsmagnetic stimulation / motor cortex / evoked potential / spinal cord injury / conduction time / latency / spinal cord / evoked potential / magnetic stimulation
Research Abstract

Motor evoked potentials (MEPs) induced by magnetic brain stimulation were investigated to clarify the usefulness for an acute spinal cord injury. 25 rabbits were employed for this acute spinal cord injured model. The MEPs from the tibialis anterior muscle (M-MEP) were recorded with bipolar electrodes : prior to the injury ; just immediately after the injury ; 30 min, 1 hour, 3 hours and 5 hours respectively after the injury. The MEPs from spinal cord (S-MEP) were recored at the proximal and distal part of the injured site with epidural tube electrodes. Subjects were divided into two groups ; complete and incomplete paralysis, according to the degree of motor dysfunction at 1 week after the injury. All of the subjects with incomplete paralysis showed the prolongation of the M-MEP latency and polyphasic wave form was seen, immediately after the trauma. Infiltration of the inflammatory cells and diffuse hemorrhage were seen at the gray matter in the injured spinal cord in the incomplete g … More roup. In compete paralysis cases, the M-MEP was disappeared within 3 hours and histopathologically, large area of the nerve cells were disappeared at the gray matter in this group. On the other hand, the S-MEP disappeared just after trauma in the group with complete paralysis as well as the incomplete paralysis group. This study indicated that the MEPs have some possibilities to detect the severity of the spinal cord injury and to evaluate of prognosis of motor function in patients with spinal cord injury at an acute phase.
In clinical study we have examined the MEPs in 35 normal subjects and 126 patients ; 67 cases with cervical spondylotic myelopathy ; 24 cases with spinal canal stenosis ; 35 cases with spinal cord injury. The stimulator coil was placed on the vertex and then the MEPs were evoked by transcranial motor cortex stimulation during relaxd position and during the remote muscle contraction. Special consideration was focused on the silent period after the MEPs during the maximum voluntary contraction of the target muscle. The results showed that the central motor conduction time correlated with the clinical evaluation in the myelopathy patients and that the abnormality of the conduction time was not observed in the spinal canal stenosis patients. During the maximum voluntary contraction of the target muscle, the consistent silent period was observed after the MEPs in the normal subjects, but this duration remarkably shortened in the myelopathy patients. Less

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] 亀山 修: "経皮的大脳運動野電磁気刺激法による下行性運動路の評価" 中部整災誌. 34. 1776-1800 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 川北 浩史: "経皮的大脳磁気刺激法における脊髄急性圧迫実験第1報 家兎脊髄誘発電位に与える影響" 中部整災誌. 34. 1571-1572 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 亀山 修: "経皮的電磁気刺激法により誘発されたMEP_S最短潜時について" 脊髄電気診断学. 13. 101-104 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 亀山 修: "脊髄損傷に対する電磁気刺激法" 脊髄電気診断学. 12. 117-120 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 亀山 修: "経皮的大脳運動野刺激法-刺激部位とMEP_S" 中部整災誌. 33. 644-647 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 柴野 恵介: "被験筋最大収縮時のMEP_S-MEP_S後のsilent periodについて" 中部整災誌. 35. 643-644 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, P.Johonson, K.Hays, D.Wolfe, R.Allatt, J.Hsich: "Transcranial magnetic stimulation of the human brain" J.Biomechanics. 22 (10). 1032 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Miyagawa, K.Hays, D.Wolfe, O.Kameyama: "Electromyographic responses in upper extremities induced by magnetic stimulation" J.Biomechanics. 22 (10). 1058 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Kawakita, O.Kameyama, R.Ogawa, K.Hays, D.Wolfe, R.Allatt: "Reinforcement of motor evoked potentials by remote muscle contraction" J Electromyogr. Kinesiol.1. 96-106 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, R.Ogawa, M.Kumamoto: "Sports injuries in terms of biarticular muscle function" Human Movement Science. (in print). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, H.Kawakita, R.Ogawa: "Evaluation of motor function with MEPs in response to transcranial magnetic stimulation" Spine, (in submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, D.Wolfe, K.Hays: "Non-invasive magnetic stimulation." J Musculoskeletal System. 2. 551-558 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, H.Kawakita, K.Hays, D.Wolfe: "Transcranial motor cortex stimulation in the functionally complete spinal cord injured patient" J Electrodiagnosis of the spinal cord. 12. 117-120 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, H.Kawakita, R.Ogawa, K.Hays: "Transcranial electromagnetic stimulation for spinal cord injured patients" Cent Jpn J Orthop Traumat. 33. 2012-2014 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, H.Kawakita, D.Wolfe, P.Johuson, K.Hays: "Motor evoked potentials by transcranial electromagnetic stimulation-effects of stimulation conditions" Cent Jpn J Orthop Traumat. 33. 644-647 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Kawakita, O.Kameyama, R.Ogawa, K.Hays, D.Wolfe: "Transcranial magnetic stimulation-influence of remote muscle contraction." Gent Jpn J Orthop Traumat. 33. 2010-2012 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Kawakita, O.Kameyama, R.Ogawa: "Motor evoked potential in experimental acute spinal cord injury" Gent Jpn J Orthop Traumat. 34. 1571-1572 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, H.Kawakita, K.Shibano, Y.Yamamoto, R.Ogawa: "Magnetoelectric stimulation of the motor cortex-minimum latency of MEPs." J Electrodiagnosis of the spinal cord. 13. 101-104 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Kawakita O.Kameyama, R.Ogawa: "Electromagnetic stimulation of the human motor cortex-effects of the facilitation maneuvers" J Electrodiagnosis of the spinal cord. 13. 105-110 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, H.Kawakita, R.Ogawa: "Transcranial electromagnetic stimulation in spinal cord disorders" Gent Jpn Orthop Traumat. 34. 1796-1800 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, H.Kawakita, R.Ogawa: "Silent period on the ongoing the EMG induced by transcranial electromagnetic brain stimulation." J Electrodiagnosis of the spinal cord. 14. 96-99 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Mori, H.Kawakita, O.Kameyama, R.Ogawa: "A clinical study on ADL criteria of the upper limb of cervical myelopathy patients under the magnetic transcranial motor evoked potentials" Cent Jpn J Orthop Traumat. 35. 1149-1150 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Kawakita, O.Kameyama, R.Ogawa: "Clinical evaluation of cervical myelopathy ; neuroradiological and electrophysiological assessment" J Electrodiagnosis of the spinal cord. 14. 156-160 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] O.Kameyama, Y.Yamamoto, K.Sasai, H.Kawakita, R.Ogawa: "Clinical study of MRI and MEPs for cervical myelopathy" J Electrodiagnosis of the spinal cord. 15. 88-92 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 亀山 修: "経皮的大脳運動野電磁気刺激法による下行性運動路の評価" 中部整災誌. 34. 1796-1800 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 川北 浩史: "経皮的大脳磁気刺激法における脊髄急性圧迫実験第一報.家兎脊髄誘発電位に与える影響" 中部整災誌. 34. 1571-1572 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 亀山 修: "経皮的電磁気刺激法により誘発されたMEPs最短潜時について" 脊髄電気診断学. 13. 101-104 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 亀山 修: "脊髄損傷に対する電磁気刺激法" 脊髄電気診断学. 12. 117-120 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 亀山 修: "経皮的大脳運動野刺激法ー刺激部位とMEPs" 中部整災誌. 33. 644-647 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 柴野 恵介: "被験筋最大収縮時のMEPs MEPs後のsilent periodについて" 中部整災誌. 35. 643-644 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 亀山 修ら: "経皮的大脳運動野電磁気刺激法による下行性運動路の評価" 中部日本整形災害外科学会誌. 34. (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 川北 浩史ら: "脊髄損傷急性期における経頭蓋的大脳磁気刺激誘発電位について:家兎急性脊髄圧追実験" 日本整形外科学会誌. 65. 1030 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 亀山 修: "運動誘発電位による下行性運動路の評価:パラメ-タの検討" 日本整形外科学会誌. 65. 1060 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 川北 浩史: "経頭蓋的大脳電磁気刺激法における脊髄急性圧迫実験.家兎脊髄内誘発電位に与える影響について" 中部日本整形災害外科学会誌. 34. 1571-1572 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Kawakita: "Reinforcement of motor evoked potentials by remote muscle contraction" J.Electromyogr.Kinesiol.1. 96-106 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 亀山 修: "脊椎損傷に対する大脳運動野電磁気診断法" 脊髄電気診断学. 12. 117-120 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 川北 浩史: "経頭蓋的大脳電磁気刺激法における脊髄急性圧迫実験 第1報:家兎脊髄内誘発電位に与える影響" 第76回中部日本整形災害外科学会発表予定平成3年5月24日.

    • Related Report
      1990 Annual Research Report
  • [Publications] 亀山 修: "経友的大脳運動野刺激法:刺激部位とMEPs" 中部日本整形割害外科学会誌. 33. 644-647 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kameyama,O.et al.: "Transcranial magnetic stimulation of the human brain" J.Biomechanics. 22. 1032 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 川北 浩史: "経頭蓋的電磁気刺激法による誘発電位 遠隔筋収縮の促進効果について" 中部日本整形災害外科学会誌. 33. 2010-2012 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 亀山 修: "経頭蓋的電磁気刺激法によるMEP;最短潜時について" 脊髄電気診断学. 13. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 亀山 修: "脊髄損傷患者に対する大脳運動野刺激法と促通法" 中部日本整形災害外科学会誌. 33. 2012-2014 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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