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Research to develop an artificial lung for intravenous lung assist

Research Project

Project/Area Number 02454357
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionKumamoto University

Principal Investigator

MORIOKA Tohru  Kumamoto university Medical School Dept. of Anesth. Professor, 医学部, 教授 (30040140)

Co-Investigator(Kenkyū-buntansha) OTSU Tetsuro  Kumamoto university Medical School Dept. of Anesth. Instructor, 医学部附属病院, 構師 (40152178)
OKAMOTO Kazufumi  Kumamoto university Medical School Intensive Care Univ. Associate Professor, 医学部附属病院, 助教授 (60093994)
TERASAKI Hidenori  Kumamoto university Medical School Dept. of Anesth. Associate Professor, 医学部, 助教授 (30040562)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1991: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥4,900,000 (Direct Cost: ¥4,900,000)
Keywordsblood gases / artificial lung / intravenous lung assist / hollow fiber lung / respiratory failure / IVOX
Research Abstract

This project was aimed at the development of a simple and nonivasive artificial lung for intravenous blood gas exchange in patients with respiratory failure.
The lung is made of a bundle of several hundreds of curled hollow-fibers, about 20cm in length. A long oxygen-delivery tube in placed in the center of the bundle. The distal end of the hollow-fibers are opened to a chamber where oxygen is delivered through the central tube. The proximal ends of the hollow fibers are gathered to a gas collecting chamber, which is connected to a suction tube concentrically running outside of the oxygen-delivery tube. Oxygen is delivered to the hollow fibers by negative pressure applied to the suction catheter.
The lung and adjacent part of the tubes are inserted into the vena cava via the right jugular vein or a femoral vein. A vibration pump with a flowmeter and a manometer to measure negative pressure were newly developed to ventilate the hollow-fiber lung by suction. Various sizes of lungs were produced, but miniaturization, without losing gas exchange efficacy, was difficult to attain. Animal experiments show that this lung leaves much to be improved for real safety.
The idea to insert in turn a delivery tube and bundles of hollow fibers into a vein, then compose an artificial lung in the blood vessel, was born. Though it is difficult to realize with the current technolgy, it will become a very useful means of incorporating artificial organs in a blood vessel.
More than 100 patients have undergone IVLA in the U. S. A. and Europe. Thrombosis, hemorrhage, difficult removal of the lung, etc are the problems to be solved. When both extracorporeal and intravenous lung assist are improved, it will be difficult to decide which is more appropriate for patients with mild respiratory failure.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] 森岡 亨: "ECLHA(ECMO;体外式心肺補助法)" 集中治療. 3. 213-219 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 森岡 亨: "静脈内留置人工肺" 呼吸. 10. 278-282 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 森岡 亨: "長時間生命維持法における人工肺" 人工臓器. 20. 377-380 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 寺崎 秀則: "Extracorporeal lung and heart assist with the artificial membrane lung in Japan" Artificial Organs Today. 1. 115-127 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 崔 賢: "静脈内留置式人工肺に関する研究" 医工学治療III. 152-154 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 森岡 亨: "ECMOの基礎と臨床への展開" 人工臓器. 21. 20-25 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 森岡 亨: "呼吸器疾器 State of Arts" 医歯薬出版, 490 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tohru Morioka, Hidenori Terasaki: "The first attempt of CO_2 removal with an artificial heart-lung machine-revisited a quater century later-" J Anesth. 5. 103-104 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tohru Morioka, Hidenori Terasaki: "ECLHA (ECOM : extracorporeal lung assist)." Intensive care (Jpn). 3. 213-219 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tohru Morioka: "Intravenous artificial lung." Kokyu (Respiration). 10. 278-282 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hidenori Terasaki, Tohru Morioka, Hiroshi Motoyama, Kazuhiko Ogata, Tsuguhisa Isa, Tatsunori Tobimatsu: "The first successful case of CO_2 removal with an artificial heart lung machine on a patient with severe respiratory failure at Kumamoto University Medical School." Kumamoto to Medical J. Kumamoto University. 42. 113-119 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tetsuro Otsu, et al: "38 days of ECLA on a patient with viral pneumonia after measles." Jpn J Artif Organs. 20. 1124-1128 (1191)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hidenori Terasaki, Tohru Morioka: "Extracorporeal lung and heart assist with the artificial membrane lung in Japan." Artif Organ Today. 1. 115-127 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kook-Hyun Lee, Kwan Woo Kim, Hidenori Terasaki, Tohru Morioka: "The effect of venoveno us extracorporeal lung assist on the oxygenation of mixed venous blood." Korean J Anesth. 24. 1-10 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hyun Choi, et al: "Improvement of hollow-fibers for prolonged ECLA." Jpn J Medical Technolog Therapeutics. 3. 149-151 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hyun Choi, et al: "Research on intravenous artificial lung." Jpn J Medical Technolog Therapeutics. 3. 152-154 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tetsuro Otsu, Hidenorio Terasaki, Kyoji Tsuno, Yasushi Kishi, Mari Nakamura, Kimiaki Ezaki, Taisuke Okamoto, Akira Hashiguchi, Yong-Kyun Chung, Suzuhiko Mizoguchi, Kazuo Suzuki Michiko Urata, Toru Tajima, Kenichiro Taki, Tohru Morioka: "Successful use of a double lumen catheter as blood access for venovenous extracorporeal lung assist." Artif Organ Today. 1. 253-255 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tohru Morioka: "Fundamentals and Clinical Application of ECMO." Jpn J Artif Organs. 21. 38-42 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tohru Morioka, et al: "Heparin-bonded dense membrance hollowfiber artificial lung with the external perfusion system and its application to ECLA for infants." Jpn J Membrane Artif Lung. 15. 69-72 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tohru Morioka: "How a membrane artificial lung is used in the treatment of ARDS ?" Hideo Yamamura ed. Handbook for clinician.Medical View Pub. Co. Tokyo. 130-131 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tohoru Morioka: "ECLA, ECMO-Respiratory care with an artificial lung." Michiyosh Harasawa ed. Respratory deseases.Medical Dental Pharma Pub Co. Tokyo. 287-290 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tohru Morioka: "ECCO_2 R, ECL (H) A-Specific blood gas exchange." Masakazu Tsuzuki ed. Respiratory assistance.Kanahara Pub Co. Tokyo. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 森岡 亨: "ECLHA(ECMO;体外式心肺補助法)" 集中治療. 3. 213-219 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 森岡 亨: "静脈内留置人工肺" 呼吸. 10. 278-282 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 森岡 亨: "長時間生命維持法における人工肺" 人工臓器. 20. 377-380 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 寺崎 秀則: "Extracorporeal lung and heart assist with the artificial membrane lung in Japan" Artificial Organs Today. 1. 115-127 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 崔 賢: "静脈内留置式人工肺に関する研究" 医工学治療III. 152-154 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 森岡 亨: "ECMOの基礎と臨床への展開" 人工臓器. 21. 20-25 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 森岡 亨: "呼吸器疾患 State of Arts" 医歯薬出版, 490 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 森岡 亨: "IVOXについて ECMOその現状と未来" NICU. 3. 971-975 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 丁 栄均: "大量のメシル酸ナファモスタットによるECLA時血液能凝固調節" 医工学治療. 2. 206-208 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 丁 栄均: "ヘパリン結合小型高性能模型人工肺の開発" 医工学治療. 2. 274-277 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 森岡 亨: "静脈内留置式血液ガス交換法" 臨床麻酔. 14. 1149-1155 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 寺崎 秀則: "ヘパリン結合MAXIMA人工肺と回路によるECLHAの急性重症心肺不全治療への応用" 膜型肺. 13. 91-96 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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