| Project/Area Number |
02454357
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
麻酔学
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
MORIOKA Tohru Kumamoto university Medical School Dept. of Anesth. Professor, 医学部, 教授 (30040140)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OTSU Tetsuro Kumamoto university Medical School Dept. of Anesth. Instructor, 医学部附属病院, 構師 (40152178)
OKAMOTO Kazufumi Kumamoto university Medical School Intensive Care Univ. Associate Professor, 医学部附属病院, 助教授 (60093994)
TERASAKI Hidenori Kumamoto university Medical School Dept. of Anesth. Associate Professor, 医学部, 助教授 (30040562)
|
|---|
| Project Period (FY) |
1990 – 1991
|
| Project Status |
Completed (Fiscal Year 1991)
|
| Budget Amount *help |
¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1991: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥4,900,000 (Direct Cost: ¥4,900,000)
|
|---|
| Keywords | blood gases / artificial lung / intravenous lung assist / hollow fiber lung / respiratory failure / IVOX |
|---|
| Research Abstract |
This project was aimed at the development of a simple and nonivasive artificial lung for intravenous blood gas exchange in patients with respiratory failure.
The lung is made of a bundle of several hundreds of curled hollow-fibers, about 20cm in length. A long oxygen-delivery tube in placed in the center of the bundle. The distal end of the hollow-fibers are opened to a chamber where oxygen is delivered through the central tube. The proximal ends of the hollow fibers are gathered to a gas collecting chamber, which is connected to a suction tube concentrically running outside of the oxygen-delivery tube. Oxygen is delivered to the hollow fibers by negative pressure applied to the suction catheter.
The lung and adjacent part of the tubes are inserted into the vena cava via the right jugular vein or a femoral vein. A vibration pump with a flowmeter and a manometer to measure negative pressure were newly developed to ventilate the hollow-fiber lung by suction. Various sizes of lungs were produced, but miniaturization, without losing gas exchange efficacy, was difficult to attain. Animal experiments show that this lung leaves much to be improved for real safety.
The idea to insert in turn a delivery tube and bundles of hollow fibers into a vein, then compose an artificial lung in the blood vessel, was born. Though it is difficult to realize with the current technolgy, it will become a very useful means of incorporating artificial organs in a blood vessel.
More than 100 patients have undergone IVLA in the U. S. A. and Europe. Thrombosis, hemorrhage, difficult removal of the lung, etc are the problems to be solved. When both extracorporeal and intravenous lung assist are improved, it will be difficult to decide which is more appropriate for patients with mild respiratory failure.
|
