| Project/Area Number |
02454363
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | The Jikei University School of Medicine |
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Principal Investigator |
TANIFUJI Yasumasa The Jikei University School of Medicine, Anesthesiology, Associate Professor, 医学部, 助教授 (00056847)
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| Co-Investigator(Kenkyū-buntansha) |
MIYANO Kazuko The Jikei University School of Medicine, Anesthesiology, Instructor, 医学部, 助手 (90209924)
KAZESHIMA Kazuyuki The Jikei University School of Medicine, Anesthesiology, Instructor, 医学部, 助手 (80185727)
MISHIMA Kimi The Jikei University School of Medicine, Anesthesiology, Instructor, 医学部, 助手 (70181873)
堀口 徹 東京慈恵会医科大学, 医学部, 助手 (60173639)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1992: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | striatum / dopamine / volatile anesthotics / neurotransmitter / MAC / microdialysis / ドパミン / マイクロダイアリシス法 / 揮発性麻酔薬 / マイクロダイアリス法 / 線状体 / ド-パミン / 3.チ-ジヒドロキシフェニル酢酸(DOPAC) / ホモバニリン酸(HVA) |
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| Research Abstract |
The effect of volatile anesthetics on dapaminergic nervous system by in vivo microdialysis.
(1) The effect of halathane dose on dopamine in rat striatum.
(2) Differential effects of four Kinds of volatile anesthetics on dopamine in rat striatum.
(3) The effect of the dopamine content in atriatum on the anesthetic requirement.
(4) The relationship between the changing MAC caused by agingand neurotransmitter, norepirephine, serotonin, and dopamine content in rat brain.
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