Pathophygiological study of choroidal detachment
| Project/Area Number |
02454405
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
DANJO Shinji M. D., Osaka University Medical School. Department of Ophthalmology. Assistant Professor, 医学部, 助手 (80183474)
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| Co-Investigator(Kenkyū-buntansha) |
桑山 泰明 大阪大学, 医学部, 助手 (70186568)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1991: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1990: ¥3,700,000 (Direct Cost: ¥3,700,000)
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| Keywords | Choroidal Detachment / Suprachoroidal Space / Hypotony / Choroidal Inflammation / Choroidal Circulation / Intraocular Circulation |
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| Research Abstract |
The experimental system in established that the hydrostatic pressure of suprachoroidal space can be monitored constantly following implantation silicone sponge with inner cavity in rabbit eyes. Using this system, several factors which relate to the choroidal detachment, were identified, monitoring hydrostatic pressure of suprachoroidal space and intraocular pressure simultaneously.
Results were obtained as follow :
1. In rabbit eyes with normal intraocular pressure without inflammation, the hydrostatic pressure of suprachoroidal space is always lower than intraocular pressure.
2. The decrease or extinguishment of difference between intraocular pressure and hydrostatic pressure of suprachoroidal space, which is considered as the initial stage of choroidal detachment, was observed with rabbit eyes with hypotony. The reverse phenomena, which is hydrostatic pressure of suprachoroidal space becomes higher than intraocular pressure, were observed with long-term hypotony rabbit eyes.
3. In eyes with acute choroiditis by cryo application, same phenomena were observed. Such phenomena occurred more frequently in eyes with acute inflammation and hypotony.
4. In clinical study, the aqueous protein level increased rapidly, before the appearance of choroidal detachment, it decreased after the extinguishment of choroidal detachment.
The intraocular circulation of choroidal detachment in human eyes is very similar with the reverse phenomena in rabbit eyes.
5. In the eye with disturbance of choroidal circulation, such as excessive scleral buckling and destruction of vortex vein, the reverse phenomena may be occurred under the condition of normal or high intraocular pressure.
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Report
(3 results)
Research Products
(15 results)
