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Mechanism of intraocular neovascularization and its regression

Research Project

Project/Area Number 02454411
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionTokyo Women's Medical Collage

Principal Investigator

HORI Sadao  Tokyo Women's Medical Collage Professor, 医学部, 教授 (20143498)

Co-Investigator(Kenkyū-buntansha) KOSEKI Yoshiyuki  Tokyo Women's Medical Collage Assistant, 医学部, 助手 (80215269)
FUNATSU Hideharu  Tokyo Women's Medical Collage Assistant, 医学部, 助手 (50181441)
KITANO Shigehiko  Tokyo Women's Medical Collage Lectureor, 医学部, 講師 (30161483)
KIDOGUCHI Hiroshi  Tokyo Women's Medical Collage Lectureor, 医学部, 講師 (30204936)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1991: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1990: ¥4,600,000 (Direct Cost: ¥4,600,000)
Keywordsintraocular neovascularization / regression / immuno-histochemistry / basic fibroblast growth factor / lysosomal enzyme / laser flare-cell meter / protein concentration / diabetic retinopathy / 免疫組識化学 / 眼内血管新生 / 角膜 / 硝子体 / 前房蛋白濃度 / 組織化学 / 塩基性線維芽細胞成長因子
Research Abstract

Mechanism of intraocular neovascularization and its regression were investigated histochemically and immune-histochemically in the animal models. Intravitreal neovascularization was made in the eyes of monleys and pigmented rabbits by intravitreal implantation of basic fibroblast growth factor(b-FGF). Newly formed vessels were originated from the retina and choaroid in the monkey, and from the choroid in the rabbits.
Corneal neovascularization was made by implantation of b-FGF in the corneal micropockets, and the newly formed vessels invaded from the lifflus towards the center of the cornea. Thelysoscmal enzymes were detected in the initial phase of neovascularization. Fibronectin was activated in the early phase of neovascualrization and vanished in the early phase of regression. Lamirline and type IV collagen were found to surround the new vessels and remained late in the course of regression. Factor VIII was detected on the endothelial cells of new vessels, and showed geographical stains in the regression phase. The protein concentration in the anterior chamber of diabetic patients calicurated by laser flare-cell meter in order to study a relationship between neovascualrization and intraocular leakage of plasma protein.
The protein concentration in the anterior chamber increased as the stage of retinopathy advanced, and also increased after laser phtocoagulation treatment.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report

Research Products

(16 results)

All Other

All Publications (16 results)

  • [Publications] 堀 貞夫: "眼内血管新生の病態" 日本眼科学会誌. 94. 1103-1121 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 堀 貞夫: "眼科領域での最近のレ-ザ-診断と治療" 女子医大誌. 61. 192-196 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 蔵並 貴子,木戸口 裕,北野 滋彦,堀 貞夫: "糖尿病網膜症に対するレ-ザ-フレアセルメ-タ-の臨床的応用ー網膜症重症度と光凝固効果についてー" あたらしい眼科. 7. 155-160 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 蔵並 貴子,木戸口 裕,北野 滋彦,堀 貞夫: "糖尿病網膜症に対する光凝固後早期における房水蛋白濃度の変化ーレ-ザ-フレアセルメ-タ-を用いてー" あたらしい眼科. 7. 161-165 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sadao Hori: "Pathophysiology of intraocular noevascularization." Acta Soc Ophthalmol Jpn. 92(12). 1103-1121 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Sadao Hori: "Update laser diagnosis and treatment in clinical ophthalmology." J Tokyo Women's Med Coll. 61(3). 192-196 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takako Kuranami, Hiroshi Kidoguchi, Shigehiko Kitano, Sadao Hori: "A clinical application of the laser flare-cell meter on the evaluation of diabetic retinopathy." Atarashii Ganka. 7(1). 155-160 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Takako Kuranami, Hiroshi Kidoguchi, Shigehiko Kitano, Sadao Hori: "Early changes in aqueous protein concentration measured by laser flare-cell meter after photocoagulation for diabetic retinopathy." Atarashii Ganka. 7(1). 161-165 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 堀 貞夫: "眼内血管新生の病態" 日本眼科学会誌. 94. 1103-1121 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 堀 貞夫: "眼科領域での最近のレ-ザ-診断書と治療" 女子医大誌. 61. 192-196 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 蔵並 貴子,木戸口 裕,北野 滋彦,堀 貞夫: "糖尿病網膜症に対するレ-ザ-フレアセルメ-タ-の臨床的応用ー網膜症重症度と光凝固効果についてー" あたらしい眼科. 7. 155-160 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 蔵並 貴子,木戸口 裕,北野 滋彦,堀 貞夫: "糖尿病網膜症に対する光凝固後早期における房水蛋白濃度の変化ーレ-ザ-フレアセルメ-タ-を用いてー" あたらしい眼科. 7. 161-165 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 堀 貞夫: "眼内血管新生の病態" 日本眼科学会雑誌. 94. 1103-1121 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 堀 貞夫: "眼科領域での最近のレ-ザ-診断と治療" 東京女子医大誌. 61. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 須藤 史子,北野 滋彦,堀 貞夫: "硝子体新生血管モデルの作成" 日本眼科学会雑誌.

    • Related Report
      1990 Annual Research Report
  • [Publications] 高橋 貴子,木戸口 裕,堀 貞夫: "糖尿病網膜症に対する光凝固長期後の房水蛋白濃度の変化" あたらしい眼科.

    • Related Report
      1990 Annual Research Report

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Published: 1990-03-31   Modified: 2016-04-21  

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