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Mechnism of anti-atherogenic action of Eicosapentaenoic acid(EPA).

Research Project

Project/Area Number 02454505
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionChiba University Medical School

Principal Investigator

TAMURA Yasushi  Chiba Univ. Med. School Asso. Prof., 医学部, 助教授 (90009671)

Co-Investigator(Kenkyū-buntansha) TERANO Takashi  Chiba Univ.Med.School Assistant, 医学部, 助手 (70237006)
HIRAI Aizan  Chiba Univ.Med.School Assistant, 医学部, 助手 (10189813)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1990: ¥4,000,000 (Direct Cost: ¥4,000,000)
KeywordsEicosapentaenoic acid / Cholesterol / Macrophage / Oxidative-LDL / Prostacycline / Lipid peroxides / シクロオキシゲナーゼ / 抗酸化剤 / 動脈硬化 / 多価不飽和脂肪酸 / エイユサペンタエン酸 / 泡沫細胞 / マクロファ-ジ / 抗酸化作用 / 単球 / コレステロ-ルエステル / アセチルLDL / 魚脂
Research Abstract

1)Inhibition of foam cell formation by EPA Accumulation of cholesterol was sigunificantly decreased in EPA-rich peritoneal macrophages obtanined from rats fed with purified EPA-E. In addition receptor numbers of acetylated LDL and PDGF production were decreased in EPA-rich rat pineal macrophages. 2)Suppresion of oxidative modification of EPA-rich rabbit LDL. EPA-rich LDL obtained from rabbits fed with purified EPA-E showed a lesser susceptibility to Ca^<++>-catalysed oxidative modification. 3)Study of the effect of EPA on cells enriched with EPA. EPA suppressed proliferation of cultured rat vascular smooth muscle cell enriched with EPA. DHA had a similar effect, but lesser than EPA. 4)Effect of PGI_2 production in EPA-rich rat vascular smooth muscle cells. Enhanced PGI_2 synthesis was noted in EPA-enriched rat vascular smooth muscle cells. This could be most likely explained by stimulation of cyclooxygenase activity by lipid peroxides derived from EPA.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Saitoh H.,Saeto I.,Changk J.,Taniura Y.& S.Yoshida.: "The ettict of in restin of EPA-E on the slavenzer actinty for a utylcvteal LDL und the production of PDGFin rat peitonal malrophaes" Advrnus.in PGS Txsam LTS. 241-248 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamura Y.,Hirai A.,Terano T.and S.Yoshida: "Clinical and epidemiological studies of W-3PUHA in Japan" Nutritiacl Suppor A in Orsun Failere. 89-95 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Chang k.J.,Saitoh H,Tatsuno J.,Tamura Y.,Yoshida S.: "the effect of EPA on the binding and clearadation of oxidiztd LDL and the production of LTBG LTC_4 and POZ-_2 in rat peritonel macvatinoges" Anwal Reviem of NY.and Saiul. 491-493 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Saito H.,Changk.J.,Tamura Y.and Yoshida S.: "Ingestin of EPA-E renders rabbit LDL IPGC supetihl to G1^<+1>-catalyzed oxidative irodifiatin" Biohem .Biophys.Res.Commun. 175. 61-67 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 田村 泰,平井 愛山,寺野 隆,佐藤 博幸: "EPAの栄養学的及び薬理学的研究その歴史と展望" 現代医療. 24増(1). 755-786 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Terano T.,Saito J.,Siiuua T.,Hirai A.,Tamura Y and Yoshida S.: "Enhanument of PGZ_2 tormation by EPA in caltured ratvasanlav an mocle dles" Oxygen Radinls Elsevier.sviene Phblishers B.V.289-292 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hirai A,Terano T,Tamura Y.: "Current Topics in Nutritin and Direares(Omega-3tatty acids Cpidelaiogical and Climial As peis" GA.Sbiller and J.Scala Alan R.Lis Inc.N.Y., 229-252 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Saitoh H, Saito I, Chang K-J, Tamura Y and Yoishida S.: "The effect of ingestion of EPA-E on the scavenger activity for acetylated LDL and the production of PDGF in rat peritoneal macrophages" Advances in PGs, TXs and LTs. 241-248 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamura Y, Hirai A, Terano T and Yoshida S.: "Clinical and epidemiological studies of omega-3 PUFA in Japan" Nutritional Support in Organ Failure. 491-493 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Chang K-J, Saitoh H, Tatsuno J, Tamura Y and Yoshida S.: "The effect of EPA on the binding and degradation of oxidized LDL and the production of LTB_4, LTC_4 and PDI_2 in rat peritoned macrophages" Annual Review of NY Academy of Science. 491-493 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Saitoh H, Chang K-J, Tamura Y and Yoshida S.: "Ingestion of EPA-E renders rabbit LDL less suspetible to Cu^<++>-catalyzed oxidative modification" Biochem. Biophys. Res. Commun. 175. 61-67 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Saitoh I, Saitoh H, Tamura Y and Yoshida S.: "EPA inhibits cholesterole ester accumulation in rat peritoneal macrophages by decreasing the specific binding sites of acetyl LDL" Clinical Biochem. 25. 351-355 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Terano T, Saitoh J, Shiina T, Hirai A, Tamura Y and Yoshida S.: "Enhancement of PGI_2 formation by EPA in cultured rat vascular smooth muscle cells" Oxygen Radicals. Elsevier. Science Publishers B.V.289-292 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamura Y, Hirai A, Terano T, Saitoh H and Yoshida S.: "Anti-atherogenic and anti-inflammatory action of omega-3 PUFAs" Proceeding of the Adelaides EFA Congress. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamura Y, Hirai A, Terano T, Saitoh H and Yoshida S.: "Anti-atherogenic and anti-thrombotic action of EPA" Proceeding of Symposium of omega-3 Fatty acids Metabolism and Biological Effects. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tamura Y, Hirai A, Terano T, Saitoh H and Yoshida S.: "Anti-atherogenic and anti-thrombotic action of EPA" Proceeding of the 5th Scientific Meeting of the Society for Research on PUFAs. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Saitoh I, Saito H, Tamura Y.&Yoshida S: "EPAinhihits Chokstcroleskl. accumulation in rut peritoreol marropehlc bydertasing thospecitic bindi〓 sites of aukjLDL" Climial Biochem.25. 351-355 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田村 泰、平井 愛山、寺野 隆、斉藤 博幸: "EPAの栄養学的及び薬理学的研究 その歴史と展望" 現代医療. 24(増1). 755-786 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] TeranoT.Saitoh,Shiino T,Hirai A.Tamura Y&Yaoshid S: "Euhmccement of PGI_2 formation by EPA in mltmeal rut vasmlar smooth mocleiclbs" Proueding of Oxyen Radinls Elsevier Sveme Pnblisher B.V.289-292 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tamura Y.Hirai A, Terano T Saitoh&Yoshida S: "Anti-atherogenic and anti-inflamuolong actin of W-3 PUFAS." Vroeeding of the Adelaides EFA Congress. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tamura Y Hiroi A,Terano T Saitoh H and Yoshida S: "Anti-Atherogenic and anti-thrombotlc aitin of EPA" Proeeding M Symposium of w-3 FattY acids Nutabolism and Biolosial Effects. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tamura Y Hirai A,Terano T. Saito H&Yoshida S: "Auti-atherogenic and anti-thrombotic atin of EPA" Proeediny the 5th suientifec Meeting of the Society for Reumch on PUFAs. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Chang Kj,Saitoh H.,Tasuno J.,Tamura Y.,Yoshida S.Ozawa A,Fujita T.: "Effect of EPA on the binding and the drardation of oxidized LDL and the production of LTB_4,LTC_4 and PGE_2 in rat pcritoncal macrophages" Annual.Review of New York acudrmy of Samce. 491-493 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Saitoh H.,Chang KJ.,Tamura y.,Yaoshida S: "Ingestion of EPA ethylester renders rabbit rabbit LDL less susuptible to Cu^<++>ーcatalyzed.ーoxidative modification" Bio chem.Biophys Res.Commun.175(1). 61-67 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 森尾 治之,斉藤 博幸,田村 泰: "多価不飽和脂肪酸と血小板凝集" 治療学. 25(1). 39-43 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 平井 愛山,寺野 隆,斉藤 博幸,田村 泰: "魚食と成人病…疫学的検討" 治療学. 25(1). 28-34 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 斉藤 博幸,田村 泰: "Fishoilの血清脂質低下作用" 循環器科. 29. 379-385 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 田村 泰,平井 愛山,寺野 隆,斉藤 博幸: "《レビュ-:プロスタグランデインとその周辺II》エイユサヘンタエン酸の栄養学的薬理学的研究" 現代医療(増刊号). (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Chang k.J,Saitoh.H,Tamura Y and Yoshida S.: "Effect of EPA on the biuding and deqradation of oxidized LDL and the production of LTB_4,LTC_4 and PGE_2 in vat pertoneal macrophages" Aunals of N.Y.Alademy of Sieuce Atherosclevasis II. 598. 491-493 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Saitoh H,Saitoh I,Chang K.J,Tamura Y and Yoshida S.: "Effect of ingestion of EPAーethylester in the scavpuger activity for acetylated CDL and the production of DGF in rat pentoiceal macrophages" Adrances in PG,TX and LT Research Raveu Press LTD.N.Y.edifed by Samuelsson et al. 21. 241-244 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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