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Pathological analyses of lymphoid malignancies based on immunological and molecular biological characteristics.

Research Project

Project/Area Number 02454516
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionMie University

Principal Investigator

SHIRAKAWA Shigeru  Mie University, Department of Medicine, Professor, 医学部, 教授 (20026850)

Co-Investigator(Kenkyū-buntansha) MIWA Hiroshi  Mie University University Hospital, Assistant, 医学部附属病院, 助手 (00209967)
OHNO Toshiyuki  Mei University, Department of Medicine, Assistant, 医学部, 助手 (50194246)
NISHIKAWA Masakatsu  Mie University, Department of Medicine, Instructor, 医学部, 講師 (30144257)
KITA Kenkichi  Mie University, University Hospital, Instructor, 医学部附属病院, 講師 (90169847)
KOBAYASHI Tohru  Mie University, University Hospital, Instructor, 医学部附属病院, 講師 (00144246)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1991: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordslymphoid malignancy / immunophenotype / immunogenotype / dual genotype / AUL (acute unclassified leukemia) / mature B-cell malignancy / Cmu gene deletion / indolent type / リンパ系腫瘍 / 免疫遺伝子型 / 二重遺伝子型 / 骨髄球系抗原 / B前駆細胞性腫瘍 / 急性分類不能白血病(AUL) / 予後
Research Abstract

(1)immunophenotype and immunogenotype of Immature Lymphoid Malignancy : There was a good correlation between immunogenotype and immunophenotype in mature lymphoid malignancies. but there were some discrepancies between the both types such as dual genotype and genotype-phenotype discordance in immature lymphoid malignancies. From the studies of 295 cases with acute denovo leukemia. in 132 cases with AML some cases of CD19+ and/or CD7+ seemed to be AUL(acute unclassif ied leukemia)considered as a candidate of SCL(stem cel I leukemia). Out of 42 ALLs the CD7+ CD1- CD3- CD4- CD8- My-Ag(myeloid antigen)+ cases. considered as those of T-precursor ALLS, and the HLA-DR+ CD19+ CD2O- My-Ag+ ALL, considered as those of B-precursor ALLS. were thought to be a candidate of SCL. The cases with dual genotype were not thought to be SCL. since dual genotype could not be as signs of ability to differentiate to multilineage but as products of the process of active V-DJ rearrangement of Ig heavy chain gene … More .
(2)Differentiation of Mature B-cell Malignancy and Pathological State : CD5 positive B-cells are thought to compose a chief population of foetal B-cells, and primary follicle and locate mainly in mantle zone. CD5 expression is commonly observed on B-CLL. ILL(intermediate lymphocytic lymphoma)and. related disorders, and is suggestive of their early B-cell brigin. Most of HCL(hairy cell leukemia)are)gG type and CD11c positive after completion of Ig class switch. In 45 cases of mature B-cell malignancies the relation between pathological state and Ig class switch was examined in terms of CD5 and CD11c expression and Cmu gene deletion considered as an initial event of Ig class switch. Cmu gene deletion was observed about 80% CD11c positive cases in CD5 positive mature B-cell malignancies. One third of malignant lymphoma with characters of secondary follicle had Cmu gene deletion. but those were both CD5 and CD11c negative. Thus the class switch. by genomic deletion may occur prior to differentiating into follicular center cells, probably at mantle zone B-cell I stage. and there may be plural pathways in differentiation of CD5(+)B-cell toward follicular center cells or plasma cells, suggesting of at least two different clinical types of acute and chronic(indolent)forms in mature B-cell malignancy. Less

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (112 results)

All Other

All Publications (112 results)

  • [Publications] 白川 茂: "臨床医学の展望ー診断および治療上の進歩(3) 血液病学" 日本医事新報. No.3486. 3-11 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 白川 茂,他: "悪性リンパ腫の治療指針" Cuurent Therapy. 9. 276-282 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 白川 茂,他: "薬物とその使い方'91 悪性リンパ腫" 診断と治療. 79. 1229-1239 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 川上 恵基,他: "表現型,遺伝子型からみた“多潜能幹細胞性白血病"の診断" 臨床血液. 32. 618-622 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 白川 茂,他: "悪性リンパ腫のサルベ-ジ療法ー大細胞型リンパ腫を中心に" 血液・腫瘍科. 22. 55-63 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 白川 茂,他: "ホジキン病の診断と治療の実際" 臨床成人病. 21. 1109-1116 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 白川 茂: "悪性リンパ腫の免疫学的分類と治療" リンパ等. 14. 78-79 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 白川 茂,他: "主要疾患ー診断・治療の進歩と予後の変貌 悪性リンパ腫" 診断と治療. 79. 2033-2039 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 三輪 啓志,他: "白血病およびリンパ腫におけるDNA診断" 臨床病理. 39. 1072-1078 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 白川 茂,他: "特集 接着分子とその臨床的意義 造血器腫瘍と接着分子発現" 最新医学. 46. 2407-2416 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Katayama N,et al: "A role of calmodulin in the growth of human haematopoietic progenitor cells." Blood. 75. 1446-1454 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohno R,et al: "Effect of granulocyte colony-stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia" N Engl J Med. 323. 571-577 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ezaki K,et al: "A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia-lymphoma" Cancer. 68. 695-698 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Komado F,et al: "Expression of three major protein kinase C isozymes in various types of human leukemic cells." Cancer Res. 51. 4271-4278 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kawakami K,et al: "Rearrangement patterns of immunoglobulin heavy chain (IgM) and lihgt chain genes in acute lymphoblastic leukemia and chronic myelocytic leukemia lymphoid crisis showing oligoclonal IgH gene rearrangements" Int J Haematol. 55. 61-69 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 北 堅吉,他: "急性未分化細胞白血病(AUL)における免疫遺伝子再構成ーその診断的意義ー" 癌と化学療法. 18. 1084-1089 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 北 堅吉,他: "リンパ球系腫瘍と免疫系遺伝子" 医学のあゆみ. 158. 285-289 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 西井 一浩,他: "遺伝子診断" 内科. 68. 236-240 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tokunaga M,et al: "Biclonality of co posite B-and T-cell lymphomas.A case report" Acta Pathol Jap. 40. 522-530 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Asou H,et al: "Establishment of a human acute myeloid leukemia cell line (Kasumi-I) with 8;21 chromosome translocation" Blood. 77. 2031-2036 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakase K,et al: "Diagnositc and clinical importance of interleukin-2 receptor alpha chain expression on non-T-cell acute leukemia cells." Br.J.Haematol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishii K,et al: "c-kit gene expression in CD7-positive acute lymphoblastic leukemia:A close correlation with expression of myeloid associated antigen CD13" Leukemia.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kita K,et al: "Phenotypical characteristics of acute myelocytic leukemia associated with t(8;21)(q22;q22) chromosomal abnormality:frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kita K,et al: "A granulocytic poputation with the monoclonally rearranged immunoglobulin heavy chain genes in mixed crisis of chronic myelocytic leukemia and philadelphia chromosome-positive acute leukemia"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kita K,et al: "A close correlation between CD11c expression and immunoglobulin Cμ gene deletion in CD5(+) chronic lynphocytic leulcemia"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shimizu N,et al: "“Granulopoiesis in a MDS patient with monosomy 7:probable derication of granulocytes not from G-CSF but IL-3 and GM-CSF dependent progenitors."in “Myelodysplastic Syndrome and Cytokines" eds by Miyazaki T,et al" Elsevier Science Publishers, 145-148 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 北 堅吉,白川 茂: "造血器腫瘍の分子生物学I.リンパ系腫瘍の遺伝子診断 分子血液学新版 日本血液学全書別巻(日本血液学全書刊行委員会編)" 丸善, 129-137 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa. S: "Review of clinical medicine : Hematology" Nippon Izi Shinpo. No3486. 3-11 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa. S, et al: "Therapeutic Principle of malignant lymphoma" Current Therapy. 9. 276-282 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa. S, et al: "Prug and Usage'91 : Malignant lymphoma" Shindan to Chiryo. 79. 1229-1239 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kawakita. K, et al: "Diagnosis of stem cell leukemias in view of phenotype and genotypic analysis" Rhinsho Ketsueki. 32. 618-622 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa. S, et al: "Salvage therapy with special reference to large cell lymphoma" Ketsueki Shuyoka. 22. 55-63 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa. S, et al: "Practical diagnosis and therapy of Hodgkin's disease" Rhinsho Seijinbyo. 21. 1109-1116 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa. S: "Immunological classification and therapy" Lymphology. 14. 78-79 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa. S, et al: "Main diseases-Progross in diognosis and therapy and change in prognosis" Shindan to Chiryo. 79. 2033-2039 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Miwa. H, Eet al: "DNA diagnosis in leukemia and lymphoma" Rhinsho Byori. 39. 1072-1078 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shirakawa. S, et al: "Adhesion molecule and clinical significance : Hemopoietic malignancy and expression of adhesion molecule" Saishin Igaku. 46. 2407-2416 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Katayama. N, et al: "Arale of calmodulin in the growth of human haematopoietic progenitor cells" Blood. 75. 1446-1454 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ohno. R, et al: "Effect of granulocyte colony-stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia" N Engl J Med. 323. 571-577 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Ezaki. K, et al: "A combination trial of human lymphoblastoid interferon and bestrabucil(KM2210)for adult T-cell leukemia-lymphoma" Cancer. 68. 695-698 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Komada. F, et al: "Expression of three major protein kinase Cisozymes in various types of human leukimic cells" Canser Res. 51. 4271-4278 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kawakita. K, et al: "Rearrangement patterns of immunoglobulin heavy chain(IgM) and light chain genes in acute lymphoblastic leukemia and chronic myelocytic leukemia lymphoid crisis showing oligoclonal IgH gene rearrangements" Int J Haematol. 55. 61-69 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kita. K, et al: "Immune gene rearrangement in acute undifferntiated leukemia(AUL)-Its diagnostic significance" Gan to Kagakuryoho. 18. 1084-1089 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kita. T, et al: "Lymphoid malignancy and immune gene" Igaku no Ayumi. 158. 285-289 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishii. K, et al: "Gene diagnosis" Naika. 68. 236-240 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tokunaga. M, et al: "Biclonality of co posite B-and T-cell lymphomas. A case report" Acta Pathol Jap. 40. 522-530 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Asou H, et al: "Eatablishment of a human acute myeloid leukemia cell line(Kasumi-l) with 8i21 chromosome translocation" Blood. 77. 2031-2036 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nakase. K, et al: "Diagnostic and clinical important of interleukin-2 receptor alpha chain expression on non-T-cell acute leukemia cells" Br. J. Haematol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Nishii. K, et al: "c-kit gene expression in CD7-positive acute lymphoblastic leukemia : A close correlation with expression of myeloid associated antigen CD13" Leukemia.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kita. K, et al: "Phenotypical characteristics of acute myelocytic leukemia associated with t(8i21) (q22iq22)chromosomal abnormality : frequent expression of immature B-cell antiger CD19 together with stem cell antiger CD34" Blood.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kita. K, et al: "A granulacytic poputation with the monoclonally rearranged immuna globulin heavy chain genes in mixed crisis of chronic myelocytic leukemia and philadelphia chromosome positive acute leukemia"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kita. K, et al: "A close correlation between CD11c expression and immunoglobulin Cmu gene deletion in CD5(+)chronic lymphocytic leukemia"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shimizu. N, et al: "Granulopoiesis in a MDS patient with monosomy 7 : probable derication of granulocytes not from G-CSF but IL-3 and GM-CFS dependent progenitors "in Myelodysplastic Syndrome and Cytokines" eds by Miyazaki T, et al" Elsevier Science Publishers. 145-148 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kita. K, Shirakawa. S: "Molecular biology I. Gene diagnosis of lymphoid malignancy Molecular Hematology New Edition of Nippon Ketsuekigaku Zensyu" MaruzenK. 129-137 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 白川 茂: "臨床医学の展望ー診断および治療上の進歩(3) 血液病学" 日本医事新報. No.3486. 3-11 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 白川 茂,他: "悪性リンパ腫の治療指針" Cuurent Therapy. 9. 276-282 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 白川 茂,他: "薬物とその使い方 '91 悪性リンパ腫" 診断と治療. 79. 1229-1239 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 川上 恵基,他: "表現型,遺伝子型からみた“多潜能幹細胞性白血病"の診断" 臨床血液. 32. 618-622 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 白川 茂,他: "悪性リンパ腫のサルベ-ジ療法ー大細胞型リンパ腫を中心に" 血液・腫瘍科. 22. 55-63 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 白川 茂,他: "ホジキン病の診断と治療の実際" 臨床成人病. 21. 1109-1116 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 白川 茂: "悪性リンパ腫の免疫学的分類と治療" リンパ学. 14. 78-79 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 白川 茂,他: "主要疾患ー診断・治療の進歩と予後の変貌 悪性リンパ腫" 診断と治療. 79. 2033-2039 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 三輪 啓志,他: "白血病およびリンパ腫におけるDNA診断" 臨床病理. 39. 1072-1078 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 白川 茂,他: "時集 接着分子とその臨床的意義 造血器腫瘍と接着分子発現" 最新医学. 46. 2407-2416 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Katayama N,et al: "A role of calmodulin in the growth of human haematopoietic progenitor cells" Blood. 75. 1446-1454 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ohno R,et al: "Effect of granulccyte colonyーstimulating factor after intensive induction therapy in relapsed or refractory acute leukemia" N Engl J Med. 323. 571-577 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ezaki K,et al: "A combination trial of human lymphoblastoid interferon and bestiabucil(KM2210)for adult Tーcell leukemiaーlymphoma" Cancer. 68. 695-698 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Komada F,et al: "Expression of three major protein kinase C isozymes in various types of human leukemic cells." Cancer Res. 51. 4271-4278 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kawakami K,et al: "rearrangement pattems of immunoglobulin heavy chain(IgM)and light chain genes in acute lymphoblastic leukemia and chronic myelocytic leukemia lymphoid crisis showing oligoclonal IgH gene riarrangements." Int J Haematol. 55. 61-69 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 北 堅吉,他: "急性未分化細胞白血病(AUL)における免疫遺伝子再構成ーその診断的意義ー" 癌と化学療法. 18. 1084-1089 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 北 堅吉,他: "リンパ球系腫瘍と免疫系遺伝子" 医学のあゆみ. 158. 285-289 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西井 一浩,他: "遺伝子診断" 内科. 68. 236-240 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tokunaga M,et al: "Biclonality of co posite Bーand TーCell lymphomas.A case report" Acta Pathol Jap. 40. 522-530 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Asou H,et al: "establishment of a human acute myeloid leukemia cell line(Kasumiー1)with 8;21chromosome translocation" Blood. 77. 2031-2036 (1991)

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      1991 Annual Research Report
  • [Publications] Nakase K,et al: "Diagnostic and clinical importance of interleukinー2 receptor alpha chain expression on nonーTーcell acute leukemia cells" Br .J.Haematol.

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      1991 Annual Research Report
  • [Publications] Nishi K,et al: "Cーkit gene expression in CD7ーpositive acute lymphoblastic leukemia:A closイ correlation with expression of myeloid associated artigen CD13." Leukemia.

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      1991 Annual Research Report
  • [Publications] Kita K,et al: "Phenotypical characteristics of acute myelocytic leukemig associoteシ with t(S;21)(g22;g22)chromosomal abnormality;freguent expression of immature Bーcell antigen CD19 together with stem cell antigen CD34."

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      1991 Annual Research Report
  • [Publications] Kita K,et al: "A granulocytic poputation with the monoclonally rearranged immunaglobulin neavy chain genes in mixed crisis of chronic myelocytic leukemia and philadelphia chromosome positive acute leukemia"

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      1991 Annual Research Report
  • [Publications] Kiat K,et al: "A close correlation between CD11c expression and immunoglobulin Cμ gene deletion in CD5(+)chronic lymphocytic leukemia."

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      1991 Annual Research Report
  • [Publications] Shimizu N,et al: "“Granulopoiesis in a MDS patient with monosomy 7:probable derication of granulocytes not from GーCSF but ILー3 and GMーCSF dependent prugenitors." in “Myelodysplastic Syindrome and Cytokines"esd by Miyazaki T,et al" Elsevier science Publishers, 145-148 (1991)

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      1991 Annual Research Report
  • [Publications] 北 堅吉,白川 茂: "造血器腫瘍の分子生物学 1.リンパ系腫瘍の遺伝子診断 分子血液学新版日本血液学全書別巻(日本血液学全書刊行委員会編)" 丸善, 129-137 (1990)

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      1991 Annual Research Report
  • [Publications] Nosaka T,et al: "Crossーlineage gene rearrangements in human Ieukemic Bーprecursor cells occur frequently with VーDJ rearrangements of IgH genes." Blood. 74. 361-368 (1989)

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      1990 Annual Research Report
  • [Publications] Shirakawa S,et al: "Symposium II Molecular genetics and its clinical application in hematopoietic malignancies:Introductory remarks." Acta Haematol Jpn. 52. 1412-1413 (1989)

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      1990 Annual Research Report
  • [Publications] Miwa H,et al: "A mechanism for crossーlineage gene rearrangements in Bーcell neoplasm." Acta Haematol Jpn. 52. 1442-1450 (1989)

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      1990 Annual Research Report
  • [Publications] Ikeda T,et al: "A case of chronic myelocytic leukemia in blast crisis:The myeloblasts became overt from lymphoid and myeloid mixed population of the blast crisis cells after chemotherapy." Acta Haematol Jpn. 53. 62-69 (1990)

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      1990 Annual Research Report
  • [Publications] Ikeda T,et al: "Genetic heterogeneity in blast crisis of chronic myelocytic leukemia." Leukemia Res. 14. 195-201 (1990)

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      1990 Annual Research Report
  • [Publications] Ikeda T,et al: "Oligoclonal immunoglobulin gene rearrangements in Philadelphia chromosomeーpositive common acute lymphoblastic leukemia." Jpn J Cancer Res. 81. 340-344 (1990)

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      1990 Annual Research Report
  • [Publications] 白川 茂,他: "シンポジウム2各領域の癌治療における最近の動向と他領域癌臨床への情報ーその2ー 5)悪性リンパ腫" 日本癌治療学会誌. 24. 678-681 (1989)

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      1990 Annual Research Report
  • [Publications] 白川 茂,他: "各種疾患の腫瘍マ-カ- リンパ系悪性腫瘍" 診断と治療. 73. 547-553 (1989)

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      1990 Annual Research Report
  • [Publications] 白川 茂,他: "造血器腫瘍の治療 最近の進歩 急性リンパ性白血病(ALL)" 日本内科学会雑誌. 78. 769-773 (1989)

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      1990 Annual Research Report
  • [Publications] 白川 茂,他: "Bリンパ腫の病態・治療と予後因子" 病理と臨床. 7. 965-975 (1989)

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  • [Publications] 白川 茂,難波 紘二: "シンポジウムII 悪性リンパ腫における分子遺伝学的アプロ-チ司会のことば" 日本網内系学会雑誌. 29. 109-200 (1989)

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  • [Publications] 三輪 啓志,他: "シンポジウムIIー2 悪性リンパ腫診断における分子遺伝学的手法の有用性と限界" 日本網内系学会雑誌. 29. 127-135 (1989)

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      1990 Annual Research Report
  • [Publications] 白川 茂,他: "消化器癌の全身的な化学療法の実際(6)消化管の悪性リンパ腫" 臨牀消化器内科. 4. 1967-1976 (1989)

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      1990 Annual Research Report
  • [Publications] 白川 茂,他: "悪性リンパ腫治療ー最近の動向" 臨床科学. 25. 1293-1306 (1989)

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  • [Publications] 大野 敏之,他: "悪性リンパ腫の表現型と遺伝子型" 臨床科学. 25. 1371-1377 (1989)

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      1990 Annual Research Report
  • [Publications] 白川 茂: "内科診療の進歩 悪性リンパ腫 診断と治療" 日本内科学会雑誌. 78. 1550-1554 (1989)

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  • [Publications] 白川 茂: "白血病と血球分化1.総論" Biomedicine. 5. 340-341 (1990)

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  • [Publications] 白川 茂,他: "老年者の白血病" 老化と疾患. 3. 592-600 (1990)

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  • [Publications] 北 堅吉,他: "悪性組織球症,悪性細網症ー臨床的診断と組織学的診断の異同について" 日本網内系学会雑誌. 30. 287-291 (1990)

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  • [Publications] 白川 茂,小林 透: "悪性リンパ腫の治療方針" 医学のあゆみ. 152. 947-954 (1990)

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  • [Publications] 白川 茂: "第1回日本内科学会生涯教育講演会BセッションIV血液・腫瘍2.白血病・悪性腫瘍" 日本内科学会雑誌. 79. 400-404 (1990)

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  • [Publications] 白川 茂,他: "Up Date注目されている話題の疾患のすべて 悪性リンパ腫" 現代医療. 22. 1929-1934 (1990)

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  • [Publications] 小林 透,他: "本邦における慢性リンパ性白血病の特性" 臨床血液. 31. 554-563 (1990)

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  • [Publications] 白川 茂: "造血器腫瘍 診断法の進歩" 現代医療. 22(増III). 363-368 (1990)

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  • [Publications] 白川 茂: "90年代の病理に託してー分子病理学" 病理と臨床. 8. 566-567 (1990)

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  • [Publications] 白川 茂,他: "悪性リンパ腫の治療ー最近の進歩 化学療法の最近の動向" 血液・腫瘍科. 21. 424-433 (1990)

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  • [Publications] 白川 茂,他: "最新の白血病治療の現況と課題(2)急性リンパ性白血病" 臨牀看護. 17. 46-51 (1991)

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  • [Publications] Kita K,et al(eds by Hanaoka M et al.): "“Molecular genetic analysis of lymphoid malignancies"In “Lymphoid malignancies;Immunocytology and Cytogenetics"" Friend and Wood,Philadelphia, 3-13 (1990)

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      1990 Annual Research Report
  • [Publications] 北 堅吉,白川 茂: "「リンパ系腫瘍の遺伝子診断」新版日本血液学全書別巻「分子血液学」新版日血全書刊行委員会編" 丸善, 129-137 (1990)

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  • [Publications] 白川 茂: "「悪性リンパ腫」「臨床看護事典」高久史磨監修" メヂカルフレンド社, 1-3 (1990)

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  • [Publications] 斉藤達雄監修,小林透,白川茂: "「非ホジキンリンパ腫」多剤併用療法を主とするチャ-ト式癌化学療法" メディカルレビュ-社, 85-93 (1990)

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Published: 1991-04-01   Modified: 2016-04-21  

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