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Marine adhesive proteins as new bioadhesive materials

Research Project

Project/Area Number 02455012
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionShinshu University

Principal Investigator

YAMAMOTO Hiroyuki  Shinshu University, Faculty of Textile Science and Technology, Associate professor, 繊維学部, 助教授 (60021151)

Co-Investigator(Kenkyū-buntansha) INOUYE Katuhiko  Shinshu University, Faculty of Textile Science and Technology, Assistant, 繊維学部, 助手 (30092860)
Project Period (FY) 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1990: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsMarine adhesive proteins / Synthesis of adhesive proteins / Bioadhesives / Water insolubilization / Cross-linking and gelation / Bonding characteristics / Wettability of adhesive proteins / New material science / 接着タンパク質の表面化学 / アコヤ貝の接着タンパク質 / アミノ酸組成、配列 / 接着タンパク質の合成 / 不溶化、ゲル化反応 / アミノ酸組成・配列 / モデルタンパク質合成 / 海洋無脊椎動物 / 材料開発化学
Research Abstract

The adhesive proteins secreted from the marine invertebrates such as barnacles and mussels are promise as bioadhesive and are expected to increase further basic and applied materials science research. The results obtained in this project are summarized as below
1. Many kinds of marine adhesive proteins such as mussels and model proteins were synthesized by the organic and polymer chemical syntheses.
2. Cross-linking and insolubilization reactions were investigated using enzymes and organic cross-linking agents. When small amount of cross-linking agents were used, soft swelling gels were prepared. The soft gels can be used as biohydrogels such as artificial skin, and adsorpted selectively acidic amino acids in the gel matrix.
3. Wettability of the adhesive proteins and nodel proteins were studied on the substrate surfaces in order to evaluate the basic surface physicochemical characteristics.
4. Bonding strengths as bioadhesives were examined thoroughly using a variety of substrates such as metals, woods, plastics, stones, and biomaterials (bones and skins).
5. Briefly summarizing, polymer chemical approarches as principal steps to the marine adhesive proteins has mostly finished. However, physicochemical investigations are still ongoing.
6. In future, biological studies both in vitro and in vivo are necessary in order to use practically the adhesive proteins as bioadhesives.
7. Within up to date investigation, the marine adhesive proteins are promise materials as bioadhesives and are sure to add some new knowledge in bioadhesion field.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] H.Yamamoto et al: "Cross-linking and gel formation of water-soluble lysine polypeptides.An insolubilization model reaction for adhesive proteins" Int.J.Biol.Macromol.14. 66-72 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 山本 浩之: "天然接夜剤の現状と将来" 日本接着学会誌. 28. 191-198 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 山本 浩之ら: "生物の接着" 比較生理生化学. 9. 118-128 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto et al: "Synthesis of adhesive protein from the vitellaria of the liver fluke Fasciola hepatica" Amino Acids.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto et al: "Works of adhesion of synthetic polypeptides containing L-lysine" J.Colloid Interface Sci.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto et al: "Synthesis and bonding studies of adhesive proteins of Chilean mussel Aulacomya ater" Biomimetics.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Research Trends Pub" Trends in Polymer Science. 1. 123 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Insolubilizing and adhesive studies of water-soluble synthetic model polypeptides" Int. J. Biol. Macromol.12. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Bio- and natural adhesives" Adhesion Soc. Jpn. Techno-Trends. 139. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Sessile mechanism of marine animals (Kaisan seibutu no huchaku kikou)" Kouseisha Kouseikaku. 214 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Bioadhesives" New Materials (Shin-sozai). 2. 52 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Study on the adhesive protein of the pearl oyster" J. Adhesion Soc. Jpn.27. 55 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Synthesis of marine adhesive proteins secreted from Chilean mussel" Koubunshi ronbunshu. 48. 257 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Bio- and natural adhesives 2" Adhesion Soc. Jpn. Techno-Trends. 126 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Synthesis and conformational study of cuticle collagen models and the application as bioadhesive formulation" J. Material Chem.1991. 947 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Polypeptide models of the arthropodin protein of the barnacle Balanus balanoides" Marine Chem.37. 131 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Cross-linking and, gel formation of water-soluble lysine polypeptides. An insolubilization model reaction for adhesive proteins" Int. J. Biol. Macromol.14. 66 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Perspective for natural adhesives from renewable resources" J. Adhesion Soc. Jpn.28. 191 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Bio- and natural adhesives 3" Adhesion Soc. Jpn. Techno-Trends. 50 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Biological adhesion" Comparative Phys. Biochem. (Hikaku Seiri Seikagaku). 9. 118 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Synthesis of adhesive protein from the vitellaria of the liver fluke Fasciola hepatica" Amino Acids.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Study on the adhesive protein of the pearl oyster. Part 2" Marine Fouling (huchaku seibutu kenkyu).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Works of adhesion of synthetic polypeptides containing L-lysine" J. Colloid Interface Sci.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Synthesis and bonding studies of adhesive proteins of Chilean mussel Aulocomya ater" Biomimetics.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto: "Works of adhesion of the adhesive proteins in aqueous solution on the various solid surfaces" J. Adhesion Soc. Jpn.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Yamamoto et al: "Cross-linking and gel formation of water-soluble lysine polypeptides.An insolubilization model reaction for adhesive proteins" Int.J.Biol.Macromol.14. 66-72 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山本 浩之: "天然接着剤の現状と将来" 日本接着学会誌. 28. 191-198 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山本 浩之ら: "生物の接着" 比較生理生化学. 9. 118-128 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Yamamoto et al: "Synthesis of adhesive protein from the vitellaria of the liver fluke Fasciola hepatica" Amino Aceds.

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Yamamoto et al: "Works of adhesion of synthetic polypeptides containing L-lysine" J.Colloid Interface Sci.

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Yamamoto et al: "Synthesis and bonding studies of adhesive proteins of Chilean mussel Aulacomya ater" Biomimetics.

    • Related Report
      1992 Annual Research Report
  • [Publications] 山本 浩之ら: "アコヤ貝の接着タンパク質に関する研究" 日本接着学会誌. 27. 55-58 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 山本 浩之ら: "チリ産い貝に由来する接着タンパク質の合成" 高分子論文集. 48. 257-259 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Yamamoto et al: "Synthesis and conformational study of cuticle collagen models and the application as bioadhesive formulation" J.Materials Chemistry. 1991. 947-954 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Yamamoto et al: "Photoresponsive peptide and polypeptide systems,part 11.Photochromism of poly(Lーornithine)containing various azoーcontents in side chains" Polmyer International.

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Yamamoto et al: "Studies of marine adhesive proteins.Polypeptide models of barnacle Balanus balanoides arthropodin protein" Marine Chemistry.

    • Related Report
      1991 Annual Research Report
  • [Publications] 山本 浩之: "バイオ、天然物接着剤(2)" 日本接着学会テクノトレンド90資料集. 45-82 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 山本 浩之(分担共著): "海産生物の付着機構" 恒星社厚生閣, 214 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] H.Yamamoto,et al: "Photoresponsive peptide and polypeptide systems:Part 9.Synthesis and reversible photochromism of azo aromatic poly(α,γーLーdiaminobutyric acid)" Polymer International. 24. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Yamamoto,et al: "Photoresponsive peptide and polypeptide systems:10.Synthesis and reversible photochromism of azo aromatic poly(α,βーdiaminopropionic acid)" Int.J.Biol.Macromol.12. 257-262 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Yamamoto,et al: "Insolubilizing and adhesive studies of waterーsoluble synthetic model polypeptides" Int.J.Biol.Macromol.12. 305-310 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山本 浩之: "バイオ接着剤" 新素材. 2. 52-56 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山本 浩之: "バイオ・天然物接着剤" 日本接着学会テクノトレンド89 資料集. 139-165 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Yamamoto,et al: "Trens in Polymer Science I" Research Trends (India),

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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