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Adipocyte forming activity and its regulation, which affect obesity development.

Research Project

Project/Area Number 02556017
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 製造化学・食品
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SUGIMOTO Etsuro  Kyoto University Professor, 農学部, 教授 (50026522)

Co-Investigator(Kenkyū-buntansha) INOUE Kazuo  Kyoto University Instructor, 農学部, 助手 (80213148)
KAWADA Teruo  Kyoto University Instructor, 農学部, 助手 (10177701)
FUSHIKI Tohru  Kyoto University Associate Professor, 農学部, 助教授 (20135544)
樋口 雅子  京都大学, 農学部, 教務職員 (40110762)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 1992: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1991: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1990: ¥8,000,000 (Direct Cost: ¥8,000,000)
KeywordsObesity / Energy intake / Diet / Food intake / Adipocyte / Adipose tissue / Body fat / Preadipocyte growth factor / 前駆脂肪細胞 / 増殖因子 / 細胞分化 / 細胞増殖 / カロテノイド / 脂溶性ビタミン
Research Abstract

Obesity of abnormal adipose tissue development, is a highly complex phenomenon regulated by many factors. Several recent studies suggested that the number of adipocytes may increase even in adults. From these results, it has been speculated that unknown factors which regulate adipose tissue development forming obesity are present in adipose tissue. Therefore, we investigated the mechanism controlling proliferation of preadipocytes using 3T3-L1, established form Swiss mouse embryos, and Ob1771, established from the epididymal fat pads of genetic obese mouse, cell lines as models of preadipocytes in completely defined serum free medium establised by us. We found the presence of a protein growth factor (M.W.25,000) IN rat adipose tissue which specifically permits the proliferation of preadipocytes. This protein factor appears to function in response to energy intake. Thus preadipocyte growth factor in adipose tissue may play a key role in the controlled system and contribute to the development of adipose tissue.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Teruo KAWADA,: "Proliferation of 3T3-L1 preadipocytes in a completely defined serum-free medium." Cell Biol.Int.Rep.,. 14. 567-574 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Teruo KAWADA,: "Comparative investigation of vitamins and their analogues on terminal differentiation, from Preadipocytes to adipocytes, of 3T3-L1 cells." Comp.Biochem.Physiol.,. 96A. 323-326 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naohito AOKI,: "Protein factor obtained from rat adipose tissue specifically permits the proliferation of the 3T3-L1 and Ob1771 cell lines." Biochem.Biophys.Res.Commun.,. 171. 905-912 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naohito AOKI,: "Preadipocyte growth-promoting activity in adipose tissue of various mammalia." Agric.Biol.Chem.,. 55. 2409-2411 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Reiko KAWAI,: "Involvement of phosphoinositol-glycan induction of diffrentiation,from preadipocytes to adipocytes,of 3T3-L1 cells by insulin-like growth factor I." Agric.Biol.Chem.,. 55. 2801-2806 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yasutomi KAMEI,: "Lipoprotein lipase enzyme expression in 3T3-L1 adipocytes is posttranscriptionally down-regulated by retinoic acid." Biochem.Int.,. 26. 923-934 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naohito AOKI,: "Level of preadipocyte growth factor in rat adipose tissue which specifically permits the proliferation of preadipocytes is affected by restricted energy intake." Obesity Res.,. 1. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Teruo Kawada: "Proliferation of 3T3-L1 preadipocytes in a completely defined serum-free medium." Cell biol.Int.Rep.Vol.14, No.6. 567-574 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Teruo Kawada: "Comparative investigation of vitamins and their analogues on terminal differentiation, from preadipocytes to adipocytes, of 3T3-L1 cells." Comp.Biochem.Physiol.Vol.96A, No.2. 323-326 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naohito Aoki: "Protein factor obtained from rat adipose tissue specifically permits the proliferation of the 3T3-L1 and Ob1771 cell lines." Biochem. Biophys.Res. Commun.Vol.171, No.2. 905-912 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naohito Aoki: "Preadipocyte growth-promoting activity in adipose tissue of various mammalia." Agric.Biol.Chem.Vol.55, No.9. 2409-2411 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Reiko Kawai: "Involvement of phosphoinositol-glycan induction of differentiation, from preadipocytes to adipocytes, of 3T3-L1 cells by insulin-like growth factor I." Agric.Biol.Chem.Vol.55, No.11. 2801-2806 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yasutomi Kamei: "Lipoprotein lipase enzyme expression in 3T3-L1 adipocytes is posttranscriptionally down-regulated by retinoic acid." Biochem.Int.Vol.26, No.5. 923-934 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naohito Aoki: "Level of preadipocyte growth factor in rat adipose tissue which specifically permits the proliferation of preadipocytes is affected by restricted energy intake." Obesity Res.Vol.1, No.2. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yasutomi Kamei,: "Lipoprotein lipase enzyme expression in 3T3-L1 adipocytes is posttranscriptionally down-regulated by retinoic acid." Biochem.Int.,. 26. 923-934 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Naohito Aoki,: "Level of preadipocyte growth factor in rat adipose tissue which specifically permits the proliferation of preadipocytes is affected by restricted energy intake." Obesity Res.,. 1. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Tawada: "Proliferation of 3T3-L1 preadipocytes in a completely defimed serum free medium。" Cell Biol.Int.Rep.14. 567-574 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Tawada: "Comparative investigation of vitamins and their analogues on terminal differentiation,from pheadipocutes to adipocytes,of 3T3-L1 cells." Comp.Biochem.Physiol.96A. 323-326 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] N.Aoki: "Protein factor obtained from rat adipose tissue specifically permits the prolifetarion of the 3T3-L1 and Ob1771 cell lines." Biochem.Biophys.Res.Commun.171. 905-912 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Kawada: "Intake of sweetner and pungent ingradients increases the thermogenin content in brown adipose tissue of rat." J.Agric.Food.Chem.39. 651-654 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] N.Aoki: "Preadipocyte growth-promoting activity in adipose tissue of various mammalia." Agric.Biol.Chem.55. 2409-2411 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] R.Kawai: "Involvment of phosphoinositol-glycan in induction of differentiation,from preadipocytes to adipocytes,3T3-L1 cells by insulin-like growth factor I." Agric.Biol.Chem.55. 2801-2806 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Kawada: "Obesity:Dietary factors and control" Japan Sci.Soc Press/S.Karger., 272 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Kawada: "Proliferation of 3T3ーLl preadipocytes in a completely defined serumーfree medium." Cell Biol.Internatl.Rep.14. 567-574 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Kawada: "Comparative investigation of vitamins and their analogues on terminal differentiation,from preadipocytes to adipocytes,of 3T3ーLl cells." Comp.Biochem.Physiol.96A. 323-326 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] N.Aoki: "Protein factor obtained from rat adipose tissue specifically permits the proliferation of the 3T3ーLl and Ob 1771 cell lines." Biochem.Biophys.Res.Commun.171. 905-912 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Kawada: "Intake of sweetners and pungent ingredients increases thermogenic content in brown adipose tissue of rat." J.Agric.Food Chem.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] N.Aoki: "Preadipocyte growthーpromoting activity in adipose tissue of various mammalia."

    • Related Report
      1990 Annual Research Report
  • [Publications] N.Aoki: "Level of preadipocyte growth factor in rat adipose tissue which specifically permits the proliferation of preadipocytes is affected by restricted energy intake and fasting."

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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