| Project/Area Number |
02557043
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | National Cardiovascular Center |
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Principal Investigator |
MATSUDA Takehisa Natl. Cardiovasc. Ctr. Res. Inst., Head of the Dept. of Bioengineering, 生体工学部, 部長 (60142189)
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| Co-Investigator(Kenkyū-buntansha) |
YODA Ryuichiro Nippon Leon Co., Ltd. Cteneral Manager of Biological Science Inst., 医療技術研究所・グループ, リーダ
KAMIYA Tetsuo Natl. Cardiovasc. Ctr. Pediatrics Dept., 小児科, 部長
KISHIDA Akio Natl. Cardiovasc. Crt. Res. Inst., Dept. of Bioengineering, 生体工学部, 研究員 (60224929)
ECHIGO Shigeyuki Natl. Cardiovasc. Crt. Pediatrics Dept., 小児科, 医長
越後 茂之 国立循環器病センター病院, 小児科, 医長
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 1991: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1990: ¥3,200,000 (Direct Cost: ¥3,200,000)
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| Keywords | Artificial Occluder / Intravascular Surgery / Shape-memory Polymer / 動脈閉鎖術 |
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| Research Abstract |
A novel percutaneous patent ducturs arteriosus (PDA) occlusion technique, without the potential problems associated with conventional techniques, has been long awaited. The development of a novel transvenous PDA occlusion technique using a temperature-shape changeable occluder device, and the verification of its in vitro performance, were demonstrated in this study. The principles of this technique : 1) the bar form device was inserted into the PDA transvenously by a guide wire and a pushing catheter, 2) the device was dashed with hot water through catheters, 3) the device was expanded by hot water in the PDA, and the PDA was occluded. The occluder device, made of a shape memory polymer (polynorbornene), was designed to have the monobloc configuration of a thin disk with a hole for a guide wire in the center and a cone. The barlike device by hot press was fully expanded within 10 sec upon immersion into 45ﾟC water. The mock-circulation test with the "great arteries" and a specially designed "PDA" showed 1) the introduction water (45ﾟC) through the catheters caused expansion of the device which stayed in the "PDA" without any support, 2) the "aortic" pressure and the distal "aortic" flow increased rapidly, and the "pulmonary" flow reduced promptly. This resulted in a drastically reduced shunt ratio at the PDA from 68% to 30%. Thus, the novel PDA occlusion technique developed here functioned well to occlude the PDA in a great arteries model.
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