• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular design and synthesis of new retinoids

Research Project

Project/Area Number 02557084
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionUniv. of Tokyo

Principal Investigator

SHUDO Koichi  Univ. Tokyo, Prof., 薬学部, 教授 (50012612)

Co-Investigator(Kenkyū-buntansha) KAGECHIKA Hiroyuki  Univ. Tokyo Assist Prof., 薬学部, 助手 (20177348)
OHWADA Tomohiko  Univ. Tokyo, Assist Prof., 薬学部, 助手 (20177025)
橋本 祐一  東京大学, 応微研, 助教授 (90164798)
遠藤 泰之  東京大学, 薬学部, 講師 (80126002)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 1992: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1991: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1990: ¥4,800,000 (Direct Cost: ¥4,800,000)
Keywordsretinoid / vitamin A / retinoic acid / retinoid antagonist / cancer / leukemia / differentiation / retinoid receptor / 分化 / レチノイドレセプタ- / 分子設計 / HL60 / 核レセプタ- / ビタミンA酸 / 形態形成 / 癌治療 / シリコン
Research Abstract

Molecular design ant synthesis of retinoids were practiced toward possible therapeutic applications.
1. New retinoids containing a trimethylsilyl or trimethylgermyl moiety were prepared. Some of them are very stong in the differentiation inducing bioassay.
2. Trans amide conformation of some synthetic retinoids is proved more important for the strong biological activity.
3. Retinoid receptors were expressed in animal cells and also in E. Coli. Using these receptors binding constants of several synthetic retinoids were evaluated.
4. Fluorescent retinoid probes were prepared.
5. Retinoid antagonists were synthesized for the first time.
6. An in vitro cancerstatic activity was tested using a malignant transformation model.
7. Three retinoid symposiums were held during the term, where some of the results were presented.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] YAMAKAWA et al: "Retinobenzuic acid.5." J.Med.Chem.33. 1431-1437 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] TAMURA et al: "Synthetic retinoids regulate morphogenesis in chick limd bud." Cell Different.Develop. 32. 17-26 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] HASHIMOTO et al: "Expression of retinoic acid recepfor qenes and the ligand binding selectivity." Biochem.Biophys,Res,Com.166. 1300-1307 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 首藤: "レチノイン酸の作用機構" 最新医学. 46. 2213-2217 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 首藤他: "レチノイドとがん" Critical Review Cancer. 1. 108-106 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] FUKASAWA et al: "Expression of ligand binding clomeinconteining region of retimoic acid receptors." Biol,Pharm,Bull.16. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 橋本他: "レチノイド" 講談社, 188 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 首藤他: "Advauce in Drug Research" Academic Press, (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T. Yamakawa et al: "Retinobenzoic acids 5." J. Med. Chem.33. 1431-1437 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K. Tamura et al: "Synthetic retinoids regulate morphogenesis in chick limb bud." Cell Different. Develop.32. 17-26 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y. Hashimoto et al: "Expression of retinoic acid receptor genes and the ligand binding selectivity." Biochem. Biophys. Res. Commun.166. 1300-1307 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K. Shudo: "Retinoic acid: Function and Mechanism" Saishin Igaku. 46. 2213-2217 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K. Shudo et al: "Retinoids and Cancer" Critical Review Cancer. 1. 106-108 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H. Fukasawa et al: "Expression of ligand binding domaincontaining region of retinoic acid receptors." Biol. Pharm. Bull.16. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y. Hashimoto et al: "Retinoids" Koudanshya Co. Ltd.(1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K. Shudo et al: "Advance in Drug Research" Academic Press. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] L.Eyrolles: "Retinoid.antagonists" Med.Chem.Res.2. 361-367 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 首藤 紘一: "レチノイドとがん" CRC(中山書店). 1. 108-116 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 首藤 紘一: "ビタミンAの働き" 日本香粧品学会誌. 16. 172-174 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] H.Tanaka: "Base-catalyzed isomerization of rutinoic acel." J.Med.Chem.35. 567-572 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 首藤 紘一: "レチノイド" 講談社サイエンティフィツ., 188 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] R.Shimazawa他: "Fluorescent and Photoaffinity Labelling prolees for retinoic and receptors" Biochem.Biophys.Res.Qommun.179. 259-265 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 首藤 紘一: "レチノイン酸の作用機構" 最新医学. 46. 2213-2217 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Y.Hashimoto,K.Shudo: "Retinoids and their nuclear receptors" Cell Biol.Rev.25. 209-230 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Y.Fujimori etal: "Enantio-and mcso oligodeoxy ribonucleic aeids" Nucl.Acid.Res.(S). 23. 143-144 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Y.Hashimoto,K.Shudo: "Cytosolic nuclear tumor promster specific binding protein." Jpan.J.Cancer Res.82. 662-675 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Yamakawa: "Retiro binzoic Acids S." J.Med.Chem.33. 1930-1937 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Hashimoto: "Expression of refiroic acid recepton glves," Biochem.Biophys.Res.Com.166. 1300-1307 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Tamura: "Synthetic Retinoids regulate morphogenea's in chide limb bud." Cell.Diff.Develop. 32. 17-26 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 首藤 紘一: "発がんと制がんの化学" 広川書店, 247 (1990)

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi