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Development of Heat Generating Magnetic Materials for Hyperthermia and Application to Medical Treatment

Research Project

Project/Area Number 02559008
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionNagoya university

Principal Investigator

MATSUI Masaaki  Nagoya Univ.School of Engineering Professor, 工学部, 教授 (90013531)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Tatsuya  Komaki City Hospital Vice Director, 副院長 (10093030)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 1992: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1991: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1990: ¥8,500,000 (Direct Cost: ¥8,500,000)
KeywordsInterstitial heating / hyperthermia / heat generating materials / Fe-Pt alloys / Mg-Ca Ferrites / Silane-coating / eddy current loss / hysteresis loss / フェライト / ガラスコ-ティング / FeーPt合金 / 溶出試験
Research Abstract

The implant materials for hyperthermia of cancer tissues were developed and the clinical investigations were performed. Results of the research are summarized as follows :
1. The corrosion resistance of the Fe-Pt alloy implant material for hyperthermia, which has low Curie point and large heat generation through the eddy current loss, is larger than that of a stainless steel. However, when the implant was embedded in the tissue of the thigh of a rabbit, the dissolved Fe element was a little bit detected in the X-ray analysis(1.0 x 10^<-4> g/cm^2 month).
2. In order to prevent the alloy elements from dissolving, the biocompatible compound SiO_2 was coated on the implant using silane and phosphorus acid. The coating improved the corrosion resistance remarkably.
3. The powder samples of Fe-Pt alloys were prepared as a heat generation materials through magnetic hysteresis loss. The heat generation of the powder material was enough to be used for hyperthermia. A spray-drying method was developed for the SiO_2 coating of the powder particles.
4. The ceramic materials of CaO-MgO-Fe_2O_3 system whose elements are all biocompatible were investigated as new powder implant materials for hyperthermia. It was found that the materials of x=0.525 for (MgO)_<1-x>(Fe_2O_3)_x and y=1.0 for (CaFe_4O_7)_<1-y>(MgFe_2O_4)_y have the large heat generation through hysteresis loss which is several times larger than that of Fe_3O_4. The curie points of the materials are lower than that of Fe_3O_4.
5. The clinical treatment for brain tumors and tongue tumors were tried for several cases using Fe-Pt alloy implants. The effects of hyperthermia were remarkable, 45.5% for brain tumors and 100% for tongue tumors.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (50 results)

All Other

All Publications (50 results)

  • [Publications] 小林 達也: "インプラントヒーティングシステム(IHS)を用いた悪性脳腫瘍の組織内温熱療法" NEUROLOGICAL SURGERY(脳神経外科). 18. 247-252 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 後藤 康之: "Implant Heating Systemによる口腔悪性腫瘍に対する組織内温熱療法-家兎腫瘍モデルによる検討-" 日本ハイパーサーミア誌. 6. 439-449 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 藤内 祝: "舌癌に対するImplant Heating Systemによる組織内温熱療法" 日本ハイパーサーミア誌. 6. 450-461 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.TOHANAI: "The Treatment of Oral Cancer by Interstitial Hyperthermia with an Implant Heating System" Hyperthermic Oncology in Japan'89. 150-151 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.NAKAGAWA: "Experiment on Hyperthermia by Low Frequency (LF) Induction Heating Method" Hyperthermic Oncology in Japan'89. 196-197 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.MATSUI: "Materials Scientific Research on the Powder Implant Materials" Hyperthermic Oncology in Japan'89. 210-211 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.GOTO: "Antitumor Effect of Interstitial Hyperthermia Using Implant Heating System.-Experimental Study on Rabbit Lower Thigh Muscle and Togue Tumor Model-" Hyperthermic Oncology in Japan'89. 404-405 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.KOBAYASHI: "Interstitial Hyperthermia of Brain Tumors Using Induction Heating of Ferromagnetic Implants with Low Curie Temperture" Progr.in Electromagnetic Research Symp.(PIERS)1991 Proceedings. 198 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.KOBAYASHI: "Interstitial Heating of Tumor Tissue by Implant Heating System(IHS)" Hyperthermic Oncology in Japan'90. 71-74 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.TOHNAI: "The Histopathological Effects of Hyperthermo-Chemotherapy Using Implant Heating System for Oral Cancer" Hyperthermic Oncology in Japan'90. 99-100 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.MITSUDO: "Development of a Platinel Thermocouple using Implant Heating System(IHS)" Hyperthermic Oncology in Japan'90. 223-224 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.MATSUI: "Heat Generation of the Powder Magnetic Implant Materials" Hyperthermic Oncology in Japan'90. 243-244 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.KAWAMOTO: "Ceramic Implant Materials for Hyperthermia" Hyperthermic Oncology in Japan'91. 225-226 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.SHIMIZU: "Coating Effect of Fe-Pt Implant Alloy" Hyperthermic Oncology in Japan'91. 279-280 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.GOTO: "Experimental Study on Effects of Hyperthermo-Chemotherapy for Oral Malignant Tumor Using Implant Heating System" Hyperthermic Oncology in Japan'91. 293-294 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.TOHNAI: "The Study of The Hyperthermochemotherapy of Oral Cancer Using Implant Heating System-Anticanceraus Effects of Temperature-Sensitive Liposomes Containing Cisplatin on VX-7 Rabbit Tongue Tumor Model-" Hyperthermic Oncology in Japan'91. 299-300 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.KAWAMOTO: "Ceramic Implant Materilas For Hyperthermia II" Hyperthermic Oncology in Japan'92. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Kobayashi: "Interstitial Hyperthermia of Malignant Brain Tumors using Implant Heating System(IHS)" NEUROLOGICAL SURGERY. Vol.128. 247-252 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Goto: "Interstitital Hyperther ; mia for Oral Malignant Tumor using Implant Heating System. -Experimental Studies on Rabbit Tumor Model.-" Jpn.J.Hyperthermic Oncol.Vol.6. 439-449 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.Tohnai: "Interstitial hyperthermia for Cancer of the Tongue using an Implant Heating System" Jpn.J.Hypertherimc Oncol.Vol.6. 450-461 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.Tohnai: "The Treatment of Oral Cancer by Interstitial Hyperthermia with an Implant Heating System" Hlyperthermic Oncology in Japan. 89. 150-151 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Nakagawa: "Experiment on Hyperthermia by Low Frequency(LF) Induction Heating Method" Hyperthermic Oncology in Japan. 89. 196-197 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Matsui: "Materials Scientific Research on the Powder Implant Materials" Hyperthermic Oncology in Japan. 89. 210-211 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Goto: "Antitumor Effect of Interstitial Hyperthermia Using Implant Heating System. -Experimental Study on Rabbit Lower Thigh Muscle and Togue Tumor Model-" Hyperthermic Oncology in Japan. 89. 404-405 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Kobayashi: "Interstitial Hyperthermia of Brain Tumors Using induction Heating of Ferromagnetic Implants with Low Curie Temperture" Progr.in Electromagnetic Research Symp.(PIERS) 1991 Proceedings. 198. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Kobayashi: "Interstitial Heating of Tumor Tissue by Implant Heating System(IHS)" hyperthermic Oncology in Japan. 90. 71-74 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.Tohnai: "The Histopathological Effects of Hyperthermo-Chemotherapy Using Implant Heating System for Oral Cancer" Hyperthermic oncology in Japan. 90. 99-100 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Mitsudo: "Development of a Platinel Thermocouple using Implant heating System(IHS)" Hyperthermic Oncology in Japan. 90. 223-224 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Matsui: "Heat Generation of the Powder Magnetic Implant Materials" Hyperthermic Oncology in Japan. 90. 243-244 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Kawamoto: "Ceramic Implant Materials for Hyperthermia" Hyperthermic Oncology in Japan. 91. 225-226 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Shimizu: "Coating Effect of Fe-Pt Implant Alloy" Hyperthermic Oncology in Japan. 91. 279-280 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Goto: "Experimental Study on Effects of Hyperthermo-Chemotherapy for Oral Malignant Tumor Using Implant Heating System" Hyperthermic Oncology in Japan. 91. 293-294 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] I.Tohnai: "The Study of The Hyperthermochemotherapy of Oral Cancer Using Implant Heating System-Anticanceraus Effects of Temperature-Sensitive Liposomes Containing Cisplatin on VX-7 Rabbit Tongue Tumor Model-" Hyperthermic Oncology in Japan. 91. 299-300 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Kawamoto: "Ceramic implant Materilas For Hyperthermia II" Hyperthermic Oncology in Japan. 92. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Kawamoto: "Ceramic Implant Materials for Hyperthermia" Hyperthermic Oncology in Japan '91. 225-226 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Shimizu: "Coating Effect of Fe-Pt Implant Alloy" Hyperthermic Oncology in Japan '91. 279-280 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Goto: "Experimental Study on Effects of Hyperthermo-Chemotherapy for Oral Malignant Tumor Using Implant Heating System" Hyperthermic Oncology in Japan '91. 293-294 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] I.Tohnai: "The Study of The Hyperthermochemotherapy of Oral Cancer Using Implant Heating System-Anticanceraus Effects of Temperature-Sensitive Liposomes Containing Cisplatin on VX-7 Rabbit Tongue Tumor Model-" Hyperthermic Oncology in Japan '91. 299-300 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Kawamoto: "Ceramic Implant Materials For Hyperthermia II" Hyperthermaic Oncology in Japan '92. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Kobayashi: "Interstitial Heating of Tumor Tissue by Implant Heating System(IHS)" Hyperthermic Oncology in Japan '90. 71-74 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] I.Tohnai: "The Histopathological Effects of Hyperthermo-Chemotherapy Using Implant Heating System for-Oral Cancer" Hyperthermic Oncology in Japan '90. 99-100 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Mitsudo: "Development of a Platinel Thermocouple Using Implant Heating System(IHS)" Hyperthermic Oncology in Japan '90. 223-224 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Matsui: "Heat Generation of the Powder Magnetic Implant Materials" Hyperthermic Oncology in Japan '90. 243-244 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Kobayashi: "Interstitial Hyperthermia of Brain Tumors Using Induction Heating of Ferromagnetic Implants with Low Curie Temperature" PIERS 1991 Proceedings. 198- (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] I.Tohnai: "The Temperature of Oral Cancer by Interstitial Hyperthermia with an Implant Heating system" Hyperthermic Oncology in Japan '89. 150-151 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Nakagawa: "Experiment on Hyperthermia by Low Frequency (LF) Induction Heating Method" Hyperthermic Oncology in Japan '89. 196-197 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Matsui: "Materials Scientific Research on the Powder Implant Materials" Hyperthermic Oncology in Japan '89. 210-211 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Goto: "Antitumor Effect of Interstitial Hyperthermia Using Implant Heating System.ーExperimental Study on Rabbit Lower Thigh Muscle and Togue Tumor Modelー" Hyperthermic Oncology in Japan '89. 404-405 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Matsui: "Magnetic Ordering in Superconducting YBa_2(Cu_<1ーX>Fe_X)_3O_y" J.Nuclear Materials. 170. 211-216 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松井 正顕: "MBE超薄膜fccーFe/Cuの磁気異方性" 日本応用磁気学会誌. 14. 339-342 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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