| Project/Area Number |
02559009
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
広領域
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
MARUNO Sigeo Nagoya Institute of Technology Dept. Electri. and Comput. Eng., Prof, 工学部, 教授 (60024204)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Tomoji Dept. Orthop. Surg., Tokyo Koseinenkin Hosp. Doctor, 整形外科医師
KAWAGUCHI Takeshi N. I. T., Dept. Electri. and Comput. Eng., Lecturer, 工学部, 講師 (80144195)
BAN Seiji School of Dentistry, Aichi-Gakuin Univ. Lecturer, 歯学部, 講師 (10159105)
ITOH Haruo Dept. Orthop. Surg., Tokyo Koseinennkinn Hosp. Director, 整形外科部長
IWATA Hisashi Dept. Orthop. Surg., Nagoya Univ. Asso. Prof, 医学部, 助教授 (90023796)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 1991: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1990: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Keywords | Bioimplant / Bio-Functionally Grad. Composite / Artificial bone replacement Mat. / Hydroxyapatite Composite / Cementless hip joint / Artificial tooth root |
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| Research Abstract |
Hydroxyapatite(HA) containing glass(G)-coated titanium(Ti) or titanium alloy (Ti-6Al-4V) composite materials, so-called HA-G-TI functional gradient composite and provide both bioactivity potential due to the HA and mechanical strength of titanium, were developed for dental implant and artificial hip joint and were subject to the experiments in vitro and in vivo conditions as described later. The HA-G-TI composite implants can be prepared comparatively easily by a conventional coating technique such as enameling. The reaction of the glass frit and HA under the firing process (800-950ﾟC), bonding strength of glass to Ti substrate, hardness and compressive strength of HA-G ceramics were examined. The glass-frit used in this work was alumina-borosilicate glasses, having a linear thermal expansion coefficient several percent smaller than those of the Ti and Ti-6Al-4V. It was found that the most suitable etching condition for preparing a bioactive surface layer on HA-GmTi composite, wherein
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the surface layer is a ro-ughened. state having exposed HA fine particles sticked together with glass matrix, is obtained by the chemical etching in mixture solution of 3% HA and 5% HNO, for 2-3min. The results of the chemical stability and electrochemical corrosion of the HA-G-TI composite in simulated body fluid (SBF : pH=7.1), O. OOIN HCI solution (pH=2.8), distilled water (pH=5.8) and 0.01% ammonia solution (pH=10.6) showed that the composite is chemically stable in biological environments and has useful biocompatible characters and further the glass phase of the composite could be electrochemically stable and suppresses the dissolution of HA and Ti. The implant experiments of the HA-G-TI composite into mandibular bore and femur and tibia of Beagle dogs were made over various periods of time (1-38 month), and the biological bonding behavior at the interface between the implants and the surrounding bone tissue as well as the bonding strength and histological aspect was investigated. Any foreign body reaction and inflammatory one were not observed for the application in dental and medical fields. The average bonding strength (pull-out test) was 10.3, 13.8 and 14.8MPa for 1, 2 and 3 month implantation in dog femur, respectively. It was found that apposition of bone to the implant was resulted from bone ingrowth into the HA-G coating layer as well as direct bonding between bone and implant. The structural natures of newly formed bone and the calcified bone around the implants were clarified. In the cell culture examination using osteoblast like cell MC3T3-El, the proliferation of osteogenic cell was markedly observed. We conclude through these experimental studies that the HA-G-TI composite is excellent biomaterial applicable to the cementless artificial joint and endosseous dental implant. Less
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