• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular biological study on mechanisms underlying regulation of beta-adrenoceptors

Research Project

Project/Area Number 02670094
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionNagoya City University

Principal Investigator

FUJIMOTO Seigo  Nagoya City University Medical School, Department of Pharmacology, Associate Professor, 医学部, 助教授 (60079994)

Co-Investigator(Kenkyū-buntansha) MATSUDA Tomohiro  Nagoya City University Medical School, Department of Pharmacology, Professor, 医学部, 教授 (40028361)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1991: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1990: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsbeta_1-Adrenoceptor / beta_2-Adrenoceptor / Spontaneously hypertensive rat / Vasorelaxation / Vasoconstriction / Isoproterenol / Propranolol / βーアドレナリン受容体 / ムスカリン受容体 / プリン受容体
Research Abstract

Arteries isolated from rats were suspended in physiological salt solution and beta-adrenoceptor (AR)-mediated vasorelaxation was investigated. It was found that beta-AR in femoral arteries and aortas were of beta, and beta_2 subtypes, respectively. Effects of norepinephrine (NE) on blood vessels were summation of alpha-AR-mediated vasoconstriction and beta-AR-mediated vasorelaxation. The contractile response of the femoral artery to NE was potentiated by propranolol and atenolol but not butoxamine. On the other hand, the contractile response of the aorta to NE was increased by butoxamine. Thus, it was found that vascular effects of NE, an adrenergic neurotransmitter, were modulated by activities of beta_1- and, beta_2-AR, in the femoral artery and aorta, respectively.
Rats were treated substaneously with some drugs for 7-10 days. Femoral arteries isolated from these rats were suspended in physiological salt solution. In vitro response to NE (mediated through beta_1-AR) were potentiated by subcutaneous propranolol and attenuated by subcutaneous isoproterenol. Thus, it was found that beta_1-AR-mediated effects were modulated by systemic administration of beta-AR agonists and antagonists
On femoral arteries of spontaneously hypertensive rats, it was found that vasoconstriction effects of NE were increased by decrease in beta_1-AR-mediated response.
In summary, it was suggested that systemic administration of drugs modulates beta-AR activity leading to changes in vascular responses mediated through beta-AR.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Seigo Fujimoto: "M_3 Cholinoceptors and P_2y purinoceptors mediating rela xation of arteries in spuntaneously hypertensiue rats at prehypertensiue stages" Eurapean Jaurnal of Pharmacalogy. 202. 9-15 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Seigo Fujimoto: "Autoradio graphie localization of beta-1 and beta-2 adrenoceptors in rat blooel uessols" The Japanese Journal of Pharmacology Supplementum I. 55. 174 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 藤本 征五: "高血圧自然発症ラット動脈のβ_1とβ_2アドレナリン受容体サブタイプを介した弛緩反応" 脈管学. 31. 999 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 藤本 征五: "新しいβ_3ーアドレナリン受容体の単離と薬理学的役割" 薬局. 43. 89-96 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Fujimoto, Seigo: "M_3 Cholinoceptors and P_2 purinoceptors mediating relaxation of arteries in spontaneously hyper-tensive rats." European Journal of Pharmacology. 202 (1). 9-15 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Fujimoto, Seigo: "Autoradiographic localization of beta-1 and beta-2 adrenoceptors in rat blood vessels." The Japanese Journal of Pharmacology. 55 (Supl.). 174 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Fujimoto, Seigo: "beta_1- and beta_2-Adrenoceptor-mediated relaxation of arteries from Spontaneously hyper-tensive rats." The Journal of Japanese College of Angiology. 31 (9). 999 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Fujimoto, Seigo: "Isolation and pharmacological roles of novel beta_3-adrenoceptors." The Journal of Practical Pharmacy. 43 (1). 89-96 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Seigo Fujimoto: "M_3 cholineeceptors and Pzy purinceceptors mediating relaxation of arteries in spontaneously hypertensuie rats at prohypes tensive stages." European Journal of Pharmacology. 202. 9-15 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Seigo Fujimoto: "Autoraclio graphical loealization of betaー1 and betaー2 adrenoceptors in rat blood uessels." The Japanese Jaurnal of Pharmacalogy Supplement I. 55. 174 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 藤本 征五: "高血圧自然発症ラット動脈のβ_1とβ_2アドレナリン受容体サブタイプを介した弛緩反応" 脈管学. 31. 999 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 藤本 征五: "新しいβ_3ーアドレナリン受容体の単離と薬理学的役割" 薬局. 43. 89-96 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 藤本 征五: "高血圧自然発症ラット(SHR)の摘出血管のムスカリンM_2とプリンP_<2y>受容体を介する弛緩反応" 脈管学. 30. 805 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Seigo Fujimoto: "Effects of chalinoceptor and purinoceptor agonists on arteries from spontaneously hypertensive rats (SHR)" The Japanese Journal of Pharmacalogy, Supplementum. 52. 108 (1990)

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi