• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of Endogenous Adenosine in Hypoxic Ventilatory Depression

Research Project

Project/Area Number 02670333
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionHokkaido University

Principal Investigator

NISHIMURA Masaharu  Hokkaido University Medical School, Instructor, 医学部附属病院, 助手 (00208224)

Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsHypoxic Ventilatory Reponse / Adenosine / Dipyridamole / Brain Tissue / Ventilatory Depression / Theophylline / Human / 低酸素 / 換気応答 / 低酸素換気抑制 / (theophylline)テオフィリン / (adenosine)アデノシン / 脳血流
Research Abstract

Study (I)
We studied the effect of theophylline, an adenosine receptor antagonist, on the tissue oxygenation and acid-base status in the brain in healthy volunteers (n=6). Partial gas pressures and oxygen saturation (SO2) in an artery and the internal jugular vein were simultaneously measured during normoxia and isocapnic hypoxia (PaO2=60, 45 mmHg) before and after infusion of theophylline. PjO2 as well as SjO2 markedly dropped after theophylline infusion. On the other hand, PjCO2 and pHj did not change in the two studies despite slightly but significantly low PaCO2 and high pHa with theophylline. Based on the assumption that parameters of jugular venous blood reflect those of the brain tissue, these data provide insight into the mechanism of ventilation-stimulating effect of theophylline and suggest a possible adverse effect of theophylline on the brain.
Study (II)
To examine a role of endogenous adenosine in hypoxic ventilatory response, we measured, in nine normal adults, ventilatory r … More esponses to isocapnic progressive and subsequent sustained hypoxia with and without pretreatment with dipyridamole, an adenosine uptake blocker, which increases plasma levels of adenosine. Pretreatment with dipyridamole significantly augmented the slope of the ventilatory response to isocapnic progressive hypoxia, suggesting a possible role of endogenous adenosine for the activity of peripheral chemoreceptors. During 20 min of sustained hypoxia, ventilation gradually declined to intermediate levels in both studies. However, the decline in ventilation began earlier and was more marked with dipyridamole. When theophylline alone, adenosine receptor antagonist, was injected in 4 out of 9 subjects, the ventilatory decline seen during sustained hypoxia was attenuated. In addition, dipyridamole following theophylline infusion no longer produced any significant change on ventilatory response to sustained hypoxia compared to theophylline alone. We therefore conclude that endogenous adenosine may play a modulatory role both peripherally and centrally in hypoxic ventilatory response in humans. Less

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] M.Nishimura: "Effect of aminophylline on brain tissue oxygenation in patients with chronic obstructive pulmonary disease" Thorax. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Nishimura: "Effect of theophylline on brain tissue oxygenation during normoxia and hypoxia in humans" Lancet.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Yamamoto: "Role of endogenous adenosine in hypoxic ventilatory response in humans. A study with dipyhridamole." J.Appl.Physiol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Nishimura,et by Y.Honda et al.: "Proceedings of 5th Oxford Conference-Control of Breathing and its Modeling Perspective-" Plenum Publishing Corporation, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Nishimura: "Effect of aminophylline on brain tissue oxygenation in patients with chronic obstructive pulmonary disease." Thorax. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Nishimura: "Effect of theophylline on brain tissue oxygenation during normoxia and hypoxia in humans." Lancet. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Yamamoto: "Role of endogenous adenosine in hypoxic ventilatory response in humans. A study with dipyridamole." J. Appl. Physiol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Nishimura: "Effect of theophylline on brain acid-base status during normoxia and hypoxia in humans." Proceedings of 5th Oxford Conference-Control of Breathing and its Modeling Perspective -. Plenum Publishing Corporation. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Nishimura,et al: "Longitudinal analyses of respiratory chemosensitivity in normal subjects" Am.Rev.Respir.Dis.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Nishimura,et al: "Adverse effecf of theophylline on brain tissue oxygenation in bypoxemic patients with chromc obstructive pulmonary disease" Thorax.

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi