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Study on the Pathophysiology of Experimental Vascular Dementia in Gerbils using Magnetic Resonance Methods

Research Project

Project/Area Number 02670375
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionNational Cardiovascular Center

Principal Investigator

NARITOMI Hiroaki  National Cardiovascular Center Cerebral Circulation Laboratory Director, 循環動態機能部, 室長 (60132932)

Co-Investigator(Kenkyū-buntansha) SASAKI Masahiro  National Cardiovascular Center Radio-Isotope Experimental Institute Faculty, 生体工学部, 研究員 (50150800)
KANASHIRO Masaru  National Cardiovascular Center Department of Biochemistry Faculty, 共通実験室, 研究員 (10132929)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1990: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsvascular dementia / chronic low perfusion / cerebral ischemia / 31P NMR spectroscopy / monogolian gerbils / arterial stenosis / behavioral abnormality / Cerebral blood flow / 慢性低潅流 / 脳循環 / 脳エネルギ-代謝
Research Abstract

In patients with vascular dementia, cerebral arteries are usually narrowed, and cerebral blood flow is reduced constantly. In order to clarlfy the role of arterial stenosis In the pathophysiology of vascular dementia, both common carotld arteries were narrowed in gerbils, and chronic effects of arterial stenosls were studied. In experiment 1, the common carotid arteries were narrowed by silver clips wlth 0.1 x 1.0 mm in diameter and 2.0 mm in length. The stenosis caused severe blood flow reduction of below 0.20 mi/g/min in 40% of animals and moderate flow reduction in the remaining 60% of animals. 40% of animals developed energy failure and died within 4 days after the stenosis. The remalning 60% of animals had no energy impairments as judged by in vivo 31P nuclear magnetic resonance spectroscopy (MRS) and remained free from ischemic symptoms. Histological examinations in these asymptomatic animals exhibited no ischemic change at 1 day after the stenosis. At 5 days, 4 weeks and 3 month … More s after stenosis, 40%, 53% and 60% of animals showed ischemic changes. Ischemic changes included large hemisphric cerebral infarction (type 1), multiple small infarction (type 2) and small patchy changes consisting of neuronal cell death (type 3). Type 3 ischemia was observed at 4 weeks and 3 months after the stenosls and most commonly seen in the cerebral cortex and strlatum. At 2 weeks and 3 months after the stenosls, these ischemic. animals exhibited remarkable depresslon of learning ability. In experiment 2, flve different grades of stenosis was produced at both common carotid arteries using polyethylene tubes with 0.28-0.58 mm in diameter and 2.0 mm in length. In the group with severe stenosis, secondary thrombus formation occurred at the carotid arteries leading to energy impairments and acute death. In the group with intermediate grade stenosis, carotid thrombus was seen in 30% of animals which developed type 1 or 2 ischemia. In the remaining animals, no carotid thrombus was observed, yet, type 3 ischemia was frequently observed. In the groups with moderate to mild grade stenosis, little ischemic changes resulted. Type 1 or 2 ischemia is probably caused by thrombotic arterial obstruction or artery-to-artery embolism. Type 3 ischemia is unlikely to result from such mechanism and is presumably attributable to chronic low perfusion. The results suggest that chronic low perfusion may produce small patchy ischemia in the brain and may play a role in the pathophysiology of vascular dementia. Less

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Naritomi H,Sasaki M,Kanashiro M,et al.: "Experimental approaches to vascular dementia." Recent Adv Cardiovasc Dis. 11. S61-68 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Kanashiro M,Naritomi H,et al.: "Non-invasive ^<31>P NMR study on the development of brain membrane of gerbils and jimpy mice,a myelin-deficient mutant." Physiol Chem Phys & med NMR. 22. 141-154 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 成冨 博章: "画像診断からみた白質:MRIにおけるPVHの意味" 臨床神経. 30. 1345-1347 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 成冨 博章,佐々木 將博: "脳虚血と精神機能。実験的脳虚血と学習,記憶障害。" 循環器病研究進歩. 11. 152-159 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Naritomi H: "Experimental basis of multi-infarct dementia:Memory impairments in rodent models of ischemia." Alzheim Dis Relat Dis. 5. 103-111 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Naritomi H,Sasaki M,Suzuki M,et al.: "Magnetic resonance spectroscopy for evaluation of cerebral metabolism." Recent Adv Cardiovasc Dis. 12. S49-54 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Naritomi H,Sasaki M: "Microcirculatory Disorders in the Heart and Brain" Harwood Academic Publ Chur,London,Paris,New York,Melbourne, 163-173 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Rogers RL, Meyer JS. Mortel KF. Mahurin RK, Judd BW: "Decreased cerebral blood flow precedes multi-infarct dementia, but follows senile dementia of Alzheimer type." Neurology. 36. 1-6 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Naritomi H, Sawada T, Kuriyama Y, Kinugawa H, Kaneko T, Takamiya M: "Effect of chronic middle cerebral artery stenosis on the local hemodynamics." Stroke. 16. 214-219 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Naritomi H, Sasaki M. Kanashiro M, Kitani M, Sawada T: "Flow threshold for cerebral energy disturbance and Na+ pump failure as studied by in vivo 31P and 23Na nuclear magnetic resonance spectroscopy." J Cereb Blood Flow Metab. 8. 16-23 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Naritomi H: "Experimental basis of multi-infarct dementia:Memory impairments in rodent models of ischemia." Alzheim Dis Assoc Dis. 5. 103-111 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Naritomi H,Sasaki M,Suzuki M,et al.: "Magnetic resonance spectroscopy evaluation of cerebral metabalism." Recent Adv Cardiovasc Dis. 12. S49-54 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Naritomi H,Sasaki M: "Microcirculatory Disorders in the Heart and Brain" Harwood Acadeic Publ Chur,Lodon,Paris,New York,Melbourne, 163-173 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Naritomi H,Sasaki M,Sawada T,Izuta M,Kadota E,Hashimoto S: "Multiple infarcts,ventricular enlargement and behavioral changes caused by chronic carotid artery stenosis in prbils." J Cereb Blood Flow Metabol. 11. (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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