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A new approach of long-term monitoring and automated bioinformation processing system in Neonatal Intensive Care Unit

Research Project

Project/Area Number 02670450
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionOita Medical University

Principal Investigator

OGAWA Teruyuki  Oita Medical University, Department of Pediatrics, Professor, 医学部, 教授 (10039810)

Co-Investigator(Kenkyū-buntansha) GOTO Kazuya  Oita Medical University, Dept of Pediat., assistant professor, 医学部, 講師 (90178442)
ISHIWA Shun  Oita Medical University, Dept of Pediat., assistant professor, 医学部, 講師 (50159787)
大林 洋美  大分医科大学, 附属病院, 助手 (40168886)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1990: ¥900,000 (Direct Cost: ¥900,000)
Keywordsautoregressive analysis / bioinformation processing / RR interval / electroencephalogram / blood pressure / autonomic nervous system / T_CPO_2 / NICU / 新生児 / 解析システム / 自己回帰モデル / インパルス応答 / ノイズ寄与率 / 中枢性睡眠時無呼吸症候群 / 呼吸・心拍制御応答 / 新生児生体情報 / 情報解析システム / スペクトル解析 / 夛次元自己回帰モデル / 新生児医療 / 睡眠段階自動判定
Research Abstract

The brains of newborns admitted to intensive care units are at considerable risk. Since July of 1988, we have developed the bioinformation processing system of very premature infants during 30 days following right after birth in the neonatal intensive care unit of Medical University Hospital in Oita. The computers were programmed to automatically obtain the measurement on EEGs, heart rate, TcPO_2 and blood pressure from monitoring system, display and store the current values, retrieve post data with the using an autoregressive (AR) spectral analysis method. By using the system, the following results were obtained.
1. The EEG was divided into two distinct patterns ; trace-alternant activity and continuous activity. The system was conducted to automatically quantify sequential changes in EEG continuity for 24h in very premature infants.
2. Quantitative parameters of cardiac RR intervals in fetus and preterm infants were automatically calculated at 26 to 40 posteonceptional weeks by using an AR model.
3. Respiratory frequencey, blood pressure and heart rate were computed to generate evenly spaced signals at 200ms interval and calculated the power spectral density by AR model.
4. We applied spectral analysis through multivariant AR model fitting to RR interval and respiratory oscillations obtained during quiet sleep in healthy preterm infants and an infants with congenital central hypoventilation syndrome (Ondine's curse). Nois contribution ratio between respiratory and RR were calculated. We postulate that the results shows disturbance of central autonomic control of breathing and heart rate in Online's curse.
These results suggest that the further work should establish normal values and focus on the potential clinical significants of our monitoring and bioinformation processing system in NICU.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] 小川昭之,園田浩富,後藤一也,石和 俊,若山幸一: "新生児長期連続生体情報収集解析システムの開発" 臨床モニター. 1. 553-562 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ishiwa,S.,Ogawa,T.,Sonoda,H.: "Developmental characteristic of topographic EEG in the newborn using an autoregressive model." Brain Topography. 4. 23-30 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Goto,K.,Wakayama,K.,Sonoda,H.,Ogawa,T.: "Sequential changes in electroencephalogram continuity in very premature infants." Electroenceph.Clin.Neurophysiol.82. 197-202 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ogawa,T.,Kojo,M.,Fukushima,N.,Sonoda,H.,Goto,K.,Ishiwa,S.,Ishiguro,M.: "Cardio-respiratory control in an infant with Ondine's curse:a multivariate autoregressive modelling approach." J.Autonom.Nerv.Syst.42. 41-52 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Wakayama,K.,Ogawa,T.,Goto,K.,Sonoda,H.: "Development of ultradian rhythm of EEG activities in premature babies." Early Hum.Develop.32. 11-30 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ogawa,T.,Sonoda,H.,Ishiwa,S.: "An application of autoregressive model to pattern discrimination of brain electrical activity mapping." Brain Topography 1993.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ishiwa, S., Ogawa, T., Sonoda, H.: "Developmental characteristic of topographic EEG in the newborn using an autoregressive model." Brain Topography. 4(1). 23-30 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Goto, K., Wakayama, K., Sonoda, H., Ogawa, T.: "Sequential changes in electroencephalogram continuity in very premature infants." Electroenceph. Clin. Neurophysiol.82. 197-202 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ogawa, T., Kojo, M., Fukushima, N., Sonoda, H., Goto, K., Ishiwa, S., Ishiguro, M.: "Cardio-respiratory control in an infant with Ondine's curse : a multivariate autoregressive modeling approach." J. Autonom. Nerv. Syst.42. 41-52 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Wakayama, K., Ogawa, T., Goto, K., Sonoda, H.: "Development of ultradian rhythm of EEG activities in premature babies." Early Hum. Develop.32. 11-30 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ogawa, T., Sonoda, H., Ishiwa, S.: "An application of autoregressive model to pattern discrimination of brain electrical activity mapping." Brain Topography. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Goto,K.and Ogawa,T: "Sequential changes in electrocncephalogram continuity in very premeture infants" Electroencephalogr Clin. Neurophysiology. 82. 197-202 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小川 昭之: "自己回帰モデルによる正常胎児心電図PR間隔時系列の解析と、その発達特性:胎児の自律神経機能の動態" 信学技報(電子情報通信学会). 266. 21-25 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 後藤 一也、小川 昭之: "24時間連続脳波記録による早産未熟児の脳波連続性の定量評価" 脳と発達. 24. 449-454 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ogawa.T.,Kojo,M.,Fukushima,M: "Cardio-respiratory control in an infant with Ondines curse:a muttivariate autoregressive modelling approach" J.Autonom.Nern.System. 42. 41-52 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Wakayama,K.,Ogawa,T.,and Sonoda,K.,: "Development of ultradian rhythm of EEG activities in premature babies" Early Auman Development. 32. 11-30 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ogawa,T.,Sonoda,H.,Ishiwa,S.: "Ann application of autoregressire model to patterndiscrimination of frain clectrical activity mapping" Brain Topography. 5. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小川 昭之他: "新生児長期連続生体情報収集解析システムの開発" 臨床モニタ-. 1. 553-562 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小川 昭之他: "未熟児における呼吸と心拍律動の相互応答と、その発達特性(1)静睡眠期" 自律神経. 27. 612-619 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小川 昭之他: "未熟児静睡眠期における心電図RR間隔と血圧間相互応答システム開発" 自律神経. 28. 59-65 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小川 昭之他: "「Ondines curse」児の呼吸・心拍制御応答" 自律神経. 29. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ishiwa S and Ogawa T.: "Developmental characteristic of topographic EEG in the Newborn using an autoregressive model" Brain Topography. 4. 23-30 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Goto,K and Ogawa,T.: "Sequential changes in electroencephalogram continuity in very premature infants" Electroencephalography & Clinical Neurophysiology. 82. 197-202 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小川 昭之,園田 浩富,後藤 一也,若山 幸一: "新生児長期連続生体情報システムの開発" 臨床モニタ-. 1. 553-562 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小川 昭之,園田 浩富,沢田 博人,若山 幸一,後藤 一也: "未熟児における呼吸と心拍律動の相互応答と、その発達特性(I)静睡眠期" 自律神経. 27. 612-619 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小川 昭之,園田 浩富: "未熟児靜睡眠期における心電図RR間隔と血圧間相互応答システムの開発" 自律神経.

    • Related Report
      1990 Annual Research Report
  • [Publications] Ishiwa,S and Ogawa,T: "Developmental characteristics of topographic EEG in the newborn using an autoregressive model" BRAIN TOPOGRAPHY.

    • Related Report
      1990 Annual Research Report
  • [Publications] Goto,K.,Wakayama,K.,Sonoda,H and Ogawa,T.: "Sequential changes in electroencephalogram continuity in very premature infants" Electroencephalogr.Clin.Neurophysiol.

    • Related Report
      1990 Annual Research Report
  • [Publications] Wakayama,K.,Goto.K.,Sonoda,H,& T.Ogawa: "Autoregressive analysis of the fluctuation of EEG in the premature neonates" Proceeding of the Joint Convention of the 5th International Child Neurology Congress (Nov,1990). 682 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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