| Project/Area Number |
02670460
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Kitasato University School of Medicine |
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Principal Investigator |
HIRAISHI Satoshi Kitasato University, Medicine, Associate Professor, 医学部, 助教授 (80118835)
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| Co-Investigator(Kenkyū-buntansha) |
AGATA Youtaro Kitasato University Assistant Professor, 医学部, 講師 (80146430)
YASHIRO Kimio Kitasato University Professor, 医学部, 教授 (60050324)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Newborn infants / Foramen ovale / Left ventricular output / Persistent fetal circulation / 胎児循環遺残 / 筋性中隔欠損 / 新生児循環 / 短絡様式 / 房室弁逆流 / 半月弁逆流 |
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| Research Abstract |
1. Interatrial shunt flow profiles were examined in 36 normal term infants using Doppler echocardiography. Shunt flow across the foramen ovale was detected in 33 infants within an hour of birth. The direction was predominantly left to right, but in 64% there was a coexistent small right to left shunt in diastole. In the six patients with persistent fetal circulation the direction was right to left with biphasic peaks in diastle and systole. The left to right shunt pattern was associated with improvement of the disease. The Doppler method can be useful in assessment of interatrial shunting.
2. We measured left ventricular (LV) output in 34 normal term infants 24 hours before parturition and thereafter serially 1, 24, 96 hours after birth. There was a twofold increase in LV output 1 hour after birth which was associated with significant increases in LV dimension and LV contraction. Heart rate did not change 1 hour after birth. During the subse hours birth, LV output decreased significantly at 24 and 96 hours, which was associated with declines in heart rate and LV dimension. Our data indicate that the major regulator of LV output may be the Frank-Starling mechanism.
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