DEVELOPMENT OF EARLY DETECTION OF LYMPH NODE METASTASIS USING HIGH MOLECULAR IODINATED COMPOUND.
| Project/Area Number |
02670498
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | KOBE UNIVERSITY |
|---|
Principal Investigator |
SAKO Masao KOBE UNIV., SCHOOL OF MED., ASSOCI.PROF, 助教授 (60030970)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KITAGAKI Hajime KOBE UNIV., SCHOOL OF MED., ASSISTANT, 助手 (10234238)
HIROTA Shozo KOBE UNIV., SCHOOL OF MED., LECTURER, 講師 (20181216)
長江 利幸 神戸大学, 医学部,附属病院, 助手 (20227987)
土師 守 神戸大学, 医学部附属病院, 助手 (10198707)
|
|---|
| Project Period (FY) |
1990 – 1992
|
| Project Status |
Completed (Fiscal Year 1992)
|
| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
|
|---|
| Keywords | Lymphography / Indirect Lymphography / Lymph node metastasis / Maculomolecular iodinated compound / Iodinated starch / High resolution CT / 間接リンパ造影法 / 高分子型造影剤 / CT |
|---|
| Research Abstract |
Experimental studies of indirect lymphography was performed for an opacification of regional lymph nodes of organs using iodinated starch containing 20% of iodine. Sixty percent solution of this material was injected into the subcutaneous tissue of pedal area and submucosal layer of the rectum of dogs resulting in a homogeneous opacification of popliteal and perirectal lymph nodes on CT images. Injections of the solution into the testis or the liver showed an opacification of lumbar lymph nodes and periportal hepatic lymph nodes on CT images.
Different molecular weights iodinated starch was prepared and examined optimal molecular weight for indirect lymphography. The results suggested the molecular weight for this purpose would be between 5,000 and 70,000 mol.wt.
Diagnostic ability of this method was examined using a phantom of lymph node metastasis for CT and obtained an excellent result of being able to detect 3mm metastasis in the lymph nodes.
|
Report
(4 results)
Research Products
(12 results)
