• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

DEVELOPMENT OF EARLY DETECTION OF LYMPH NODE METASTASIS USING HIGH MOLECULAR IODINATED COMPOUND.

Research Project

Project/Area Number 02670498
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKOBE UNIVERSITY

Principal Investigator

SAKO Masao  KOBE UNIV., SCHOOL OF MED., ASSOCI.PROF, 助教授 (60030970)

Co-Investigator(Kenkyū-buntansha) KITAGAKI Hajime  KOBE UNIV., SCHOOL OF MED., ASSISTANT, 助手 (10234238)
HIROTA Shozo  KOBE UNIV., SCHOOL OF MED., LECTURER, 講師 (20181216)
長江 利幸  神戸大学, 医学部,附属病院, 助手 (20227987)
土師 守  神戸大学, 医学部附属病院, 助手 (10198707)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
KeywordsLymphography / Indirect Lymphography / Lymph node metastasis / Maculomolecular iodinated compound / Iodinated starch / High resolution CT / 間接リンパ造影法 / 高分子型造影剤 / CT
Research Abstract

Experimental studies of indirect lymphography was performed for an opacification of regional lymph nodes of organs using iodinated starch containing 20% of iodine. Sixty percent solution of this material was injected into the subcutaneous tissue of pedal area and submucosal layer of the rectum of dogs resulting in a homogeneous opacification of popliteal and perirectal lymph nodes on CT images. Injections of the solution into the testis or the liver showed an opacification of lumbar lymph nodes and periportal hepatic lymph nodes on CT images.
Different molecular weights iodinated starch was prepared and examined optimal molecular weight for indirect lymphography. The results suggested the molecular weight for this purpose would be between 5,000 and 70,000 mol.wt.
Diagnostic ability of this method was examined using a phantom of lymph node metastasis for CT and obtained an excellent result of being able to detect 3mm metastasis in the lymph nodes.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 佐古 正雄: "高分子型造影剤を用いたリンパ節転移の早期診断法の開発" INNERVISION. 6. 29-30 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 佐古 正雄: "ヨード化澱粉を用いた間接リンパ造影の実験的研究" 日本医放会誌. 52. 1689-1691 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Masao SAKO,(H.KATAYAMA,RC.Brash ed.): "New Dimension of Comtrast Media" Excerpta Medica International Congress Series 976, 385 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sako,M., et al: "Basic research on iodinated starch as a potential contrast material for blood-pool opacification of tissue and for indirect lymphography." New Dimension of Contrast Media, International Congress(Excerpta Medica). Series 976. 24-28 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sako,M., et al: "Experimental studies of indirect lymphography with iodinated starch." NIPPON ACTA RADIOLOGICA. 52, 12. 1689-1691 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 佐古 正雄: "高分子型造影剤を用いたリンパ節転移の早期診断法の開発" INNERVISION. 6. 29-30 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 佐古 正雄: "ヨード化澱粉を用いた間接リンパ造影の実験的研究" 日本医放会誌. 52. 1689-1691 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Masao Sako,(H,Katayama,RC.Brash ed.): "New Dimension of Contrast Media" Excerpta Medica International Congress Series 976, 385 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 佐古 正雄: "高分子型造影剤を用いたリンパ節転移の早期診断法の開発" INNERVISION. 6. 29-30 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hitoshi Katayama: "New Dimensins of Contrast Media" Excerpta Medica, 385 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Masao Sako,Shozo Hirota,Mamoru Hase et al.: "Basic Research of Iodinated Starch as a Potential Contrast Material for Bloodーpool Opacification of Tissue and for Indirect Lymphography" Proceedings of International Symposium of Contrast Media,Osaka. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 佐古 正雄,廣田 省三,長江 利幸: "高分子型造影剤を用いたリンパ節転移の早期診断法の開発" INNERVISION. (1991)

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi