| Project/Area Number |
02670500
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyushu University |
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Principal Investigator |
ICHIYA Yuichi Kyushu University Faculty of Medicine, Lecturer, 医学部, 講師 (00117425)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Masayuki Kyushu University Faculty of Medicine, Resident, 医学部, 医員
FUKUMURA Toshimitsu Kyushu University Faculty of Medicine, Assistant, 医学部, 助手 (90199266)
OTSUKA Makoto Kyushu University Faculty of Medicine, Assistant, 医学部, 助手 (60203840)
KUWABARA Yasuo Kyushu University Faculty of Medicine, Assistant, 医学部, 助手 (30150436)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1990: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | F-18 fluorodeoxyglucose / Tumor metabolism / Glucose Metabolism / Positron CT |
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| Research Abstract |
In order to evaluate the role of measurement of metabolic alteration of the tumors in the assessment of therapeutic effects, positron emission tomography (PET) using F-18 2-fluoro-2-deoxy-D-glucose (FDG) (FDG-PET) were performed before and/or after therapy in 90 patients with malignant tumors including bronchogenic carcinomas, hepatomas, thyroid cancers and mediastinal tumors. The change in FDG uptake by therapy was compared, with the change of the tumor size. In this series, all malignant lesions had high FDG uptake before therapy. The lesions which had relatively low FDG uptake before therapy did not respond to the therapy. Decreased FDG uptake after therapy was more prominent in the responded group than in the non-responded group. Some of the patients with a decreased FDG uptake after therapy, though tumor sizes did not decreased, had no recurrence. This indicates the possibility of FDG assessing the therapeutic effects in the no change group. A decrease of FDG uptake after therapy did not necessarily indicate a good prognosis, and change of FDG uptake had no value in predicting the prognosis. These results suggest a complementary role of FDG-PET in the assessment of therapeutic effect. We also measured tumor blood flow preliminarily in five patients with malignant tumors using 0-15 water and PET. However, no correlation was noted between tumor blood flow and therapeutic response.
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