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Changes in functions of intermediate filaments in alzhaimer cell

Research Project

Project/Area Number 02670515
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

TAKEDA Masatoshi  Osaka University Medical School Assistant Professor, 医学部, 講師 (00179649)

Co-Investigator(Kenkyū-buntansha) TADA Kunitoshi  Osaka University Medical School Assistant Professor, 医学部, 講師 (80135681)
HARIGUCHI Shiro  Osaka University Medical School Associate Professor, 医学部, 助教授 (10028459)
NISHIMURA Tsuyoshi  Osaka University Medical School Professor, 医学部, 教授 (70028455)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1990: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsAlzheimer's Disease / fibroblast / vimentin / fodrin / intermediate Filament / calcium / protease / ubiquitin / 中間径線維 / ユピキチン / 家族性 / 細胞骨格蛋白 / 皮膚
Research Abstract

The fibroblasts were cultured from the cutaneous tissue of patients with familial Alzheimer's disease and non-familial Alzheimer's disease. In the process of collecting many clones of fibroblasts, a clone with a mutation in amyloid beta-protein precursor gene was found. The mutation was the same as reported by Goat et al, i. e. a substitution of Val to Ile at 717 of amyloid beta-protein precursor. The distribution of vimentin fibers in the cultured fibroblasts were studied, showing the drastic derangement in vimentin distribution in Alzheimer cells. The derangement was most obviously noticed with the cells with the mutation. The vimentin molecule showed no changes but the fodrin showed the increased accumulation in fibroblasts from Alzheimer patients. It was found that fodrin degradation in Alzheimr cells is inhibited. Considering the possibility that fodrin is degraded by Calcium-activated neutral protease (CANP), the calcium level and mobilization in Alzheimer cells was investigated. The results showed that calcium mobilization is significantly suppressed in Alzheimer fibroblasts. It is highly speculated that metabolism of cytoskeletal proteins such as fodrin is altered in Alzheimer cells which is closely related with the pathological processes observed in Alzheimer brain.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] M.Takeda,T.Nishimura,T.Kudo,S.Tanimukai,K.Tada: "Buffy coat from families of Alzheimer's disease patients produces intracytoplasmic neurofilament accumulation in hamster brain" Brain Research. 551. 319-321 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.takeda,T.Nishimura,T.Kudo,S.Tanimukai,T.Gotow,H.Tanabe,T.Miki,Y.Nakamura,H.Niigawa,H.Morita,T.Tanaka,Y.Tatebayashi,K.Tada: "Characterization of intracytoplasmic neurofilament accumulation in hamster brain caused by Alzheimer buffy coat inoculation-in comparison with experimental neurofibrillary changes produced by aluminum intoxication-" Gerontology. 37(suppl 1). 31-42 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Takeda,T.Nishimura,K.Tada,T.Kudo,S.Tanimukai: "Inoculation study of Alzheimer buffy coat into hamster brain--mmunohistochemical characterization of intracytoplasmic neurofilament accumulation in neurons of the lower brain stem nuclei-" Dementia. 2. 57-63 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y.Nakamura,M.Takeda,H.Suzuki,H.Hattori,K.Tada,S.Hariguchi,S.Hashimoto,T.Nishimura: "Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease" Neuroscience Letters. 130. 195-198 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Takeda,Y.Tatebayashi,S.Tanimukai,Y.Nakamura,T.Tanaka,T.Nishimura: "Immunohistological Study of Microtubule-associated Protein 2 and Ubiquitin in Chronically Aluminum-intoxicated Rabbit brain" Acta Neuropathologica. 82. 346-352 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Takeda,T.Nishimura,Y.Tatebayashi,T.Tanaka,S.Tanimukai,K.Tada: "Study of cytoskeletal proteins in cultured fibroblast of Alzheimer's disease" Acta Neurologica Scandinavica. 84. 416-420 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 西村 健,武田 雅俊ほか: "国際基礎神経科学ワ-クショップ" ライフサイエンス出版, 50 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Takeda, T. Nishimura, T. Kudo, S. Tanimukai, K. Tada: "Buffy coat from families of Alzheimer's disease patients produces intracytoplasmic neurofilament accumulation in hamster brain" Brain Research. 551. 319-321 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Takeda, T. Nishimura, T. Kudo, S. Tanimukai, T. Gotow, H. Tanabe, T. Miki, Y. Nakamura, H. Niigawa, H. Morita, T. Tanaka, Y. Tatebayashi: "Characterization of intracytoplasmic neurofilament accumulation in hamster brain caused by Alzheimer buffy coat inoculation -in comparison with experimental neurofibrillary changes produced by aluminum intoxication-" Gerontology. 37(suppl 1). 31-42 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Takeda, T. Nishimura, K. Tada, T. Kudo, S. Tanimukai: "Inoculation study of Alzheimer buffy coat into hamster brain -immunohistochemical characterization of intracytoplasmic neurofilament accumulation in neurons of the lower brain stem nuclei-" Dementia. 2. 57-63 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y. Nakamura, M. Takeda, H. Suzuki, H. Hattori, K. Tada, S. Hariguchi, S. Hashimoto, T. Nishimura: "Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease" Neuroscience Letters. 130. 195-198 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Takeda, Y. Tatebayashi, S. Tanimukai, Y. Nakamura, T. Tanaka, T. Nishimura: "Immunohistological Study of Microtubule-associated Protein 2 and Ubiquitin in Chronicaly Aluminum-intoxicated Rabbit brain" Acta Neuropathologica. 82. 346-352 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Takeda, T. Nishimura, Y. Tatebayashi, T. Tanaka, S. Tanimukai, K. Tada: "Study of cytoskeletal proteins in cultured fibroblast of Alzheimer's disease" Acta Neurologica Scandinavica. 84. 416-420 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Yoshimi, M. Takeda, T. Nishimura, T. Kudo, Y. Nakamura, K. Tada, N. Iwata: "An immunohistochemical study of MAP2 and clathrin in gerbil hippocampus after cerebral ischemia" Brain Research. 560. 149-158 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y. Nakamura, M. Takeda, K. J. Angelides, K. Tada, S. Hariguchi, T. Nichimura: "Assembly, disassembly, and exchange of glial fibrillary acidic protein" CLIA. 4. 101-110 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Nakamura, M. Takeda, Y. Kato, T. Tanaka, J. Tanaka, K. Nishinuma, T. Nishimura: "Glial Fibrillary Acidic Protein stimulates Lymphocyte proliferation and immunoglobulin synthesis of Alzheimer's disease patients" Meth and Find Exp Clin Pharmacol. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Takeda, T. Nishimura, T. Kudo, S. Tanimukai, T. Tatebayashi, M. Okochi, A. Sekiyama, T. Kurumadani, S. Hariguchi: "Transmission study of neurofilament pathology in hamster brain produced by Alzheimer buffy coat inoculation" The Treatment of Dementia : A New Generation of Progress. Plenum Press. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M. Takeda, T. Nishimura: "Changes in cytoskeletal system in fibroblasts from patients with familial Alzheimer's disease" Prog Neuropsychopharmacol & Biol Psychiat. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Takeda,T.Nishimura,T.Kudo,S.Tanimukai,K.Tada: "Buffy coat from families of Alzheimer's disease patients produces intracytoplasmic neurofilament accumulation in hamster brain" Brain Research 551:319ー321,1991. 551. 319-321 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Takeda,T.Nishimura,T.Kudo,S.Tanimukai,T.Gotow,H.Tanabe,T.Miki,Y.Nakamura,H.Niigawa,H.Morita,T.Tanaka,Y.Tatebayashi,K.Tada: "Characterization of intracytoplasmic neurofilament accumulation in hamster brain caused by Alzheimer buffy coat inoculationーin comparison with experimental neurofibrillary changes produced by aluminum intoxicationー" Gerontology 37(suppl 1,31ー42,1991.37. 31-42 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Takeda,T.Nishimura,K.Tada,T.Kudo,S.Tanimukai: "Inoculation study of Alzheimer buffy coat into hamster brainーimmunohistochemical characterization of intracytoplasmic neurofilament accumulation in neurons of the lower brain stem nucleiー" Dementia 2:57ー63,1991.2. 57-63 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Y.Nakamura,M.Takeda,H.Suzuki,H.Hattori,K.Tada,S.Hariguchi,S.Hashimoto,T.Nishimura: "Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease" Neuroscience Letters 130,195ー198,1991. 130. 195-198 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Takeda,Y.Tatebayashi,S.Tanimukai,Y.Nakamura,T.Tanaka,T.Nishimura: "Immunohistological Study of Microtubuleーassociated Protein 2 and Ubiquitin in Chronically Aluminumーintoxicated Rabbit brain" Acta Neuropathologica 82,346ー352,1991. 82. 346-352 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Takeda,T.Nishimura,Y.Tatebayashi,T.Tanaka,S.Tanimukai,K.Tada: "Study of cytoskeletal proteins in cultured fibroblast of Alzheimer's disease" Acta Neurologica Scandinavica 84,416ー420,1991.84. 416-420 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 西村 健,武田 雅俊、ほか: "国際基礎神経科学ワ-クショップ" ライフサイエンス出版, 50 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Takeda,M.Tanaka,T.Kudo,Y.Nakamura,K.Tada,T.Nishimura: "Changes in Attaching Efficacy and Cytoskeletal Proteins in the Fibroblasts from Alzheimer's Disease Patients" Jpn J Psychopharmacology. 11. 99 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Nishimura,M.Takeda: "Cytoskeletal Aberration in Alzheimer's Disease Fibroblasts" Clin Neuropharmacology. 13. 416-417 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Takeda,M.Tanaka,T.Kudo,Y.Nakamura,K.Tada,T.Nishimura: "Changes in Adhesion Efficiency and Vimentin Distribution of Fibroblasts from Familial Alzheimer's Disease" Acta Neurologica Scandinavica. 82. 238-244 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Takeda,T.Nishimura,T.Kudo,S.Tanimukai,K.Tada: "Buffy Coat from Families of Alzheimer's Disease Patients Produces Intracytoplasmic Neurofilament Accumulation in Hamster Brain" Brain Research.

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Takeda,T.Nishimura,Y.Tatebayashi,T.Tanaka,S.Tanimukai,K.Tada: "Study of Cytoskeletal Proteins in Cultured Fibroblasts from Alzheimer's Disease" Acta Neurologica Scandinavica.

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Takeda,T.Nishimura,K.Tada,T.Kudo,S.Tanimukai: "Inoculation Study of Alzheimer Buffy Coat into Hamster BrainーImmunohistochemical Characterization of Intracytoplasmic Neurofilament Accumulation in Neurons of the Lower Brain Stem Nucleiー" Dementia.

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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