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Involvement of reactive oxygen species in flap necrosis and development of its prevention by antioxidants.

Research Project

Project/Area Number 02670542
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SUZUKI Shigehiko  Faculty of Med. Plastic Surgery Assist. Professor, 医学部, 助教授 (30187728)

Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsSOD / Reactive oxygen species / Skin flap / Antioxidant / Lipid peroxide / Fat flap / 過酸化脂貿 / 虚血再潅流障害
Research Abstract

1)In attempts to substantiate the possible participation of reactive oxygen species, and significance of the xanthine oxidase system in both post-ischemic reperfusion necrosis of the island flap and distal necrosis of the pedicle flap, and to develop new pharmacological measures for salvaging flap necrosis, a series of experiments were made using an island flap model and a random-pattern flap model in rats. The results demonstrated a possible involvement of ROS in both post-ischemic necrosis of island flaps and distal necrosis of random flaps. Xanthine oxidase was significant in producing ROS only in the former.
2)In order to examine the effect of topical use of SOD ointment which contains 1% SOD on the enhancement of flap survival, three experiments were made. Its application to the under surface of the flap or occlusive dressing was effective.
3)Involvement of lipid peroxidation in flap necrosis and effect of topical application of herbal antioxidant in salvagng flap necrosis were investigated. Among the herbal antioxidants, ellagic acid exerted the strongest effect in suppressing lipid peroxide levels and increasing flap survival.
4)Ischemic-reperfusion injury of island fat flap of rats was also investigated.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 鈴木 茂彦,宮地 良樹,浜中 宏,吉岡 伸高: "虚血後の皮弁壊死メカニズムの解明ならびに壊死救済に関する実験的研究" 日本リデイアオリリー協会元年度年報. 13. 123-126 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 浜中 宏,宮地 良樹,今村 貞夫,鈴木 茂彦,吉岡 伸高: "虚血再灌障害による皮弁壊死モでるにおける Superoxide Dismutase(SOD) 活性の検討" 皮膚科叫要. 85. 25-28 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 鈴木 茂彦,吉岡 伸高,一色 信彦,宮地 良樹,浜中 宏: "筋肉,皮膚の虚血再灌流障害と組織内SOD活性植について" 日本手の外科学会誌. 7. 212-215 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SUZUKI.S. YOSHIOKA.N. ISSHIKI.N HAMANAKA.H and MIYACHI.Y: "Involvement ofreative oxygen species in postischemec flap necrosis and its prevention by antioxidants." British Journal of Plastic Surgery. 44. 130-134 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SUZUKI.S. MATSUSHITA.Y. ISSHIKI.N. HAMANAKA.H and MIYACHI.Y.: "Salvage of distal flap necrosis by topical superoxide desmutase" Annals of Plastic Surgery. 27. 253-257 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 鈴木 茂彦,一色 信彦,浜中 宏,宮地 良樹: "皮膚虚血-再灌流と活性酸素・フリーラジカル" 活性酸素・フリーラジカル. 3. 298-305 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 鈴木 茂彦: "皮弁壊死の予防と対策:皮弁移植法,最近の進歩・鳥居修平編" 克誠堂出版,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Suzuki, S., Yoshioka, N., Isshiki, N., Hamanaka, H. and Miyachi, Y.: "Involvement of reactive oxygen species in postischemic flap necrosis and its prevention by antioxidants." Br. J. Plast. Surg.44. 130-134 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Suzuki, S., Matsushita, Y., Isshiki, N., Hamanaka, H. and Miyachi,Y.: "Salvage of distal flap necrosis by topical superoxide dismutase, Ann." Plast. Surg.27. 253-257 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 鈴木 茂彦,一色 信彦,浜中 宏,宮地 良樹: "皮膚虚血-再潅流と活性酸素・フリーラジカル." 活性酸素・フリーラジカル. 3. 298-305 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 大塚 守正,鈴木 茂彦,一色 信彦: "レーザードップラー組織血流計,熱勾配式組織血流計を用いた皮弁血流測定及び臨床応用について." 日本形成外科学会誌.

    • Related Report
      1992 Annual Research Report
  • [Publications] 鈴木 茂彦: "皮弁壊死の予防と対策:皮弁移植法,最近の進歩. 鳥居 修平編" 克誠堂出版,

    • Related Report
      1992 Annual Research Report
  • [Publications] Suzuki,S.: "Involvement of reactive oxygen species in postischemic flap necrosis and its prevention by antioxidants" British Journal of Plastic Surgery. 44. 130-134 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Suzuki,S.: "Salvage of distal flap necrosis by topical superoxide dismutase" Annals of Plastic Surgery. 27. 253-257 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Suzuki,S.: "Involvement of reactive oxygen species in postischemic flap necrosis and its prevention" Procceding of the 7th International Conference of Plastic Surgery.

    • Related Report
      1991 Annual Research Report
  • [Publications] 鈴木 茂彦: "皮膚虚血ー再潅流と活性酸素,フリ-ラジカル." 活性酸素,フリ-ラジカル.

    • Related Report
      1991 Annual Research Report
  • [Publications] 鈴木 茂彦: "皮弁壊死の予防と対策:皮弁移植法.最近の進歩.鳥居修平編" 京誠堂出版,

    • Related Report
      1991 Annual Research Report
  • [Publications] Suzuki,S.,Yoshioka,N.,Isshiki,N.,Hamanaka,H.and Miyachi,Y.: "Involvement of reactive oxygen species in postischemic flap necrosis and its prevention by antioxidants." British Journal of Plastic Surgery.

    • Related Report
      1990 Annual Research Report
  • [Publications] Suzuki,S.,Matsushita,Y.,Isshiki,N.,Hamanaka,H.and Miyachi,Y.: "Salvage of distal flap necrosis by topical superoxide dismutase (SOD)." Annals of Plastic Surgery.

    • Related Report
      1990 Annual Research Report
  • [Publications] Suzuki,S.,Matsushita,Y.,Isshiki,N.,Hamanaka,H.and Miyachi,Y.: "Involvement of reactive oxygen species in postischemic flap necrosis and its prevention." Proceeding of the 7th International Congerence of Plastic Surgery.

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 茂彦: "皮弁壊死の予防と対策:皮弁移植法,最近の進歩 鳥居 修平編" 克誠堂出版, (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2021-12-20  

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