| Project/Area Number |
02670555
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Saitama Medical School |
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Principal Investigator |
MAEDA Hiroo Saitama Medical School, Faculty of Medicine, Associated Professor, 医学部, 助教授 (30134597)
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| Co-Investigator(Kenkyū-buntansha) |
HITOMI Yuko Saitama Medical School, Faculty of Medicine, Assistant Professor, 医学部, 助手 (80181105)
TOHYAMA Hiroshi Saitama Medical School, Faculty of Medicine, Professor, 医学部, 教授 (00008278)
池淵 研二 埼玉医科大学, 医学部, 講師 (20175194)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1991: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1990: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Autologous blood transfusion / Recombinant human erythropoietin / Post-transfusion hepatitis |
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| Research Abstract |
To avoid the side effects by homologous blood transfusion, we conducted predeposit autologous blood transfusion in patients undergoing orthopedic surgery with or without use of recombinant human erythropoietin (rHu-EPO). The patients not given rHu-EPO donated 400 ml of blood weekly for 3 weeks, a total of 1, 200 ml, before operation, unless the hemoglobin (Hb) value was less than 11.0 g/dl (the control group). In the same protocol, the patients given rHu-EPO (Chugai Pharmaceutical, Tokyo) twice or thrice a week for 4 weeks before operation also donated 1, 200 ml of autologous blood (the EPO 2/W and EPO 3/W groups). Ten of 12 patients in the control group succeeded in donating 1, 200 ml of blood, but the Hb value of 13.8 g/dl at predonation dropped to 10.9 g/dl after 1, 200 ml donation. All patients in the EPO group donated 1, 200 ml of blood and the Hb values of 13.0 g/dl and 12.7 g/dl in the EPO 2/W and 3/W groups at predonation only slightly decreased to 12.0 g/dl and 12.0 g/dl after donation, respectively. The decreased Hb value of 2.9 g/dl in the control group was significantly greater than those of the EPO group (1.0 g/dl in the EPO 2/W and 0.7 g/dl in the EPO 3/W group). The postoperative nadir of the Hb value in the control group was 8.0 g/dl and three patients in the control required homologous transfusion. The nadir of the Hb values in the EPO 2/W and 3/W group was 9.2 and 10.0 g/dl, respectively and none required homologous blood transfusion. rHu-EPO was efficacious in preventing the donor/patients from anemia induced by donations and useful in avoiding homologous blood transfusion.
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