| Project/Area Number |
02670567
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MISHIMA Yoshio Tokyo Medical & Dental Univ., 医学部, 教授 (00010158)
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| Co-Investigator(Kenkyū-buntansha) |
山崎 拓造 東京医科歯科大学, 医学部, 医員
石田 秀行 東京医科歯科大学, 医学部, 医員
IWAMA T. Tokyo Medical & Dental Univ., 医学部, 助教授 (70114741)
YAMAZAKI T. Tokyo Medical & Dental Univ.
ISHIDA H. Tokyo Medical & Dental Univ.
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1990: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | portal vein / infusion therapy / hepatic metastasis / chemotherapy / experimental study / 治療効果 / BrdU / ハイドロキシアパタイト / 徐法性抗癌剤 / アドリアマイシン / 転移性肝癌 / 微小癌 / 門脈 / 化学療法 / 叙放製剤 / 5ーFU / Adriamycin / アパタイトセラミックス |
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| Research Abstract |
This study was conducted to clarify the role of continuous portal infusion (CPI) for preventing liver metastasis.
1) Male Donryu rats(180g) receiving intraportal inoculation of ascites hepatoma AH60C were divided into 3 groups; portal infusion, venous infusion and control groups. The portal infusion group alone showed a significant decrease hepatic tumor and prolonged survival time. Hetatic NK activities was significantly decreased in the portal infusion group.
2) Hepatic metastasis were generated by intraportal inoculation of AC60C cells(5x10^6) in male Donryu rats. Each of the treated animals 5-FU or adriamycin via either portal vein or hepatic artery. Both 5FU and adriamycin therapy demonstrated similar results: Portal vein chemotherapy was effective only at the early metastatic phase. In contrast, hepatic artery chemotherapy was significantly effective irrespective of the time of initiation of treatment. Our results would be of help in clinical management of occult liver metastasis.
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