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Basic Research on Hormonal Treatment of Pancreatic Cancer

Research Project

Project/Area Number 02670595
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionNippon Medical School

Principal Investigator

UCHIDA Eiji  Nippon Medical School, Department of Medicine, Assistant, 医学部・第一外科, 助手 (70176684)

Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1991: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
KeywordsPancreatic cancer / Sex hormone / Biological character / Oncogene / 膵蔵癌 / エストロゲン
Research Abstract

1. Studies on estradiol (E2) and estrogen receptor (ER) in human pancreatic tissues. E2-positive cells were immunohistochemically found in 17 of 22 cases. ER was almost negative. Biochemical assay of ER in frozen tissue was negative.
2. Immunohistochemical expressions of epidermal growth factor (EGF), epidermal growth factor receptors and c-erbB-2 oncoprotein in human pancreatic cancer. The positive rates of EGF, EGFR and the c-erbB-2 oncoprotein in pancreatic cncer tissues were 72%, 36% and 28%, respectively. The survival period for patients who tested positive for these three proteins was statisticaly shorter than for those who tested negative.
3. The proliferating potential of human pancreatic cancer cells were studied by Ag-Nucleolar Organizer Regions (NORS) staining. A significant difference in Ag-NORs index was found between benign (normal : 1.86<plus-minus>0.38, pancreatitis : 2.14<plus-minus>0.53) and malignant (4.02<plus-minus>1.19) tissues of pancreas(p<0.01). Ag-NORs index in pancreatic carcinoma showed significantly lower value than that in cancer of stomach (6.35<plus-minus>1.32) and colon (7.66<plus-mi
4. The Wistar Bonn/ Kobori rat (WBN/Kob) that is induced pancreatitis and diabetes mellitus spontaneously was studied for the carcinogenesis. Azaserine (50 mg/body, ip) did not induce pancreatic cancer in this rat. Inoculation of 7, 12-dimethylbenz(a)anthracene induced the duct cell-like carcinoma in pancreas of this rat as well as conventional Wistar rat.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] 山中 洋一郎他: "ヒト膵臓癌におけるEpidermal Growth FactorおよびEpidermal Growth Factor Receptorに関する免疫組織化学的検討" 日本消化器病学会雑誌. 87. 1544-1550 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 内田 英二他: "膵癌のmyc,cーerbBー遺伝子産物の発現と悪性度" 胆と膵.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 相本 隆幸他: "ヒト膵癌におけるAgーNORs染色からみた腫瘍細胞増殖能の検討" 日本外科学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y. Yamanaka, E. Uchida et al.: "Immunohistochemical study on epidermal growth factor and epidermal growth factor receptor in human pancreatic cancer" Jpn J Gastroenterol. 87. 1544-1550 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] E. Uchida et al.: "Immunohistochemical expressions of myc and c-erbB-2 oncogene product in human pancreatic cancer" Tan to Sui. 13. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T. Aimoto, E. Uchida et al.: "Study on proliferating potential by Ag-NORs staining in human pancreatic carcinoma" Nippon Gekagakkai Zashi. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 内田 英二: "膵癌のmyc.cーerbBー2遺伝子産物の発現と悪性度" 胆と膵. 13. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 相本 隆幸: "ヒト膵癌におけるAgーNORs染色からみた腫瘍細胞増殖能の検討" 日本外科学会雑誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 山中 洋一郎: "ヒト膵蔵癌におけるEpidermal Growth FactorおよびEpidermal Growth Factor Receptorに関する免疫組織化学的検討" 日本消化器病学会雑誌. 87. 1544-1550 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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