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Basic and clinical study of spinal instrumentation made of new artificial materials

Research Project

Project/Area Number 02670643
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

SHIRADO Osamu  Hokkaido University Hospital, Instructor, 医学部附属病院, 助手 (20206296)

Co-Investigator(Kenkyū-buntansha) TADANO Shigeru  Hokkaido Univ. Faculty of Engineering, Associate Professor, 工学部, 助教授 (50175444)
KANEDA Kiyoshi  Hokkaido Univ. School of Med. Professor, 医学部, 教授 (60000957)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1992: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1991: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1990: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsspinal instrumentation / artificial materials / biomaterials / trunk muscle / biomechanics / 脊椎個定器具
Research Abstract

Spinal instrumentations, which are made of stainless steel, play a significant role to stabilize the injured spines caused by trauma, tumors, degenerative diseases, and the other disorders. Those instrumentations have allowed patients to ambulate immediately after surgery. Thus, they can enjoy the good quality of life, even after big surgeries. Major disadvantages, however, are as follows; 1) Patients treated with spinal instrumentations (stainless steel) can not be examined with MRI (Magnetic Resonance Imaging), which is very useful in evaluating the neural tissues.:2) Spinal instrumentations, made of stainless steel, sometimes have to be removed two or three years after surgery. The purpose of this study are to evaluate the possibilities of spinal instrumentations, made of new artificial materials and to analyze the biomechanical properties of trunk muscle, which plays a important role after spinal stabilization surgery using spinal instrumentations. Results are as follows;
1) Biocomp … More atible new materials such as chitin, polylactic acid, biodegradable high-molecule polymer, can be used for spinal instrumentations. Mechanical strength of the above materials, however, is inadequate for clinical use as spinal instrumentations. Stronger bioactive materials are now being evaluated.
2) From our clinical studies, spinal instrumentation made of titanium is now one of the best biocompatible ones for clinical use.
3) Trunk muscle strength is weaker in the patients with various spinal disorders than in the healthy subjects. This was true in the trunk muscle endurance. New methods for examining trunk muscle endurance are developed, modified with Kraus-Weber test and Sorensen test. Moreover, patients have the weaker trunk muscles in terms of both concentric and eccentric contraction. Trunk muscle proved to be quite important tissue for stabilize the spinal column as dynamic stabilizer.
4) Characteristics of flexion-relaxation phenomenon became clear. This phenomenon occurred only in patients with low-back pain.
5) On the next step, newer materials for spinal instrumentations and characteristic of trunk muscle have to be more analyzed. Less

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (40 results)

All Other

All Publications (40 results)

  • [Publications] 白土 修: "脊椎分離・すべり症に対するinstrument使用の必要性、厳密な適応、禁忌" Monthly Book Orthopaedisc. 6. 115-124 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu SHIRADO: "Quantitative Histologic Study of the lnfluence of Anterior spinal lnstrumentation and Biodegradable Polymer on Lumbar Fusion After Corpectomy-A Canine Model." Spine. 17(7). 795-803 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu SHIRADO: "Influence of Disc Degeneration on Mechanism of Thoracolumbar Burst Fractures." Spine. 17(3). 286-292 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu SHIRADO: "Trunk-Muscle Strength During Cocentric and Eccentric Contraction:Acomparison Between Healthy Subjects and Patients with Chronic Low-Back Pain." J.of Spinal Disorders. 5(2). 175-182 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu SHIRADO: "Trunk-Muscle Strength during Eccentric Contraction in Patients with Chronic Low-Back Pain." Orthop.Trans.(1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu SHIRADO: "Biomechanical Evaluation of Methods of Posterior Stabilization of the Spine and Posterior Lumbar lnterbody Arthorodesis for Lumbosacral lsthmic Spondylolisthesis.A calf-Spine Model." J.B.J.S. 73(A). 518-526 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 白土 修: "In vivo animal modelを用いたspinal instrumentationの実験的研究." 別冊整形外科. 20. 8-11 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 白土 修: "胸・腰椎損傷の分類-Clinical biomechanicsと神経障害からinstrumentation手術適応の検討" OS NOW. 4. 40-51 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 白土 修: "体幹筋力に関する基礎的研究-特に収縮様式に着目して-" 整形外科バイオメカニクス. 12. 183-187 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 白土 修: "脊椎分離・すべり症に対するInstrument使用の必要性、厳密な適応、禁忌" Monthly Book Orthopaedisc. 6. 115-124 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 白土 修: "生検を用いた椎体切除後における脊柱前方固定術のX線学的および生体力学的研究" 整形外科バイオメカニクス. 11. 25-29 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Spinal instrumentation for isthmic spondylolisthesis(in Japanese)" Monthly Book Orthopaedics. 6. 115-124 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Quantitative Histologic Study of the Influence of Anterior spinal Instrumentation and Biodegradable Polymer on Lumbar Interobody Fusion After Corpectomy-A Canine Model." Spine. 17(7). 795-803 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Influence of Disc Degeneration on Mechanism of Thoracolumbar Burst Fractures." Spine. (17)3. 286-292 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Trunk-Muscle Strength During Cocentric and Eccentric Contraction: A comparison Between Healthy Subjects and Patients with Chronic Low-Back Pain." J. of Spinal Disorders. 5(2). 175-182 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Trunk Muscle Strength during Eccentric contraction in Patients with Choronic Low Back Pain." Orthop. Trans.(1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Biomechanical Evaluation of Methods of Posterior Stabilization of the Spine and Posterior Lumbar Interbody Arthorodesis for Lumbosacral Isthmic Spondylolisthesis. A call-Spine Model." J.B.J.S. 73(A). 518-526 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Treatment of isthmic spondylolisthesis with nerve root decompression and posterolateral fusion using Steffee transpedicular screw system.(in Japanese)" Bessatu Seikeigeka. 20. 127-130 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Experimental study of spinal instrumentation using in vivo animal model(in Japanese)" Bessatu Seikeigeka. 20. 8-11 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Classification of thoracolumbar spinal injuries(in Japanese)" OS NOW. 4. 40-51 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "The study of trunk muscle strength based on contraction modes(in Japanese)" Orthopedic Biomechanics. 12. 183-187 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Radiographic and biomechanical study of anterior spinal reconstructive surgery following corpectomy in canine model.(in Japanese)" Orthopedic Biomechanics. 11. 25-29 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Osamu Shirado: "Quantitative Histologic Study of the Influence of Anterior Spinal Instrumentation and Biodegradable Polymer on Lumbar Interbody Fusion after Corpectomy-A canine model-" Spine. 17(7). 795-803 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Osamu Shirado: "Influence of disc degeneration on mechanism of thracolumbar burst fractures" Spine. 17(3). 286-292 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Osamu Shirado: "Trunk Muscle Strength During Concentric and Eccentric Contracrion:A Compatison Between Healthy Subjects and Patients with Chronic Low-Back Pain" Journal of Spinal Disorders. 5(2). 175-182 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Osamu Shirado: "Trunk Muscle Strength during Eccentric Contraction in Patients with Chronic Low Back Pain" Orthop Trans. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 白土 修: "腰椎分離・辷り症に対するInstrument使用の必要性、厳密な適応、禁忌" M B Orthop.6(1). 115-124 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 白土 修: "腰椎疾患に対するflexible stabilization ーGraf systemの紹介と短期成績ー" 東日本臨整会誌. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 白土 修: "急性期脊椎脊髄損傷ー胸椎・腰椎ー 脊椎脊髄損傷の治療" 現代医療社, (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 金田 清志: "骨折の治療法ー寝たきりにさせないためにー 脊椎 骨粗鬆症による寝たきり防止マニュアル" (財)骨粗鬆症財団, (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Osamu Shirado,et al.: "Trunk Muscle Strength during Concentric and Eccentric Contraction" J.Spinal Disord. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kiyoshi Kaneda,Osamu Shirado,et al: "New Entity of Thoracoーlumbar Spinal Injuries;Is that flexionーdistraction injury,burst fracture,or combined type?" Orthop.Trans.(1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 白土 修,他:"腰椎分離辷り症に対する神経根除圧とSteffee transpedicular screw systemによる固定術の成績" 別冊整形外科. 20. 127-130 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 白土 修,他:"求心性および遠心性収縮における体幹筋力の基礎的研究" 整形外科バイオメカニクス. 12. 183-187 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 白土 修: "体幹筋力に関する基礎的研究" 日本理学診療医学会誌. 2. 89-91 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 伊藤 俊一,金田 清志,白土 修 他:"特発性側弯症患者における体幹側方重心移動能に関する研究" 整形外科バイオメカニクス. 12. 417-421 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Osamu Shirado,et al.: "Trunk Muscle Strength during Eccentric Contraction in Patients with Chronic Low Back Pain." Spine.

    • Related Report
      1990 Annual Research Report
  • [Publications] Osamu Shirado,et al.: "Kinetic Analysis of Trunk Shift Performance in Patients with Idiopathic Scoliosis." Spine.

    • Related Report
      1990 Annual Research Report
  • [Publications] 白土 修、他: "求心性および遠心性収縮における体幹筋力の基礎的研究." 整形外科バイオメカニクス.

    • Related Report
      1990 Annual Research Report
  • [Publications] 伊藤 俊一、白土 修、他: "特発性側弯症患者における重心移動能に関する基礎的研究." 整形外科バイオメカニクス.

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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