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Application of High Strength Polylactide Implants for Osteosynthesis

Research Project

Project/Area Number 02670655
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

MATSUSUE Yoshitaka  Kyoto University, Medicine, Assistant Professor, 医学部, 助手 (30209548)

Co-Investigator(Kenkyū-buntansha) IKADA Yoshito  Kyoto University, Research Center for Biomedical Engineering, Professor, 生体医療工学研究センター, 教授 (00025909)
YAMAMURO Takao  Kyoto University, Medicine, Professor, 医学部, 教授 (00088527)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1992: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsBiodegradable / Polymer / Polylactide / Osteosynthesis / Strength / Screw / Plate / 生体的分解性 / スクリュ- / プレ-ト
Research Abstract

To overcome the drawback of the metallic device for fracture repair, ultra-high-strength poly(L-lactide)(PLLA) rods were fabricated using a drawing technique. Rods with a diameter of 3.2 mm and a draw ratio of 2.5 : 1 showed initial bending strength and modulus values of 240 MPa and 13 GPa, respectively, which is the highest reported for nonreinforced poly(L-lactide) rods used in detailed investigations of degradation. The greater the rod diameter, the longer the bending strength was maintained in phosphate buffered saline at 37゚C. The bending strength retention of rods implanted in the subcutis of rabbits was almost equal to that of rods in the in vitro study, while those rods implanted in the medullary cavity of rabbit femora showed a slightly lower bending strength retention. The weight of PLLA rods in the medullary cavity was reduced by 22% at 52 weeks and by 70% at 78 weeks after implantation. Histologically, no foreign body or inflammatory reaction was observed in the medullary cavity for 52 weeks. Phagocytosis by histiocyte was observed after 52 weeks and reached to the maximum level at 2 to 2.5 years after implantation. The another study on the PLLA screw in the repair of fractured rabbit bone showed that there was no significant difference of the fragments in the PLLA and stainless steel group and new bone was more abundantly detected in the PLLA group. These results suggest that the drawn PLLA screws and rods may be useful in the repair of fractured human bones.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Y.Matsusue et.al: "Biodebradable screw fixation of rabbit tibia proximal osteotomies" Journal of Applied Biomaterials. 2. 1-12 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Matsusue et.al: "Im vivo and in vitro studies on ultra-hibh strength poly(L-lacfide)rods." Journal of Biomedical Materials Researel. 26. 1553-1567 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松末 吉隆 ほか: "高強度ポリ乳酸ロッドについて" 日本整形外科会誌. 64. 1285 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松末 吉隆 ほか: "生体内分解性ポリ-l-乳酸スクリュー -in vitro および in vivo の研究-" 日本整形外科学会誌. 65. 1130 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松末 吉隆: "生体内分解性骨接合材料" 医学のあゆみ. 160. 187 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 山室 隆夫 ほか: "生体内吸収性ポリ-L-乳酸骨接合材の臨床成績" 臨床整形外科. 28. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松末 吉隆,山室 隆夫: "整形外科医用材料マニュアル(ポリ-l-乳酸成形体)" 金原出版, 224 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y. Matsusue et al.: "Biodegradable screw Fixation of Rabbit Tibia Proximal Osteotomies" Journal of Applied Biomaterials. Vol.2. 1-12 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y. Matsusue et al.: "Invivo and in vitro studies on Ultra-high strength poly (l-lactide) rods" Journal of Biomedical Materials Research. Vol.26. 1553-1567 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y. Matsusue and T. Yamamuro: "Poly-L-lactide Implants" Orthopaedic Medical Implants. 171-175 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Matsusue et.al: "Biodegradable serew fixation of rabbit tibia proximal osteotomies" Journal of Applied Biomaterials. 2. 1-12 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Matsusue et.al: "In vivo and in vitro studies on ultra-high strength poly (L・lactide)rods." Journal of Biomedical Materials Research. 26. 1553-1567 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 松末 吉隆ほか: "高強度ポリ乳酸ロッドについて" 日本整形外科学会誌. 64. 1285 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 松末 吉隆ほか: "生体内分解性ポリ-l-乳酸スクリュー-in vitro およびin vivoの研究-" 日本整形外科学会誌. 65. 1130 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 松末 吉隆: "生体内分解性骨接分材料" 医学のあゆみ. 160. 187 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 山室 隆夫ほか: "生体内吸収性ポリ-L-乳酸骨接合材の臨床成積" 臨抜床整形外科. 28. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 松末 吉隆,山室 隆夫: "整形外科医用材料マニュアル(ポリ-l-乳酸成形体)" 金原出版, 224 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Matsusue et al: "Biodegradable screw fixation of rabbit tibia proximal osteotomies" Journal of Applied Biomaterials. 2. 1-12 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Y.Matsusue et al: "In vivo and in vitro studies on ultraーhigh strength poly(lーlactide)rods" Journal of Biomedical Materials Research.

    • Related Report
      1991 Annual Research Report
  • [Publications] 松末 吉隆 ほか: "生体内分解性骨螺子を用いた実験的骨接合術" 日本整形外科学会誌. 63. 1230 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松末 吉隆 ほか: "高強度ポリ乳酸ロッドについて" 日本整形外科学会誌. 64. 1285 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松末 吉隆 ほか: "生体内分解性ポリーlー乳酸スクリュ-ーin vitroおよびin vivoの研究ー" 日本整形外科学会誌. 65. 1130 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松末 吉隆: "生体内分解性骨接合材料" 医学のあゆみ. 160. 187 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松末 吉隆,山室 隆夫: "ポリ-Lー乳酸成形体" 金原出版, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 松末 吉隆: "生体内分解性骨螺子を用いた実験的骨接合術" 日本整形外科学会誌. 63. 1230 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 松末 吉隆: "高強度ポリ乳酸ロッドについて" 日本整形外科学会誌. 64. 1285 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Nakamura: "Bioabsorption of polylactides with different molecular properties" Journal of Biomedical Materials Research. 23. 1115-1130 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Matsusue: "Biodegradable srew fixation of rabbit tibia proximal osteotomies" Journal of Applied Biomaterials. 2. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Matsusue: "In vivo and in vitro studies on ultraーhigh strength poly(lーlactide) rods" Journal of Biomedical Materials Research.

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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