| Project/Area Number |
02670656
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Yamaguchi Univ. Dept of Orthop Surg |
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Principal Investigator |
DOI Kazuteru Yamaguchi Univ. School of Med., 医学部, 助教授 (50133153)
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| Project Period (FY) |
1990 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1992: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Allograft / Joint graft / Bone graft / Periosteal graft / Microsurgery / Vascularized / Immunosuppression / Rejection / 免疫抑制剤 / 実験的研究 / 血管柄付き骨骨膜移植 / 関節軟骨 / 硝子軟骨 |
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| Research Abstract |
Examination was made on the effects of Cyclosporine A, an immuno-suppressive drug, on vascularized joint allografts. Generally inbred DA and Lewis rats were used and a model of knee joint orthotopical transplantation across the major histocompatibility barrier was developed. Nine non-immunosuppressive allografts failed to acquire bony union. Twenty-seven short term immunosuppressive rats acquired solid union, but following withdrawal of immunosuppression, the grafts were soon rejected and joint function was lost due to pathological fractures of the grafted bone or joint instability. Thirteen allografts of continuous immunosuppression at a dose of 5 mg/kg/day showed no rejection, though the bone marrow did, and there was no impairment of function. The continuous administration of low and non-toxic dose of Cyclosporine A was necessary for maintaining grafted joint functions.
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