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Metastatic mechanism of bone and soft tissue tumors from the view point of matrix-metalloproteinases

Research Project

Project/Area Number 02670671
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKurume University

Principal Investigator

KOMIYA Setsurou  Dept. of Orthopedics Kurume Med.school Lecturer, 医学部・整形外科, 講師 (30178371)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Sanshiro  Dept. of Orthopedics Kurume Med.school Fellow, 医学部・整形外科, 助手
HIRAOKA Kohji  Dept. of Orthopedics Kurume Med.school Fellow, 医学部・整形外科, 助手
MINAMITANI Kazuhito  Dept. of Orthopedics Kurume Med.school Fellow, 医学部・整形外科, 助手 (80248434)
柿添 光生  久留米大学, 医学部, 助手
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1990: ¥500,000 (Direct Cost: ¥500,000)
KeywordsMetastasis / Bone tumor / Soft part tumor / Basement membrane / Matrix-metalloproteinase / Osteoclast / 骨吸収活性
Research Abstract

Various cell lines derived from bone and soft tissue tumors have been established.
They include 4 osteosarcomas, 2 chondrosarcomas, 4 metastatic bone cancers, 4 malignant fibrous histiocytoma, and 3 giant cell tumor of bones. Cell lines with high potentiality for pulmonary metastasis showed multiple gelatinolytic activities.
These activities were changeable depending on the matrices surrounding the cells. Some cells revealed an MMP-2 activity of Mr of 92KDa. Interleukin 1 (IL-1) stimulated well the cells to generate MMPs which might degradate the basement membrane.
Osteoclast-like giant cells were certified histochemically to produce IL-1. Osteoclast may play a role to stimulate tumor cells to generate MMPs. On the other hand, tumor cells had a capacity to fuse peripheral monocyte to be osteoclast-like giant cells. Through those interactions, bone destruction may be advance.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] 南谷 和仁: "ヒト転移性腎癌の培養細胞樹立株において" 整形外科と災害外科. 39. 1699-1702 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 南谷 和仁: "横紋筋肉腫の培養細胞樹立株とそのゼラチナーゼ活性について" 中部日本整形外科災害外科学会雑誌. 34. 565-567 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 南谷 和仁: "骨肉腫細胞のコラゲナーゼ産生能について" 整形外科と災害外科. 39. 590-593 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 南谷 和仁: "培養骨肉腫細胞のmatrix metalloproteinase(MMP)活性と培養条件によるその変動について" 整形外科と災害外科. 41. 519-522 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Setsuro KOMIYA: "The pathogenesis and etiology of giant cell tumor of bone from a viewpoint of bone resorptive factors" Nippon Seikeigeka Gakkai Zasshi. 66. 485-492 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Setsuro KOMIYA,Kazuhito MINAMITANI: "Simple bone cyst Treatment by trepanation and studies on bone resorptive factor in cyst fluid with a theory of it′s pathogenesis" Clin.Orthop. 287. 204-211 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Setsuro KOMIYA,Kazuhito MINAMITANI: "Cementation in the treatment of giant cell tumor of bone" Arch Orthop Trauma Surg.112. 51-55 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Setsuro KOMIYA: "Aggressive bone tumorous lesion in infancy -Osteofibrous dysplasia of the tibia and fibula" J.Ped Orthop.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Setsuro Komiya: "The pathogenesis and etiology of giant cell tumor of bone from a viewpoint of bone resorptive factors" Nippon Seikeigeka Gakkai Zasshi. 66. 485-492 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Setsuro Komiya, Kazuhito Minamitani: "Simple bone cyst Treatment by trepanation and studies on bone resorptive factor in cyst fluid with a theory of it's pathogenesis" Clin.Orthop. 287. 204-211 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kazuhito Minamitani Setsuro Komiya et al: "Secretion of matrix metalloproteinases by cells cultured from human osteosarcoma"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kazuhito Minamitani, Setsuro Komiya et al: "Effect of Culture Condition on Secretion of Matrix Metalloproteinases from Cultured Osteosarcoma Cells"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Setsuro Komiya, Kazuhito Minamitani: "Osteoclast-like Multinucleated giant cells derived from peripherl monocytes by fusion"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Setsuro Komiya, Kazuhito Minamitani: "Cementation in the treatment of giant cell tumor of bone" Arch Orthop Trauma Surg. 112. 51-55 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Setsuro Komiya: "Aggressive bone tumorous lesion in infancy -Osteofibrous dysplasia" J.Ped Orthop.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Setauro Komiya: "Establishment of osteosarucoma cell line with features of pre-and osteobrasts"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 小宮 節郎: "軟骨肉腫の骨破壊能について" 中部日本整形外科災害外科学会雑誌. 33. 2420-2422 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小宮 節郎: "骨巨細胞腫(GCT)のインターロイキン-1産生能について" 中部日本整形外科災害外科学会雑誌. 33. 913-915 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 南谷 和仁: "骨吸収モデルとしての骨巨細胞腫単核細胞のPGE2の産生能について" 整形外科と災害外科. 38. 1152-1154 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 南谷 和仁: "骨肉腫細胞のコラゲナーゼ産生能について" 整形外科と災害外科. 39. 590-593 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 南谷 和仁: "ヒト転移性腎癌の培養細胞樹立株において" 整形外科と災害外科. 39. 1699-1702 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 南谷 和仁: "横紋筋肉腫の培養細胞樹立株とそのゲラチナーゼ活性について" 中部日本整形外科災害外科学会雑誌. 34. 565-567 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 南谷 和仁: "培養骨肉腫細胞のmatrix metalloproteinase(MMP)活性と培養条件によるその変動について" 整形外科と災害外科. 41. 519-522 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Setsuro Komiya: "The pathogenesis and etiology of giant cell tumor of bone from a viewpoint of bone resorptive factors" Nippon Seikeigeka Gakkai Zasshi. 66. 485-492 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Setsuro Komiya Kazuhito Minamitani: "Simple bone cyst Treatment by trepanation and studies on bone resorptive factor in cyst fluid with a theory of it's pathogenesis" Clin.Orthop.287. 204-211 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Setsuro Komiya Kazuhito Minamitani: "Cementation in the treatment of giant cell tumor of bone" Arch Orthop Trauma Surg.(1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Setsuro Komiya: "Aggressive bone tumorous lesion in infancy -Osteofibrous dysplasia of the tiba and fibula." J.Ped Orthop.

    • Related Report
      1992 Annual Research Report
  • [Publications] Setsuro Komiya: "Characterization of Cells Cultured From Human GiantーCell tumors of Bone.Phenotyprt Relationship to the MonoryteーMaiwphaye and Osteoclost" Clin.Orthop.258. 304-309 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小宮 節郎: "軟骨肉腫の骨破壊能について" 中部日本整形外科災害外科学会雑誌. 33. 301-304 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小宮 節郎: "骨巨細胞腫のインタ-ロイキン1産生能について" 中部日本整形災害外科学会雑誌. 33. 913-915 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 南谷 和仁: "骨吸収モデルとしての骨巨細胞腫単核細胞のPGE_2産生能について" 整形外科と災害外科. 38. 1152-1154 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 小宮 節郎: "RDCの骨破壊機序について" 日関外誌. 9. 245-250 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] "骨嚢腫におけるtrepanationの意義" 整形外科と災害外科. 38. 1570-1573 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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