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THE EFFECTS OF STELLATE GANGLION BLOCK TOGETHER WITH OXYGEN.CARBON DIOXIDE OR PROSTAGLANDIN E1 ON CRANIAL CIRCULATION

Research Project

Project/Area Number 02670674
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

KANEKO Tadanobu  Tohoku University, 医学部付属病院, 講師 (10091670)

Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1992: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1991: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1990: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsStellate ganglion block / Cerebral blood flow / Laser doppler flow meter / Oxygen / Carbon dioxide / Hypercapnia / Prostaglandin E1 / Vertebral blood flow / 脳血流 / プロマタグランジンE_1 / 総頚動脈血流量 / レーザードッブラー血流計 / プロスタグランジンE_1 / 炭酸ガス / 酸素 / 脳循環障害
Research Abstract

I studied the effects of left stellate ganglion block (LtSGB) used together with 5% CO2 inhalation or intravenous prostaglandin E1 (PGE1) for cerebral blood flow (CBF) in dogs. CBF was measured at the surface of cerebral cortex using disc-type-probe of laser doppler flow meter. LtSGB didn't change blood pressure, heart rate and cardiac output.LtSGB significantly increased left common carotid blood flow (Ca-BF) and left vertebral blood flow (VBF), but decreased CBF in SGB side. Inhalation of 5% CO2 induced hypercapnia (PaCO2:50mmHg) and increased CBF. These findings suggest that SGB increase external carotid blood flow in SGB side, but not internal carotid blood flow, therefore CO2 inhalation is effective for disturbance of CBF rather than SGB.The dose of 200ng/kg/min of PGE1 increased Ca-BF and VBF as much as approximately 10% by its direct vasodilative action, but didn't change CBF. After SGB, the effect of PGE1 was augumented clearly at the rate of increase of Ca-BF and VBF in SGB side.These findings suggest PGE1 has vasodilative effects for external carotid artery and vertebral artery as well as SGB,and remarkable synergic effects related to the sympathetic ganglion block. So, SGB using together with PGE1 is more effective for blood insufficiency of the region of external carotid artery and vertebral artery.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 徳富 昭一郎: "プロスグランジンE_1投下の臓器機能に及ぼす影響" 現代医療. 23. 2815-2819 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 徳富 昭一郎: "実験的星状神経節ブロック時の頭頸部血流量に及ぼす動脈血酸素分圧と炭素ガス分圧の影響" 麻酔.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SHOICHIRO TOKUTOMI et al: "The effects of prostaglandin E1 on the function of liver and kidney." Gendai Iryo. 23. 2815-2819

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 徳富 昭一郎: "プロスタグランジンE_1投与の臓器機能に及ぼす影響" 現代医療. 23. 2815-2819 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 徳富 昭一郎: "実験的星状神経節ブロックと酸素吸入などの頭部血流に及ぼす影響" 麻酔. 40. 844- (1991)

    • Related Report
      1992 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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