| Project/Area Number |
02670686
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | Kyushu University |
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Principal Investigator |
INADA Shoichi Kyushu University, Faculty of Medicine, Lecturer, 医学部, 講師 (90091305)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGUCHI Yoshiro Kyushu University, Faculty of Medicine Research Associate, 医学部, 助手 (20225791)
IRITA Kazuo Kyushu University, Faculty of Medicine Associate Professor, 医学部, 助教授 (80168541)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1990: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Halothane / immune-reaction / liver microsome / tri-fluolo acetate / drug induced liver damage / 免疫反応 / エンフルレン |
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| Research Abstract |
This project was planned to observe the appearance of anti-TFA antibody after halothane anesthesia in patients without liver damage. We have succeeded to gather 86 sera of halothane anesthetized patients which has been collected for the follow-up of post transfusion hepatitis at Transfusion Service of Kyushu University Hospital. None of these sera were reacted against halothane administered rat liver microsome by Western-blot technique. It is necessary for our study to confirm by rabbit immunized anti-TFA antibody which was made by National Institute of Health group in U. S. A. Unfortunately, we could not get this serum by immigration problem. We should make the antibody by ourselves for confirmation. Therefore, it is difficult to finish our project until the end of this series.
Then we planned another project which is to clarify the difference of hepato-toxicity of inhalation anestheties. We have analyzed the data which were accumulated in our Information Service for ten years. We have succeeded to choose 928 halothane anesthetized and 1766 enflurane anesthetized patients without liver dysfunction before anesthesia. Our result showed the incidence of post anesthetic mild liver damage in halothane group is twice higher than in enflurane group. The reason of this difference suggested the high metabolic rate of halothane in vivo.
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