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尿路悪性腫瘍の浸潤、転移において細胞外基質の果たす役割について

Research Project

Project/Area Number 02670720
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionJuntendo University School of Medicine

Principal Investigator

KITAGAWA Ryuichi  Juntendo University School of Med. Prof, 医学部, 教授 (20010035)

Co-Investigator(Kenkyū-buntansha) HONDA Shinichi  Juntendo University School of Med., 医学部, 助手
ISOBE Hideyuki  Juntendo University School of Med., 医学部, 助手 (20193401)
IWATA Shinji  Juntendo University School of Med., 医学部, 講師 (70168574)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
KeywordsLaminin / Type-IV collagen / Urological cancer / Metastasis / Basement membrane / IV型コラ-ゲン
Research Abstract

In recent years, it has become clear that various extracellular substrates play an important role in the process of invasion and metastasis of malignant tumors. In a previous study, we reported that the serum concentration of laminin in renal cell carcinoma and prostate cancer is elevated, and furthermore, is remarkably high in patients with metastasis. However, in bladder cancer, this level is elevated only in those with metastasis, indicating that the serum concentration of laminin is useful as a marker of metastasis or of clinical progression in the malignant tumor.
In the present study, we measured the serum concentration of type IV collagen 7S-domain, which constructs the basement membrane as well as laminin, and compared the result with the serum concentration of laminin, to evaluate the clinical significance of the findings.
The serum concentration of type IV collagen 7S-domain was not elevated significantly in any tumor type, although the serum concentration of laminin was elevated in patients with renal cell carcinoma, prostate cancer and bladder cancer with metastasis. There were no significant differences in the serum concentration of type IV collagen 7S-domain in any group with metastasis.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 岩田 真二,磯部 英行,藤田 真 北川 龍一 堀越 哲,船曵 和彦,小出 輝: "尿路移行上皮癌患者における血清ラミニン値の臨床的検討" 日本泌尿器科学会雑誌. 81. 518-523 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岩田 真二: "腎細胞癌のラミニン分泌能とその臨床的意義について" 順天堂医学. 36. 531-539 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 磯部 英行,岩田 真二 藤田 真,北川 龍一: "尿路悪性腫瘍患者における血清ラミニン濃度の臨床的検討" 泌尿器外科. 5. 141-145 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 磯部 英行,岩田 真二 藤目 真,北川 龍一: "泌尿器科的悪性腫瘍患者における血清IV型コラーゲン濃度の臨床的検討" 日本泌尿器科学会雑誌. 84. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岩田 真二,磯部 英行,藤目 真,北川 龍一,堀越 哲,船曳 和彦,小出 輝: "尿路移行上皮癌患者における血清ラミニン値の臨床的検討" 日本泌尿器科学会雑誌. 81. 518-523 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岩田 真二: "腎細胞癌のラミニン分泌能とその臨床的意義について" 順天堂医学. 36. 531-539 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 磯部 英行,岩田 真二,藤目 真,北川 龍一: "尿路悪性腫瘍患者における血清ラミニン濃度の臨床的検討" 泌尿器外科. 5. 141-145 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 磯部 英行,岩田 真二 藤目 真,北川 龍一: "泌尿器科的悪性腫瘍患者における血清IV型コラーゲン濃度の臨床的検討" 日本泌尿器科学会雑誌. 84. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 磯部 英行,岩田 真二,藤田 真,北川 龍一: "尿路悪性腫瘍患者における血清ラミニン濃度の臨床的検討" 泌尿器外科. 5. 141-145 (1995)

    • Related Report
      1991 Annual Research Report
  • [Publications] 磯部 英行,岩田 真二,藤田 真,北川 龍一: "尿路悪性腫瘍患者における血清IV型コラ-ゲナ濃度の臨床的検討ー血清ラミニン濃度との比較を中心にー" 日本泌尿器科学会雑誌.

    • Related Report
      1991 Annual Research Report
  • [Publications] 岩田 真二,磯部 英行,藤目 真,北川 龍一,堀越 哲,船曳 和彦,小出 輝: "尿路移行上皮癌患者における血清ラミニン値の臨床的検討" 日本泌尿器科学会雑誌. 81. 518-523 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 岩田 真二: "腎細胞癌のラミニン分泌能とその臨床的意義について" 順天堂医学. 36. 531-539 (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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