| Project/Area Number |
02670723
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KOTERA Shigeyuki Jikei University School of Medicine, Urology, Lecturer, 医学部, 講師 (30119797)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJO Hiroshi Jikei University School of Medicine, Urology, Staff, 医学部, 助手 (70217735)
NISHIDA Atsushi Jikei University School of Medicine, Urology, Staff, 医学部, 助手 (60218162)
IKEMOTO Isao Jikei University School of Medicine, Urology, Lecturer, 医学部, 講師 (40159645)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Serum LDH-X Activity / Experimentally Testicular Damage / Dibutil Phthalate / Experimentally Cryptorchidism / Cadmium Chloride / Testicular Torsion / 精巣障害 / 造精能 / 乳酸脱水素酸素 |
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| Research Abstract |
The usefulness of determining the release of LDH-X into the blood as a noninvasive indicator of various types of testicular damage was examined experimentally. Four kinds of acute (cadmium chloride administration and experimentally induced-testicular torsion) and subacute (dibutyl phthalate administration and experimentally induced-cryptorchidism) testicular damage were induced in mature male Wistar rats. LDH-X activity in the serum was assayed enzymatically at various times after the treatment. In all cases, serum LDH-X activity was detected after damage to theseminiferous tubules was proved histologically. The changes in the serum LDH-X activity were correlated with the histological changes. Therefore, we concluded that screening for LDH-X activity in serum might serve as a reliable and noninvasive marker for early detection of not only experimental testicular damage but also various clinical testicular disorders.
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