Pathophysiological Research of Cochlear efferent System
| Project/Area Number |
02670756
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tohoku University |
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Principal Investigator |
OHYAMA Kenji Tohoku university School of Medicine, Assistant Professor, 医学部附属病院・耳鼻咽喉科, 講師 (10152266)
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| Co-Investigator(Kenkyū-buntansha) |
HOZAWA Koji Tohoku University School of Medicine, Professor, 医学部・耳鼻咽喉科, 助手 (20199459)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Efferent innervation / Cochlear physiology / Otoacoustic emissions / Sensorineural hearing Loss / Distortion-product emissions / 歪成分耳音響放射 / 蝸牛 |
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| Research Abstract |
1)Investigation of cochlear physiology under derangement of efferent control system was conducted using otoacoustic emissions(OAEs)as an objective measure of the cochlear function. As the first step, an acoustic measuring system for known 4 classes of OAEs was constructed. In this series of research, many spontaneous OAE signals from guinea pigs, that had been regarded as extremely rare phenomenon, were closely examined. Basic features of guinea pig SOAEs were described and published. Efferent system did not look to affect on the SOAE in this animal.
2)As an application of the acoustic measuring system which was established in the starting ear of the project, the distortion-product(DP)OAE was measured in normal and hearing-impaired ears. The DP audiogram was proved to be an excellent indicator of cochlear functional integrity. It provides frequency
specific information of the cochlear physiology. However, the DP audiometry was not powerful enough to specify particular origin of a cochlear pathology. Further investigation seemed to be necessary before we can extract such an information from the DP audiometry.
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Report
(3 results)
Research Products
(14 results)
