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RELATIONSHIP BETWEEN GLYCOSAMINOGLYCANS IN THE TRABECULAR TISSUE AND THE INTRAOCULAR PRESSURE IN GLAUCOMAS

Research Project

Project/Area Number 02670790
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

TAWARA Akihiko  KYUSHU UNIV.,FAC.OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 (90117169)

Co-Investigator(Kenkyū-buntansha) 荒木 英生  九州大学, 医学部, 助手 (50193074)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
KeywordsAnterior chamber angle / Trabecular meshwork / Proteoglycans / Glycosaminoglycans / Cupromeronic Blue / Exfoliation syndrome / Corticosteroid-induced glaucoma / Goniodysgenetic glaucoma / スタージ・ウエーバー症候群 / クプロリニック・ブル- / 血液透析 / 先天緑内障
Research Abstract

1) The anterior chamber angle tissues obtained by trabeculectomy from the patients with goniodysgenetic glaucoma of early and late-onset were examined histologically and histochemically using Cupromeronic Blue. The results indicate that extensively accumulated basal lamina-like material in the thick juxtacanalicular connective tissue-like tissue of goniodysgenetic glaucoma contained a great deal of heparan sulfate-type proteoglycans. The results indicate that a large accumulation of basal lamina-like material with abundant proteoglycans may be responsible for the elevation of intraocular pressure in goniodysgenetic glaucoma.
2) The anterior chamber angle tissues obtained by trabeculectomy from a patient with corticosteroid-induced glaucoma were examined histologically and histochemically. In the juxtacanalicular connective tissue and in the intertrabecular spaces of the outer corneoscleral trabecular meshwork, there were accumulations of fine fibrillar and basal lamina-like extracellular matrix with a great deal of heparan sulfate-type proteoglycans. The accumulations of basal lamella-like material with proteoglycans are thought to have close relationship to glaucoma manifestation in corticosteroid-induced glaucoma.
3) The trabecular tissues from an ecucleated eye associated with exfoliation syndrome and from the patients with exfoliation glaucoma were examined histologically and histochemically. The exfoliative materials were observed in the trabecular meshwork, iris, ciliary body and lens, but not in the choroid or retina. Cupromeronic Blue staining revealed that the exfoliative materials contained many proteoglycans in them, which might have an association with the high intraocular pressure in this type of glaucoma.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 田原 昭彦: "正常ヒト眼前房隅角組織におけるプロテオグリカンの局在" あたらしい眼科. 7. 886-892 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 田原 昭彦: "隅角のプロテオグリカンと眼圧" あたらしい眼科. 7. 1579-1586 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 田原 昭彦、猪俣 孟: "眼の組織・病理アトラス57前房隅角組織のプロテオグリカン" 臨眼. 45. 1080-1081 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 田原 昭彦: "隅角発育異常緑内障" 福岡県眼科医会報. 138. 3-11 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 田原 昭彦、猪俣 孟: "隅角発育異常緑内障眼の前房隅角組織におけるプロテオグリカンの分布" あたらしい眼科(Suppl.1). 9. 47-53 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Taiji Sakamoto,Akihiko Tawara,Hajime Inomata: "Goniodysgenesis of the eye with arthrogryposis multiplex congenita" Ophthalmologica. 204. 210-214 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 田原 昭彦、猪俣 孟: "株式会社ミクス" 隅角発育異常緑内障(先天緑内障):東郁郎編 緑内障の薬物療法(Drug Therapyプラクティカルシリーズ), 207 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Akihiko Tawara: "Localization of proteoglycans in the trabecular tissue of the human eye" Journal of the Eye. 7-6. 886-892 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Akihiko Tawara: "Proteoglycans in the trabecular tissue and the intraocular pressure" Journal of the Eye. 7-11. 1579-1586 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Akihiko Tawara,Hajime Inomata: "Proteoglycans in the trabecular tissue" Jpn J Clinic Ophthalmol. 45-5. 598-599 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Akihiko Tawara: "Goniodysgenetic glaucoma" J Fukuoka Ophthlmol Soc. 138. 3-11 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Akihiko Tawara,Hajime Inomata: "Distribution of proteoglycans in the trabecular tissue of goniodysgenetic glaucoma" Journal of the Eye(Suppl 1). 9-13. 47-53 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Taiji Sakamoto,Akihiko Tawara,Hajime Inomata: "Goniodysgenesis of the eye with arthrogryposis multiplex congenita" Ophthalmologica. 204. 210-214 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Akihiko Tawara,Hajime Inomata: "Goniodysgenetic Glaucoma (Congenital Glaucoma)" Drug Therapy for Glaucoma. 46-52 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 田原 昭彦、猪俣 孟: "隅角発育異常緑内障眼の前房隅角組織におけるプロテオグリカンの分布" あたらしい眼科. 9. 47-53 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田原 昭彦,猪俣 孟: "眼の組織・病理アトラス 67 眼鉄錆症" 臨床眼科. 46. 598-599 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Taiji Sakamoto,Akihiko Tawara,Hajime Inomata: "Goniodysgenesis of the eye with arthrogryposis multiplex congenita" Ophthalmologica. 204. 210-214 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田原 昭彦: "巻頭言:強膜の細胞外マトリックス" 日眼. 97. 143-144 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 園田 康平、木村 一賢、桝本 美樹、坂本 泰二、田原 昭彦、猪俣 孟: "トリアムシノロンアセトニドの前部テノン嚢下注射後に眼圧が上昇した3例" 臨眼. 47. 167-171 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田原 昭彦: "中山書店、東京" Current Encyclopedia of Ophthalmology 9 眼科手術、5.緑内障 5.1外科的解剖,生理, 676 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田原 昭彦: "特集 眼科・耳鼻科からみた老年病 老年者の緑内障ー原発閉塞隅角緑内障ー" 老化と疾患. 4. 1572-1578 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 鎌田 京美: "血管新生緑内障患者における血液透析中の眼圧と血漿浸透圧の経時的変化" 臨床眼科. 45. 1715-1717 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 田原 昭彦: "隅角発育異常緑内障" 福岡県眼科医会報. 138. 3-11 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 田原 昭彦: "不均衡症候群による一過性眼圧上昇" 眼科診療QUESTIONS & ANSWERS. 880-881 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 田原 昭彦: "隅角発育異常緑内障眼の前房隅角組織におけるプロテオグリカンの分布" あたらしい眼科. 9. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 藤沢 公彦: "RubinsteinーTaybi症候群が疑われた小人症の隅角発育異常緑内障" 日本眼科会雑誌. 94. 693-700 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 田原 昭彦: "隅角のプロテオグリカンと眼圧" あたらしい眼科. 7. 1579-1586 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 田原 昭彦: "眼の組織・眼病理アトラス50 隈角発育異常緑内障晩発型" 臨床眼科. 44. 1922-1923 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 田原 昭彦: "Drug Therapyプラクティカルシリ-ズ 緑内障の薬物療法" 株式会社ミクス, 7 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 田原 昭彦: "眼科診療 Questions & Answers" 六法出版, 2 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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