| Project/Area Number |
02670808
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokushima University |
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Principal Investigator |
TAKAGI Tomomichi Tokushima Univ., Dent. Sch., Professor, 歯学部, 教授 (40048278)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Yoshiyuki Tokushima Univ., Fac., Farm. Sci., Res. Assoc., 薬学部, 助手 (20035554)
OKAMOTO Yasuo Tokushima Univ., Sch., Dent Hospit., Res. Assoc., 歯科部附属病院, 助手 (50213989)
YAMASHITA Kikuji Tokushima Univ., Sch., Dent., Res. Assoc., 歯学部, 助手 (30182497)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1990: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Bone morphogenetic protein / Induction / Heterotopic bone formation / Acellular mineral deposition / トランスフォ-メ-ション / ラット / 石灰化機構 |
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| Research Abstract |
For six years, we have extracted and purified the BMF(bone morphogenetic factor)from bovine bone, and also we have observed on the histological changes in the bone induction by BMF. We ascertained both in vivo and in vitro that satellite cells from the BMF implanted muscle tissues played a role of osteogenic cells under the effect of BMF. Recently, we purified a water soluble bone inductive protein and are checking the bone inductive activity. Acellular mineral deposition occurred in the implants of the BMF was cleared in our studies which were observed about the first changes just before the heterotopic bone induction. Perhaps the acellular mineral deposition is important for the beginning of new bone formation. Details on this acellular mineral deposition will be shown before long. We are trying now to find out an induction mechanism for the mesodermal derived tissues.
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