• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Interrelationship between epithelial and connective tissue attachments during wound healing of the periodontal tissues.

Research Project

Project/Area Number 02670815
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionTokyo Dental College

Principal Investigator

SHIMONO Masaki  Tokyo Dental College, Dept. Pathology, Professor, 歯学部, 教授 (00085771)

Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsPeriodontal tissues / Wound healing / Epithelial attachment / Connective tissue attachment / Long junctional epithelium / Replacement / Fibronectin / Laminin
Research Abstract

The purpose of this study was to investigate the interrelationship between epithelial and connective tissue attachments during wound healing of the periodontal tissues. Elastic rubber was inserted between the first and second molars of the maxilla in rats. The rubber was removed after one week, and a notch was made on the most apical region of the exposed root surface using a scalpel. The animals were fed a powdered fed, and sacrificed from immediately to 24 weeks after the removal of the elastic rubber. Regenerative changes of the periodontal tissues were observed light microscopically, immunohistochemically and electron microscopically. One week after the removal, the majority of the exposed root surface was covered by exudate and inflammatory cells although regenerative epithelial cells revealed to form a pocket epithelium. The notch was filled by epithelial cells of the pocket epitheium and the root surface was covered by a long junctional epithelium at the more apical site after four weeks. The long junctional epithelium tended to decrease in length and width with the passage of time. Twenty weeks after the removal, the notched root surface was covered by connective tissue which was closely similar in arrangement and morphology to the periodontal ligament. Immunohistochemical studies showed that laminin was positive to the basal lamina of the epithelial attachment and fibronectin was positive to that of the connective tissue attachment. From these results it is suggested that the epithelial attachment forming by a long junctional epithelium can be replaced by connective tissue attachment on the exposed root surface in rats.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] SHIMONO Masaki: "Vacuoles and vesicles in the rat junctional epithelium.A study using serial ultrathin sections." J.Periodontal Res.26. 85-90 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] ABIKO Yoshihiro: "An ultrastructural study of the pocket epithelium in rats." Bull.Tokyo Dent.Coll.32. 27-34 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] SHIMONO Masaki: "Long junctional epithelium in rats.Ultrastructures and immunohistochemistry." J.Periodontal Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] SHIMONO Masaki: "Predictable Avances in Oral Health Research" Tokyo Dental College, 190 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] SHIMONO Masaki: "Vacuoles and vesicles in the rat junctional epithelium. A study using serial ultrathin sections." J. Periodont. Res.26. 85-90 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] ABIKO Yoshihiro: "An ultrastructural study of the pocket epithelium in rats." Bull. Tokyo Dent. Coll.32. 27-34 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] SHIMONO Masaki: "Long junctional epithe lium in rats. Ultrastructures and immunohistochemistry" J. Periodont. Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] SHIMONO Masaki: Tokyo Dental College. Predictable Advances in Oral Health Research, 190 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] SHIMONO Masaki: "Vacuoles and vesicles in the rat junctional epithelium.A study using serial ultrathin sections." J.Periodontal Res.26. 85-90 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] ABIKO Yoshihiro: "Un ultrastructural study of the pocket epithelium in rats." Bull.Tokyo Dent.Coll. 32. 27-34 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] SHIMONO Masaki: "Long Junctionl epithelium in rats.Ultrastructures and immunohistochemistry." J.Periodontal Res.

    • Related Report
      1991 Annual Research Report
  • [Publications] SHIMONO Masaki: "Predictable Advances in Oral Health Research" Tokyo Dental College, 190 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] SHIMONO Masaki: "Vacuoles and vesicles in the rat junctional epithelium.A study using serial ultrathin sections." J.Periodont.Res.26. 85-90 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] ABIKO Yoshihiro: "An ultrastructural study of pocket epithelium in rats." Bull.Tokyo Dent.Coll.

    • Related Report
      1990 Annual Research Report

URL: 

Published: 1990-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi