| Project/Area Number |
02670838
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
HAMBA Michiko Showa Univ. Dept of Physiology, Associated Professor, 歯学部, 講師 (40119251)
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| Co-Investigator(Kenkyū-buntansha) |
HISAMITSU Hisashi Showa Univ. Sch. of Dent., Operative Dentistry Professor, 歯学部, 教授 (30092430)
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| Project Period (FY) |
1990 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Tooth-Pain / Feedin Center / Lateral Hypothlamus / Nociceptive Profection / Trigeminal Afferents / lateral hypothalamus / tooth pulp / projection / pain / Periaquaeductal gray / feeding center / trigeminal afferents |
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| Research Abstract |
The response of the rat lateral hypothalamic(LEA)neurons to tooth pulp electrical stimlation and the sensory projection pathway from the inusor pulp to the LHA were studied by electrophysiology and histology. 1)IIiA neurons that responded to contralateral lower incisor pulp stimulation were found in the lateral part of the LHA, These neurons also responded to intensive tail pinch, but not to innocuous stimuli nort appliedglucose. 2)Histological study after infection of WGA-HRP into the lateral part of the LHA revealed many retrogradely labeled neurons in the ventral part of the periventricular gray(FVG)in the mesencephalon. 3)The FVG neurons responded antidromically to LHA stimulation and-tb contralateral lower incisor pulp stimulation. 4)After injection of WGA-HRP into the ventral portion of the FVG many labeled cells were found in the contralateral subnucleus caudalis in the spinal tract of the trigeminal nucleus(NTST)where termination of the pulpal afferent was previously reported. It is thus suggested that the FVG is the most likely site of transmission relay of nociceptive inputs from incisors to the LHA.
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