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Dynamic mechanical-properties in skinned masticatory muscles

Research Project

Project/Area Number 02670843
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionTsurumi University

Principal Investigator

SAEKI Yasutake  Tsurumi Univ. Sch. Dent. Med., Associate Professor, 歯学部, 助教授 (20046113)

Co-Investigator(Kenkyū-buntansha) SHIOZAWA Kouichi  Tsurumi Univ. Sch. Dent. Med., Instructor, 歯学部, 助手 (30097315)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1991: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1990: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsMasticatory muscle / Cross-bridge kinetics / ATPase activity / Shortening velocity / Isometric tension / クロスブリッジ動力学 / 等尺性収縮張力 / カルシュ-ム感受性
Research Abstract

To mtudy the mechanical and metabolic properties of jaw muscles, we analyzed the Ca^<2+> sensitivity of isometric tension development, the ATPase activity, the maximum shortening velocity, and the tension transients in response to small(1 % of muscle length)step length perturbations in glycerinated masticatory muscles (1) of monkey whose mandibular movement seems to be quite similar to that of human and (2) of bite-opened guinea pig whose mandibular movement was focibly limited. In monkey preparations (reasseter, temporalis, superior and inferior lateral pterygoid), the isometric tension increased in sigmoid fashion with an increase in Ca^<2+> concentration. The pea for half maximum tension was 5.88 in masseter, 5.84 in tempolaris, 5.6 in superior lateral pterygoid and 5.90 in inferior lateral pterygoid. The maximum tension was highest in masseter (about 15 g/mm^2) and lowest in superior lateral pterygoid (about 9 g/mm^2). The time constant of the tension transient, which reflects the rate of cross-bridge cycling, was in the-order of masseter<tempolaris = superior lateral pterygoid<inferior lateral pterygoid., In bite-opened guinea pig preparations (masseter and digastric muscles), the Ca^<2+> sensitivity for tension development was decreased with bite-opening. The maximum tension increased significantly only in the masseter of 1-week-bite-opened guinea'pig, and the maximum shortening velocity was increased only in the 1-week-bite-opened digastric muscle. ATPase activity was always increased with an increase in tension development. However, the tension cost (ATPase activity/tension) was decreased only in the masseter of 1-week- bite-opened guinea pig. These results suggest that after 1-week-biteopening, the masseter produces greater tehsion by consuming ATP more economically, while the digastric decreases Ca^<2+> sensitivity and increases the maximum shortening velocity without changing the tension cost.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 塩沢 光一: "下顎口唇の機械的刺激及び開口時にカエル舌骨下筋に誘発される反射性応答" 歯科基礎医学会雑誌. 32. 122 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Shiozawa: "Reflex responses in the infrahyoid muscles by mechanical stimulation of the tongue in the frog" Japanese Journal of oral Biology. 32. 555-562 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 山中 一成: "サル咀嚼筋の力学的および生化学的検討" 日本口腔科学会雑誌. 40. 1173 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] I.Matsubara: "Cross-bridge movement in fast and slow skeletal muscles of the chick" Journal of Physiology. 441. 113-120 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] C.H.Paik: "Increase in vertical dimension alters mechanical properties and TAPase activity in guienea pig masseter" American Journal of Orthodontics and Dentofacial Orthopedics. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Shiozawa: "Reflex responses in the omohyoid and the sternchyoid muscles by mechanical stimulation of the lower lip in the frog" Tsurumi Shigaku. (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] C. H. Paik: "Increase in vertical dimension alters mechanical properties and ATPase activity in guinea pig masseter." Am. J. Orthod.(1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Shiozawa: "Reflex responses in the omohyoid and the sternohyoid muscles by mechanical stimulation of the lower lip in the frog." Tsurumi Shigaku. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Shiozawa: "Reflex responses of frog infrahyoid muscles evoked by mechanical stimulation and jaw opening." Jpn. J. Oral Biol.32. 122 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Shiozawa: "Reflex responses in the infrahyoid muscles by mechanical stimulation of the tongue in the frog." Jpn. J. Oral Biol.32. 555-562 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Yamanaka: "Mechanical and biochemical studies in monkey masticatory muscles." Nihon Koukuu Kagakukai Zashi. 40. 1173 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] I. Matsubara: "Cross-bridge movement in fast and slow skeletal muscles of the chick." J. Physiol.441. 113-120 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 山中 一成: "サル咀嚼筋の力学的および生化学的検討" 日本口腔科学会雑誌. 40. 1173 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] I.Matsubara: "Crossーbridge movement in fast and slow skeletal muscles of the chick" Journal of Physiology. 441. 113-120 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] C.H.Paik: "Increase in vertical dimension alters mechanical properties and ATPase activity in guinea pig masseter" American Journal of Orthodontics and Dentofacial Orthopedics. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Shiozawa: "Reflex responses in the omobyoid and the stermohyoid muscles by mechanical stimulation of the lower lip in the frog" Tsurumi Shigaku. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kouichi Shiozawa: "Reflex responses in the infrahyoid muscle by mechanical stimulation of the tonge in the frog." Jpn.J.Oral.Biol.32. 555-562 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 柴山 秀雄: "ディジタル信号処理技術を用いた心筋の力学特性測定システム" 医用電子と生体工学. 28. 466 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ichiro Matsubara: "Crossーbridge movement in fast and slow skeletal muscles of the chick." J.Physiol.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Paik,C.H.: "Increase in vertical dimension alters mechanical properties and ATPase activity in gunia pig masseter." Submitted to Am.J.Orthod.

    • Related Report
      1990 Annual Research Report
  • [Publications] 山中 一成: "サル咀嚼筋の力学的および生化学的検討" 第45回日本口腔科学会総会. (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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