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Development of Polyll-lacticdeacid microcapsule containing tetracycline for periodontal therapy

Research Project

Project/Area Number 02670860
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionOhu University School of Dentistry

Principal Investigator

MINABE Masato  OHU UNIVERSITY Associate, 歯学部, 講師 (60148004)

Co-Investigator(Kenkyū-buntansha) IKADA Yoshito  京都大学, 生体医療工学研究センター, 教授 (00025909)
SAITO Kazuhiro  奥羽大学, 歯学部, 助手 (60225696)
Project Period (FY) 1990 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1990: ¥900,000 (Direct Cost: ¥900,000)
KeywordsPeriodontal therapy / Slow release derice / Minocycline / Lysozyme chloride / Atelocollagen pellet / Poly(L-lactic acid) microsphere / ポリ乳酸マイクロスフェアー / コラ-ゲンペレット / 塩化リゾチウム / 薬剤徐放性 / 歯周ギクット / 歯周治療 / ポリ乳酸マイクロスクエア- / テトラサイクリン / 局所投与 / 薬物配送療法
Research Abstract

In the present study, tetracycline(TC)-immobilized Poly(L-lactic acid) microspheres(TC-PLA-MS) were produced experimentally, and the slow release and clinical effects of TC administered in this form were examined both in vivo and in vitro. The results indicated that TC-PLA-MS was effective in maintaining TC concentration to some extent in periodontal pockets, but less effective for sustained release of the drug in the pocket. Basic and clinical studies were then performed to evaluate the combined administration of atelocollagen pellets containing immobilized minocycline(MINO) which was superior to TC in antimicrobial activity and stability(MINO-P) and lysozyme chloride-immobilized atelocollagen pellets(LYSO-P) produced experimentally to suppress inflammation, which was thought to be responsible for the diminished slow-release of drugs, in the pocket. The following results were obtained : (1)combined MINO-P and LYSO-P administration improved the concentration and sustained release of MINO in the pocket ; (2)LYSO-P was effective in improving inflammation in the pocket ; (3)MINO-P was effective in improving the bacterial condition in the pocket both qualitatively and quantitatively ; and (4)the effectiveness of combined administration of MINO-P and LYSO-P was confirmed in a comprehensive evaluation that included clinical, microbiological and biochemical examinations. It was also found that oral administration of MINO (200 mg/day for 2 weeks) and local application of MINO-P(twice at a one-week interval) were almost equally effective for clinical improvement. These results indicate the usefulness of periodontal therapy with combined use of MINO-P and LYSO-P.

Report

(4 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • 1990 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 竹内 佳世: "歯周治療用テトラサイクリン固定化ポリ乳酸マイクロスクェアーの有効性に関する臨床的検討" 日本歯周病学会誌. 33. 199-206 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 三辺 正人: "歯周炎治療を目的としたテトラサイクリン固定化ポリ乳酸マイクロスクェアーの開発" Drng Delivery System. 6. 201-205 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 三辺 正人: "歯周治療用ミノサイクリンおよび塩化リゾチーム含有コラーゲンペレットの薬剤徐放性" 歯科薬物療法誌. 11. 166-173 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 竹内 佳世: "Local Drug Delirery Systemの歯周治療への応用ーミノサイクリンおよび塩化リゾチーム含有コラーゲンペレットの局所投与に関する臨床的検討" 日本歯周病学会誌. 34. 741-758 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 三辺 正人: "ミノサイクリンの局所投与法と経口投与法を用いた歯周病治療の臨床的比較研究" 日本歯科保存学会誌. 36. 272-281 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Minabe M, Iida M, takeuchi K et.al.: "Development of poly(L-lactic acid) microspheres containing tetracycline for periodontal therapy" Drug Delivery System. 6. 201-205 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Minabe M, Kimura K, Takeuchi K et.al.: "Local drug delivery using collagen pellets containing minocycline and lysozyme chloride for periodontal therapy" Oral Therapeutics and Pharmacology. 11. 166-173 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 竹内 佳世: "歯周治療用テトラサイクリン固定化ポリ乳酸マイクロスフェアーの有効性に関する臨床的検討" 日本歯周病学会誌. 33. 199-206 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 三辺 正人: "歯周炎治療を目的としたテトラサイクリン固定化ポリ乳酸マイクロスフェアーの開発" Drug Delivery System. 6. 201-205 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 三近 正人: "歯周治療用ミノサイクリンおよび塩化リゾチーム含有コラーゲンペレットの薬剤徐放性" 歯科薬物療法誌. 11. 166-173 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 竹内 佳世: "Local Drug Delivery Systemの歯周治療への応用-ミノサイクリンおよび塩化リゾチーム含有コラーゲンペレットの局所投与に関する臨床的検討" 日本歯周病学会誌. 34. 741-758 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 三辺 正人: "ミノサイクリンの局所投与法と経口投与法を用いた歯周病治療の臨床的比較研究" 日本歯科保存学会誌. 36. 272-281 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 三辺 正人: "歯周治療を目的としたテトラサイクリン固定化 ポリ乳酸マイクロスクエア-の開発" Drug Delivery System. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 竹内 佳也: "歯周治療用テトラサイクリン固定化ポリ乳酸 マイクロスクエア-の有効性に関する臨床的検討" 日本歯周病学会誌. 1. (1991)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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