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Development of biocompatible metal-BMP composit

Research Project

Project/Area Number 02670882
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 補綴理工系歯学
Research InstitutionSchool of Dentistry Aichigakuin University

Principal Investigator

KAWAI Tatsushi  Dent. Mat. Sci. Aichigakuin Univ. Assistant Professor, 歯学部・歯科理工学, 講師 (60167351)

Co-Investigator(Kenkyū-buntansha) BAN Seiji  Dent. Mat. Sci. Aichigakuin Univ. Assistant Professor, 歯科理工学, 講師 (10159105)
Project Period (FY) 1990 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1990: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsImplant / OSTEOGENESITY / Bone morphogenetic protein / BMP / Biomaterial / Titanium / Composit material / Biocompatible metal
Research Abstract

In order to prepare water soluble BMP,S-200 gel filtration was performed, then higher molecular weight than 40,000 Da was cut off. The fraction of 10,000-30,000 Da was dialyzed against water and centrifuge out the ppt. The supernatant was lyophilized. This was water soluble BMP.This BMP and powdered pure metals(Ag,Al,Au,Co,Cr,Cu,Fe,Ge,In,Ir,Mn,Mo,Ni,Pb,Pd,Pt,Sb,Sn,Ta,Ti,W,Zn)were combined, then the effect of each metals on new bone formation was investigated. In the implantation of Au,Mo,Ti, there were no inhibition of new bone formation under the existence of these metals. On the contrary, Cu,Fe,Sb suppressed osteoinduction remarkably and new bone formation did not occur completely. With other metals, new bone formation were observed but the amounts of new bone were decreased. Uptake of [3H]-thyamidine, [35]-sulfate were measured to know the DNA synthesis, GAG (glycosaminoglycan) for the quantitative analysis of cytotoxity and chondrogenesis by Au,Pt,Ni,Ti.
Au,Pt.Ti did not suppress the DNA synthesis, and Ni did remarkably. Same phenomena was obtained in GAG synthesis. In some condition Pt inhibit osteoactivity slightyl, however in usual experimental condition, it did not effect on new bone formation. Consequently, Au-Pt alloy seems to be a excellent candidate for the developing biocompatible alloy. Addition of Mo to Au-Pt will be a good modification. Ti showed excellent property for a biocompatible metal mentioned as previously.

Report

(3 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] T.Kawai et al: "The Influence of pure metals on the osteoinductive activity" Connective tissue research. 27(2,3). 161-161 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] S.Kurita,T.Kawai et al.: "Influence of metallic ions on DNA synthesis and GAA synthesys in vivo." Connective tissue research. 27(2,3). 145-145 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] M.Umemura.T.Kawai et al: "Delivery System Bone morphogenetic Protein with Atelocollagen" Connective tissue research. 27(2,3). 161-161 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 河合 達志他: "各種金属の骨形成に与える影響について-BMP作用下における各種金属の影響." 硬組織研究技術学会誌. 1(1). 53-54 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 長谷川 二郎,河合 達志: "骨形成因子(BMP)の開発とその現況、" 歯科ジャーナル. 36(2). 275-283 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T.Kawai et al: "Osteoinductive activity of BMP combined pure titanium" Clin.Orthop.00-00 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tatsushi KAWAI: "Osteoinductive activity of BMP combined pure titanium." Clin Orthop. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tatsushi KAWAI: "The effect of metals of BMP activity" Hardtissue research and technology. 1(1). 53-54 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Jiro HASEGAWA: "Development of BMP and current studies" Shika Journal. 36(2). 275-283 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tatsushi KAWAI: "The influence of pure metals on the osteoinductive activity" Connective Tissue Research. 27(2-3). 161-161 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Jiro HASEGAWA: "Consideration of materials for substructure of dental implant from the view of dental materials" Oral & Maxillofacial implants. 3(6). 415-421 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T.Kawai: "The influence of pure metalas on the osteoinuctive activity" Connective tissue research. 27(2,3). 161-161 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Kurita,T.Kawai et al: "Influence of metallic ions on DNA synthesis and GAG synthesys in vitro" Connective tissue research. 27(2,3). 145-145 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Umemura,T.Kawai et al: "Delivery System Bone morphogenetic Protein with Atelocollagen" Connective tissue research. 27(2,3). 161-161 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Kawai: "Osteoinductive activity of BMP combined pure titanium" Clin.Orthop. 00-00 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kawai,T.: "Bone formation of BMP Bound Inplants." JDR. 69. 291-291 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ohno,Y.: "Bone Inductive Ability of TiーBMP Implant Complex." JDR. 69. 213-213 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 長谷川 二郎: "下部構造用材料を歯科材料の立場から考えるー現状とその将来への展望ー" オ-ラル・マキシロフェイシャル・インプラント. 3(6). 415-421 (1990)

    • Related Report
      1990 Annual Research Report

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Published: 1990-04-01   Modified: 2016-04-21  

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